KEGG   PATHWAY: mmea04145
Entry
mmea04145                   Pathway                                
Name
Phagosome - Malurus melanocephalus (red-backed fairy wren)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
mmea04145  Phagosome
mmea04145

Other DBs
GO: 0045335
Organism
Malurus melanocephalus (red-backed fairy wren) [GN:mmea]
Gene
130579087  VAMP3; vesicle-associated membrane protein 3 [KO:K13505]
130581892  STX12; syntaxin-12 [KO:K13813]
130572593  STX7; syntaxin-7 isoform X1 [KO:K08488]
130575083  actin, cytoplasmic type 5 [KO:K05692]
130575713  ACTB; actin, cytoplasmic 1 [KO:K05692]
130583706  ACTG1; actin, cytoplasmic 2 [KO:K05692]
130577861  STX18; syntaxin-18 isoform X1 [KO:K08492]
130577445  SEC22B; vesicle-trafficking protein SEC22b [KO:K08517]
130587343  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
130587344  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
130587791  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
130587875  class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
130588048  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
130588108  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
130587010  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
130587298  H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752]
130587794  LOW QUALITY PROTEIN: SLA class II histocompatibility antigen, DQ haplotype C beta chain-like [KO:K06752]
130587795  HLA class II histocompatibility antigen, DR beta 3 chain-like [KO:K06752]
130588442  HLA class II histocompatibility antigen, DM beta chain-like [KO:K06752]
130588576  H-2 class II histocompatibility antigen, I-E beta chain-like [KO:K06752]
130588593  LOW QUALITY PROTEIN: H-2 class II histocompatibility antigen, I-E beta chain-like [KO:K06752]
130582771  RAB5A; ras-related protein Rab-5A [KO:K07887]
130586890  ras-related protein Rab-5B-like [KO:K07888]
130588081  ras-related protein Rab-5B [KO:K07888]
130581432  RAB5C; ras-related protein Rab-5C [KO:K07889]
130581040  early endosome antigen 1-like [KO:K12478]
130584511  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
130574163  TFRC; transferrin receptor protein 1 [KO:K06503]
130582004  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
130584425  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
130586443  ATP6V1B2; LOW QUALITY PROTEIN: V-type proton ATPase subunit B, brain isoform [KO:K02147]
130576100  ATP6V1C2; V-type proton ATPase subunit C 2 [KO:K02148]
130577248  ATP6V1C1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
130574328  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
130588979  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
130585776  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
130572523  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
130582931  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
130585885  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
130582240  V-type proton ATPase subunit e 2 [KO:K02153]
130585542  ATP6V0A4; V-type proton ATPase 116 kDa subunit a 4 [KO:K02154]
130580993  ATP6V0A2; V-type proton ATPase 116 kDa subunit a 2 [KO:K02154]
130581441  ATP6V0A1; V-type proton ATPase 116 kDa subunit a 1 [KO:K02154]
130583338  TCIRG1; V-type proton ATPase 116 kDa subunit a 3 [KO:K02154]
130576441  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
130579541  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
130574850  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
130583986  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit c [KO:K02155]
130589321  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit c'' [KO:K03661]
130580812  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
130589087  RAB7A; ras-related protein Rab-7a [KO:K07897]
130585763  RAB7B; ras-related protein Rab-7b isoform X1 [KO:K07898]
130582698  RILP; rab-interacting lysosomal protein isoform X1 [KO:K13883]
130573369  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
130576290  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 [KO:K10414]
130576199  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
130581189  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
130577372  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
130577384  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
130587125  tubulin alpha-3 chain [KO:K07374]
130588489  tubulin alpha-1B chain-like [KO:K07374]
130588975  TUBA8; tubulin alpha-8 chain [KO:K07374]
130578335  tubulin alpha-8 chain isoform X1 [KO:K07374]
130584130  tubulin alpha-1B chain-like [KO:K07374]
130584135  tubulin alpha-1A chain [KO:K07374]
130574397  TUBA4A; tubulin alpha-4A chain [KO:K07374]
130584923  tubulin alpha-3 chain-like [KO:K07374]
130575201  TUBB6; tubulin beta-6 chain [KO:K07375]
130575332  tubulin beta-2 chain [KO:K07375]
130580545  TUBB1; tubulin beta-1 chain [KO:K07375]
130580693  TUBB4B; tubulin beta-4B chain [KO:K07375]
130586773  tubulin beta-2 chain-like [KO:K07375]
130587627  tubulin beta-1 chain [KO:K07375]
130584294  TUBB3; LOW QUALITY PROTEIN: tubulin beta-3 chain [KO:K07375]
130573300  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
130572220  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
130579184  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
130580139  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
130574635  myeloperoxidase-like [KO:K10789] [EC:1.11.2.2]
130574636  eosinophil peroxidase-like [KO:K10789] [EC:1.11.2.2]
130575826  CTSL; procathepsin L [KO:K01365] [EC:3.4.22.15]
130585393  SEC61A2; protein transport protein Sec61 subunit alpha [KO:K10956]
130589093  SEC61A1; protein transport protein Sec61 subunit alpha [KO:K10956]
130574860  SEC61B; protein transport protein Sec61 subunit beta isoform X1 [KO:K09481]
130573113  SEC61G; protein transport protein Sec61 subunit gamma [KO:K07342]
130588090  CALR; calreticulin [KO:K08057]
130579330  CANX; calnexin [KO:K08054]
130587191  Fc receptor-like protein 3 [KO:K06498]
130574812  C1R; complement C1r subcomponent [KO:K01330] [EC:3.4.21.41]
130588864  ITGB2; integrin beta-2 [KO:K06464]
130576801  COLEC11; collectin-11 isoform X1 [KO:K10066]
130572899  COLEC12; collectin-12 [KO:K10062]
130573040  LOW QUALITY PROTEIN: mannose-binding protein-like [KO:K03991]
130573041  pulmonary surfactant-associated protein A-like [KO:K10067]
130573061  pulmonary surfactant-associated protein A-like [KO:K10067]
130583831  ITGAV; integrin alpha-V [KO:K06487]
130585879  ITGA2; integrin alpha-2 [KO:K06481]
130579596  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
130583463  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
130574996  ITGB5; integrin beta-5 [KO:K06588]
130578754  THBS1; thrombospondin-1 [KO:K16857]
130585359  COMP; LOW QUALITY PROTEIN: cartilage oligomeric matrix protein [KO:K04659]
130587939  thrombospondin-4-like [KO:K04659]
130572281  THBS4; thrombospondin-4 [KO:K04659]
130577928  THBS2; thrombospondin-2 isoform X1 [KO:K04659]
130584668  THBS3; thrombospondin-3 [KO:K04659]
130579325  TLR2; toll-like receptor 2 [KO:K10159]
130576764  toll-like receptor 6 [KO:K10169]
130580416  TLR4; toll-like receptor 4 [KO:K10160]
130583460  MRC2; C-type mannose receptor 2 [KO:K06560]
130583833  macrophage mannose receptor 1-like [KO:K06560]
130583842  macrophage mannose receptor 1-like isoform X1 [KO:K06560]
130583856  macrophage mannose receptor 1-like isoform X1 [KO:K06560]
130584371  macrophage mannose receptor 1-like [KO:K06560]
130584379  macrophage mannose receptor 1-like [KO:K06560]
130574415  PLA2R1; secretory phospholipase A2 receptor [KO:K06560]
130587633  hepatic lectin-like [KO:K06563]
130587760  hepatic lectin-like [KO:K06563]
130579716  MARCO; macrophage receptor MARCO isoform X1 [KO:K13884]
130580982  SCARB1; scavenger receptor class B member 1 isoform X1 [KO:K13885]
130584467  cytochrome b-245 light chain [KO:K08009]
130581939  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
130582230  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
130583902  NCF1; neutrophil cytosol factor 1 [KO:K08011]
130581557  NCF2; neutrophil cytosol factor 2 [KO:K08010]
130586678  NCF4; neutrophil cytosol factor 4 isoform X1 [KO:K08012]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
mmea04142  Lysosome
mmea04144  Endocytosis
mmea04620  Toll-like receptor signaling pathway
KO pathway
ko04145   
LinkDB

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