KEGG   PATHWAY: mcal00983
Entry
mcal00983                   Pathway                                
Name
Drug metabolism - other enzymes - Mus caroli (Ryukyu mouse)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
mcal00983  Drug metabolism - other enzymes
mcal00983

Organism
Mus caroli (Ryukyu mouse) [GN:mcal]
Gene
110286595  Hprt1; hypoxanthine-guanine phosphoribosyltransferase isoform X1 [KO:K00760] [EC:2.4.2.8]
110296235  Impdh1; inosine-5'-monophosphate dehydrogenase 1 isoform X2 [KO:K00088] [EC:1.1.1.205]
110301086  Impdh2; inosine-5'-monophosphate dehydrogenase 2 isoform X2 [KO:K00088] [EC:1.1.1.205]
110290590  Gmps; GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
110307964  Tpmt; thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
110312137  Xdh; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
110288733  Itpa; inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
110300388  carboxylesterase 1D [KO:K01044] [EC:3.1.1.1]
110299985  carboxylesterase 1E isoform X1 [KO:K01044] [EC:3.1.1.1]
110300015  carboxylesterase 1F [KO:K01044] [EC:3.1.1.1]
110300390  carboxylesterase 1C isoform X1 [KO:K01044] [EC:3.1.1.1]
110300016  carboxylesterase 1E-like isoform X1 [KO:K01044] [EC:3.1.1.1]
110300014  liver carboxylesterase 1 [KO:K01044] [EC:3.1.1.1]
110300389  liver carboxylesterase 1-like [KO:K01044] [EC:3.1.1.1]
110300880  carboxylesterase 1C-like [KO:K01044] [EC:3.1.1.1]
110299650  acylcarnitine hydrolase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
110299697  pyrethroid hydrolase Ces2e isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
110299698  acylcarnitine hydrolase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
110299706  acylcarnitine hydrolase-like isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
110299923  LOW QUALITY PROTEIN: acylcarnitine hydrolase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
110299978  acylcarnitine hydrolase-like isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
110300204  acylcarnitine hydrolase-like isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
110299699  cocaine esterase [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
110283898  UDP-glucuronosyltransferase 1-1 isoform X1 [KO:K00699] [EC:2.4.1.17]
110288078  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
110288413  UDP-glucuronosyltransferase 2B4-like [KO:K00699] [EC:2.4.1.17]
110294338  UDP-glucuronosyltransferase 2A2 isoform X1 [KO:K00699] [EC:2.4.1.17]
110288611  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
110293925  UDP-glucuronosyltransferase 2A3 [KO:K00699] [EC:2.4.1.17]
110293926  UDP-glucuronosyltransferase 2B17-like isoform X1 [KO:K00699] [EC:2.4.1.17]
110308636  UDP-glucuronosyltransferase 1-3-like [KO:K00699] [EC:2.4.1.17]
110295246  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
110295248  UDP-glucuronosyltransferase 2B17 [KO:K00699] [EC:2.4.1.17]
110295249  UDP-glucuronosyltransferase 2B17-like isoform X2 [KO:K00699] [EC:2.4.1.17]
110288988  UDP-glucuronosyltransferase 1-8-like [KO:K00699] [EC:2.4.1.17]
110288989  UDP-glucuronosyltransferase 1-7C [KO:K00699] [EC:2.4.1.17]
110288990  UDP-glucuronosyltransferase 1-9 [KO:K00699] [EC:2.4.1.17]
110288991  UDP-glucuronosyltransferase 1-9-like isoform X1 [KO:K00699] [EC:2.4.1.17]
110295266  Gusb; beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
110293297  Cda; cytidine deaminase [KO:K01489] [EC:3.5.4.5]
110310004  Tymp; thymidine phosphorylase [KO:K00758] [EC:2.4.2.4]
110291713  Dpyd; dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
110311118  Dpys; dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
110302927  Upb1; beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
110305638  Upp1; uridine phosphorylase 1 [KO:K00757] [EC:2.4.2.3]
110287076  Upp2; uridine phosphorylase 2 isoform X1 [KO:K00757] [EC:2.4.2.3]
110290554  Uckl1; uridine-cytidine kinase-like 1 isoform X2 [KO:K00876] [EC:2.7.1.48]
110310094  Uck1; uridine-cytidine kinase 1 [KO:K00876] [EC:2.7.1.48]
110294192  Uck2; uridine-cytidine kinase 2 isoform X1 [KO:K00876] [EC:2.7.1.48]
110304714  Tk1; thymidine kinase, cytosolic [KO:K00857] [EC:2.7.1.21]
110299795  Tk2; thymidine kinase 2, mitochondrial isoform X1 [KO:K00857] [EC:2.7.1.21]
110311787  Umps; uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
110292621  Cmpk1; UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
110297993  Rrm1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
110310656  Rrm2b; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
110306805  Rrm2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
110301716  Nme6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
110290609  Nme7; nucleoside diphosphate kinase 7 isoform X3 [KO:K00940] [EC:2.7.4.6]
110283895  Nme4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
110283835  Nme3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
110304443  nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
110304444  Nme1; nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
110308346  nucleoside diphosphate kinase B-like [KO:K00940] [EC:2.7.4.6]
110286763  Dut; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial [KO:K01520] [EC:3.6.1.23]
110305648  Mpo; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
110300118  arylamine N-acetyltransferase 2 [KO:K00622] [EC:2.3.1.5]
110300659  arylamine N-acetyltransferase 1 [KO:K00622] [EC:2.3.1.5]
110300688  arylamine N-acetyltransferase 3 [KO:K00622] [EC:2.3.1.5]
110297258  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
110296158  Mgst1; microsomal glutathione S-transferase 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
110285527  Gsto1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
110285529  glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
110290673  Gstm3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
110291409  glutathione S-transferase Mu 2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
110291410  glutathione S-transferase Mu 7 [KO:K00799] [EC:2.5.1.18]
110291412  glutathione S-transferase Mu 6 isoform X1 [KO:K00799] [EC:2.5.1.18]
110291414  LOW QUALITY PROTEIN: glutathione S-transferase Mu 3-like [KO:K00799] [EC:2.5.1.18]
110291415  glutathione S-transferase Mu 2 [KO:K00799] [EC:2.5.1.18]
110291416  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
110291417  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
110302042  glutathione S-transferase Mu 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
110284504  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
110302372  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
110291754  Mgst2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
110301652  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
110301653  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
110301654  glutathione S-transferase A1-like [KO:K00799] [EC:2.5.1.18]
110294358  Mgst3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
110303140  glutathione S-transferase theta-3 [KO:K00799] [EC:2.5.1.18]
110303152  glutathione S-transferase theta-2 [KO:K00799] [EC:2.5.1.18]
110303153  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
110303154  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
110288966  glutathione S-transferase A1 [KO:K00799] [EC:2.5.1.18]
110285868  glutathione S-transferase P 1 [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
LinkDB

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