KEGG   PATHWAY: mbb00630
Entry
mbb00630                    Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Mycobacterium tuberculosis variant bovis BCG Pasteur 1173P2
Class
Metabolism; Carbohydrate metabolism
Pathway map
mbb00630  Glyoxylate and dicarboxylate metabolism
mbb00630

Module
mbb_M00012  Glyoxylate cycle [PATH:mbb00630]
mbb_M00621  Glycine cleavage system [PATH:mbb00630]
mbb_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:mbb00630]
Other DBs
GO: 0046487 0043648
Organism
Mycobacterium tuberculosis variant bovis BCG Pasteur 1173P2 [GN:mbb]
Gene
BCG_1954  aceA; Probable isocitrate lyase aceA [KO:K01637] [EC:4.1.3.1 4.1.3.30]
BCG_0507  icl; Isocitrate lyase icl [KO:K01637] [EC:4.1.3.1 4.1.3.30]
BCG_3725  acs; acetyl-coenzyme A synthetase acs [KO:K01895] [EC:6.2.1.1]
BCG_1872c  glcB; Probable malate synthase G glcB [KO:K01638] [EC:2.3.3.9]
BCG_1300  mdh; Probable malate dehydrogenase mdh [KO:K00024] [EC:1.1.1.37]
BCG_0941c  citA; Probable citrate synthase II citA [KO:K01647] [EC:2.3.3.1]
BCG_0948  gltA2; probable citrate synthase i gltA2 [KO:K01647] [EC:2.3.3.1]
BCG_1192  gltA1; Probable citrate synthase I gltA1 [KO:K01659] [EC:2.3.3.5]
BCG_1537c  acn; Probable aconitate hydratase acn [KO:K27802] [EC:4.2.1.3 4.2.1.99]
BCG_3610  fadA5; Probable acetyl-CoA acetyltransferase fadA5 [KO:K00626] [EC:2.3.1.9]
BCG_3620c  fadA6; Probable acetyl-CoA acetyltransferase fadA6 [KO:K00626] [EC:2.3.1.9]
BCG_1903  Conserved hypothetical protein [KO:K00626] [EC:2.3.1.9]
BCG_1385  fadA4; Probable acetyl-CoA acetyltransferase fadA4 [KO:K00626] [EC:2.3.1.9]
BCG_0911  fadA; Possible acyl-CoA thiolase fadA [KO:K00626] [EC:2.3.1.9]
BCG_0966c  possible lipid carrier protein or keto acyl-CoA thiolase [KO:K00626] [EC:2.3.1.9]
BCG_3587  Probable lipid carrier protein or keto acyl-coa thiolase [KO:K00626] [EC:2.3.1.9]
BCG_0281  fadA2; Probable acetyl-CoA acyltransferase fadA2 [KO:K00626] [EC:2.3.1.9]
BCG_1132c  fadA3; Probable beta-ketoacyl CoA thiolase fadA3 [KO:K00626] [EC:2.3.1.9]
BCG_1384c  Conserved hypothetical protein [KO:K05606] [EC:5.1.99.1]
BCG_3314  accA3; Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase (alpha chain) accA3: biotin carboxylase + biotin carboxyl carrier protein [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.4.1.- 6.3.4.14]
BCG_3309  accD5; PRobable propionyl-CoA carboxylase beta chain 5 accD5 [KO:K27094] [EC:6.4.1.3 6.4.1.- 2.1.3.15]
BCG_3310  Conserved hypothetical protein [KO:K27095]
BCG_2264  accD6; Acetyl/propionyl-CoA carboxylase (beta subunit) accD6 [KO:K18472] [EC:6.4.1.2 6.4.1.3 2.1.3.15]
BCG_1556  mutB; Probable methylmalonyl-COA mutase large subunit mutB [KO:K01847] [EC:5.4.99.2]
BCG_1555  mutA; Probable methylmalonyl-CoA mutase small subunit mutA [KO:K01847] [EC:5.4.99.2]
BCG_2295  Probable dehydrogenase [KO:K00104] [EC:1.1.99.14]
BCG_2882c  glnA4; Probable glutamine synthetase glnA4 [KO:K01915] [EC:6.3.1.2]
BCG_2237  glnA1; Glutamine synthetase glnA1 [KO:K01915] [EC:6.3.1.2]
BCG_2239c  glnA2; Probable glutamine synthetase glnA2 [KO:K01915] [EC:6.3.1.2]
BCG_1915  glnA3; Probable glutamine synthetase glnA3 [KO:K01915] [EC:6.3.1.2]
BCG_0101c  glyA2; Probable serine hydroxymethyltransferase glyA2 [KO:K00600] [EC:2.1.2.1]
BCG_1153  glyA1; Probable Serine hydroxymethyltransferase 1 glyA1 [KO:K00600] [EC:2.1.2.1]
BCG_1867  gcvB; Probable glycine dehydrogenase gcvB [KO:K00281] [EC:1.4.4.2]
BCG_2227c  gcvT; Probable aminomethyltransferase GcvT (Glycine cleavage system T protein) [KO:K00605] [EC:2.1.2.10]
BCG_0502  lpd; Dihydrolipoamide dehydrogenase lpd [KO:K00382] [EC:1.8.1.4]
BCG_1861  gcvH; Probable glycine cleavage system H protein gcvH [KO:K02437]
BCG_2221c  Conserved hypothetical protein [KO:K00865] [EC:2.7.1.165]
BCG_1308c  kgd; alpha-ketoglutarate decarboxylase [KO:K01616] [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
BCG_2985  purU; Probable formyltetrahydrofolate deformylase purU [KO:K01433] [EC:3.5.1.10]
BCG_0152c  oxcA; Probable oxalyl-CoA decarboxylase oxcA [KO:K01577] [EC:4.1.1.8]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
mbb00010  Glycolysis / Gluconeogenesis
mbb00020  Citrate cycle (TCA cycle)
mbb00030  Pentose phosphate pathway
mbb00053  Ascorbate and aldarate metabolism
mbb00071  Fatty acid degradation
mbb00230  Purine metabolism
mbb00250  Alanine, aspartate and glutamate metabolism
mbb00260  Glycine, serine and threonine metabolism
mbb00620  Pyruvate metabolism
mbb00710  Carbon fixation by Calvin cycle
mbb00750  Vitamin B6 metabolism
mbb00910  Nitrogen metabolism
KO pathway
ko00630   
LinkDB

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