KEGG   PATHWAY: mee00230
Entry
mee00230                    Pathway                                
Name
Purine metabolism - Methylobacterium currus
Class
Metabolism; Nucleotide metabolism
Pathway map
mee00230  Purine metabolism
mee00230

Module
mee_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:mee00230]
mee_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:mee00230]
mee_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:mee00230]
mee_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:mee00230]
mee_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:mee00230]
mee_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:mee00230]
Other DBs
GO: 0006163 0042278
Organism
Methylobacterium currus [GN:mee]
Gene
DA075_23175  phosphopentomutase [KO:K01839] [EC:5.4.2.7]
DA075_21335  alpha-D-glucose phosphate-specific phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
DA075_22460  ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
DA075_29470  amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
DA075_22475  phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
DA075_29675  phosphoribosylglycinamide formyltransferase [KO:K11175] [EC:2.1.2.2]
DA075_15605  phosphoribosylformylglycinamidine synthase subunit PurL [KO:K23269] [EC:6.3.5.3]
DA075_25810  phosphoribosylformylglycinamidine synthase subunit PurS [KO:K23264] [EC:6.3.5.3]
DA075_25805  phosphoribosylformylglycinamidine synthase subunit PurQ [KO:K23265] [EC:6.3.5.3 3.5.1.2]
DA075_29670  phosphoribosylformylglycinamidine cyclo-ligase [KO:K01933] [EC:6.3.3.1]
DA075_28615  5-(carboxyamino)imidazole ribonucleotide synthase [KO:K01589] [EC:6.3.4.18]
DA075_28610  purE; 5-(carboxyamino)imidazole ribonucleotide mutase [KO:K01588] [EC:5.4.99.18]
DA075_07660  phosphoribosylaminoimidazolesuccinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
DA075_03830  phosphoribosylaminoimidazolesuccinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
DA075_13610  adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
DA075_19640  purH; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase PurH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
DA075_25800  adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
DA075_19835  bifunctional metallophosphatase/5'-nucleotidase [KO:K11751] [EC:3.1.3.5 3.6.1.45]
DA075_09470  5'/3'-nucleotidase SurE [KO:K03787] [EC:3.1.3.5 3.1.3.6]
DA075_19725  purine-nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
DA075_08800  pgeF; peptidoglycan editing factor PgeF [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
DA075_12980  hpt; hypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
DA075_25740  IMP dehydrogenase [KO:K00088] [EC:1.1.1.205]
DA075_05435  nucleoside-diphosphate kinase [KO:K00940] [EC:2.7.4.6]
DA075_21140  rdgB; non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family [KO:K01519] [EC:3.6.1.66]
DA075_22735  xanthine phosphoribosyltransferase [KO:K00769] [EC:2.4.2.22]
DA075_03315  xanthine dehydrogenase family protein molybdopterin-binding subunit [KO:K11177] [EC:1.17.1.4]
DA075_01325  xanthine dehydrogenase family protein molybdopterin-binding subunit [KO:K11177] [EC:1.17.1.4]
DA075_29020  xanthine dehydrogenase family protein molybdopterin-binding subunit [KO:K11177] [EC:1.17.1.4]
DA075_03320  xanthine dehydrogenase family protein subunit M [KO:K11178] [EC:1.17.1.4]
DA075_01330  xanthine dehydrogenase family protein subunit M [KO:K11178] [EC:1.17.1.4]
DA075_29025  xanthine dehydrogenase family protein subunit M [KO:K11178] [EC:1.17.1.4]
DA075_03325  (2Fe-2S)-binding protein [KO:K13483]
DA075_01335  (2Fe-2S)-binding protein [KO:K13483]
DA075_29030  aldehyde dehydrogenase iron-sulfur subunit [KO:K13483]
DA075_26300  type 1 glutamine amidotransferase [KO:K01951] [EC:6.3.5.2]
DA075_18225  type 1 glutamine amidotransferase [KO:K01951] [EC:6.3.5.2]
DA075_31765  glutamine-hydrolyzing GMP synthase [KO:K01951] [EC:6.3.5.2]
DA075_15325  glutamine amidotransferase [KO:K01951] [EC:6.3.5.2]
DA075_20360  glutamine amidotransferase [KO:K01951] [EC:6.3.5.2]
DA075_19670  nucleoside deaminase [KO:K01487] [EC:3.5.4.3]
DA075_26145  guanylate kinase [KO:K00942] [EC:2.7.4.8]
DA075_19810  vitamin B12-dependent ribonucleotide reductase [KO:K00525] [EC:1.17.4.1]
DA075_23370  deoxyguanosinetriphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
DA075_26845  HD family hydrolase [KO:K06952] [EC:3.1.3.89]
DA075_15075  bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
DA075_29645  ppx; exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
DA075_00060  Ppx/GppA family phosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
DA075_12130  guanylate cyclase [KO:K01768] [EC:4.6.1.1]
DA075_29965  adenylate/guanylate cyclase domain-containing protein [KO:K01768] [EC:4.6.1.1]
DA075_08615  adenylate/guanylate cyclase domain-containing protein [KO:K01768] [EC:4.6.1.1]
DA075_04415  adenylate/guanylate cyclase domain-containing protein [KO:K01768] [EC:4.6.1.1]
DA075_22105  adenylate/guanylate cyclase domain-containing protein [KO:K01768] [EC:4.6.1.1]
DA075_31105  adenylate/guanylate cyclase domain-containing protein [KO:K01768] [EC:4.6.1.1]
DA075_28025  adenylate/guanylate cyclase domain-containing protein [KO:K01768] [EC:4.6.1.1]
DA075_19620  adenylate/guanylate cyclase domain-containing protein [KO:K01768] [EC:4.6.1.1]
DA075_07060  adenylate/guanylate cyclase domain-containing protein [KO:K01768] [EC:4.6.1.1]
DA075_14650  HAMP domain-containing protein [KO:K01768] [EC:4.6.1.1]
DA075_06370  adenylate/guanylate cyclase domain-containing protein [KO:K01768] [EC:4.6.1.1]
DA075_16425  CYTH domain-containing protein [KO:K01768] [EC:4.6.1.1]
DA075_21605  adenylate/guanylate cyclase domain-containing protein [KO:K01768] [EC:4.6.1.1]
DA075_13585  adenylosuccinate synthase [KO:K01939] [EC:6.3.4.4]
DA075_26350  AMP nucleosidase [KO:K01241] [EC:3.2.2.4]
DA075_23925  ade; adenine deaminase [KO:K01486] [EC:3.5.4.2]
DA075_31810  TIGR00282 family metallophosphoesterase [KO:K09769] [EC:3.1.4.16]
DA075_14030  adenylate kinase [KO:K00939] [EC:2.7.4.3]
DA075_07010  nucleoside triphosphate pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
DA075_07150  phosphodiesterase [KO:K03651] [EC:3.1.4.53]
DA075_19780  metallophosphoesterase [KO:K03651] [EC:3.1.4.53]
DA075_15940  cysC; adenylyl-sulfate kinase [KO:K00860] [EC:2.7.1.25]
DA075_27050  sulfate adenylyltransferase subunit CysN [KO:K00956] [EC:2.7.7.4]
DA075_27055  sulfate adenylyltransferase subunit CysD [KO:K00957] [EC:2.7.7.4]
DA075_04800  pucL; urate oxidase [KO:K00365] [EC:1.7.3.3]
DA075_00240  NAD(P)/FAD-dependent oxidoreductase [KO:K22879] [EC:1.14.13.113]
DA075_21885  NAD(P)/FAD-dependent oxidoreductase [KO:K22879] [EC:1.14.13.113]
DA075_03440  uraH; hydroxyisourate hydrolase [KO:K07127] [EC:3.5.2.17]
DA075_08235  5-hydroxyisourate hydrolase [KO:K07127] [EC:3.5.2.17]
DA075_23040  Asp/Glu racemase [KO:K16841] [EC:5.1.99.3]
DA075_12730  Asp/Glu/hydantoin racemase [KO:K16841] [EC:5.1.99.3]
DA075_31650  allantoinase PuuE [KO:K16842] [EC:3.5.2.5]
DA075_12395  allantoate amidohydrolase [KO:K02083] [EC:3.5.3.9]
DA075_16085  allantoate amidohydrolase [KO:K02083] [EC:3.5.3.9]
DA075_01140  ureidoglycolate hydrolase [KO:K01483] [EC:4.3.2.3]
DA075_29000  ureC; urease subunit alpha [KO:K01428] [EC:3.5.1.5]
DA075_28985  urease subunit gamma [KO:K14048] [EC:3.5.1.5]
DA075_03775  gamma-glutamyltransferase family protein [KO:K22602] [EC:3.5.1.126]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
mee00030  Pentose phosphate pathway
mee00220  Arginine biosynthesis
mee00250  Alanine, aspartate and glutamate metabolism
mee00260  Glycine, serine and threonine metabolism
mee00340  Histidine metabolism
mee00630  Glyoxylate and dicarboxylate metabolism
mee00730  Thiamine metabolism
mee00740  Riboflavin metabolism
mee00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

DBGET integrated database retrieval system