KEGG   PATHWAY: mmma00983
Entry
mmma00983                   Pathway                                
Name
Drug metabolism - other enzymes - Marmota marmota marmota (Alpine marmot)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
mmma00983  Drug metabolism - other enzymes
mmma00983

Organism
Marmota marmota marmota (Alpine marmot) [GN:mmma]
Gene
107159565  Hprt1; hypoxanthine-guanine phosphoribosyltransferase isoform X1 [KO:K00760] [EC:2.4.2.8]
107143500  Impdh2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
107144524  Impdh1; LOW QUALITY PROTEIN: inosine-5'-monophosphate dehydrogenase 1 [KO:K00088] [EC:1.1.1.205]
107143126  Gmps; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
107149281  Tpmt; thiopurine S-methyltransferase isoform X1 [KO:K00569] [EC:2.1.1.67]
107137376  Xdh; xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
107139551  Itpa; inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
107144854  liver carboxylesterase 1-like isoform X3 [KO:K01044] [EC:3.1.1.1]
107144855  liver carboxylesterase 1-like isoform X1 [KO:K01044] [EC:3.1.1.1]
107144859  liver carboxylesterase 1-like isoform X1 [KO:K01044] [EC:3.1.1.1]
107144789  cocaine esterase-like isoform X4 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
107144792  cocaine esterase-like isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
107144794  cocaine esterase-like isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
107144795  cocaine esterase-like isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
107144796  cocaine esterase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
107151010  cocaine esterase-like isoform X6 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
125610346  pyrethroid hydrolase Ces2e-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
107151077  cocaine esterase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
107138814  UDP-glucuronosyltransferase 1-6 isoform X1 [KO:K00699] [EC:2.4.1.17]
107138816  UDP-glucuronosyltransferase 1A8-like [KO:K00699] [EC:2.4.1.17]
107138818  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1A8-like [KO:K00699] [EC:2.4.1.17]
107139268  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
107139272  UDP-glucuronosyltransferase 2B31-like isoform X1 [KO:K00699] [EC:2.4.1.17]
107133871  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
107134958  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
107138815  UDP-glucuronosyltransferase 1-2-like [KO:K00699] [EC:2.4.1.17]
107158795  UDP-glucuronosyltransferase 2A3-like isoform X1 [KO:K00699] [EC:2.4.1.17]
107158800  UDP-glucuronosyltransferase 2B15-like isoform X1 [KO:K00699] [EC:2.4.1.17]
107139271  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
107139270  UDP-glucuronosyltransferase 2B31-like isoform X1 [KO:K00699] [EC:2.4.1.17]
107147006  Gusb; beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
107142170  Cda; cytidine deaminase isoform X1 [KO:K01489] [EC:3.5.4.5]
107160226  thymidine phosphorylase [KO:K00758] [EC:2.4.2.4]
107155044  Dpyd; dihydropyrimidine dehydrogenase [NADP(+)] isoform X1 [KO:K00207] [EC:1.3.1.2]
107142855  Dpys; dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
107154650  Upb1; beta-ureidopropionase isoform X1 [KO:K01431] [EC:3.5.1.6]
107146246  Upp1; uridine phosphorylase 1 isoform X1 [KO:K00757] [EC:2.4.2.3]
107136630  Upp2; LOW QUALITY PROTEIN: uridine phosphorylase 2 [KO:K00757] [EC:2.4.2.3]
107135918  Uckl1; uridine-cytidine kinase-like 1 isoform X4 [KO:K00876] [EC:2.7.1.48]
107147248  Uck2; uridine-cytidine kinase 2 [KO:K00876] [EC:2.7.1.48]
107151986  Uck1; uridine-cytidine kinase 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
107144805  Tk2; thymidine kinase 2, mitochondrial isoform X2 [KO:K00857] [EC:2.7.1.21]
107157737  Tk1; thymidine kinase, cytosolic [KO:K00857] [EC:2.7.1.21]
107143231  Umps; uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
107141787  Cmpk1; UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
107135576  Rrm1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
107142842  Rrm2b; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
107137505  Rrm2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
107143525  Nme6; nucleoside diphosphate kinase 6 isoform X1 [KO:K00940] [EC:2.7.4.6]
107150435  Nme2; nucleoside diphosphate kinase B isoform X2 [KO:K00940] [EC:2.7.4.6]
107146788  Nme4; nucleoside diphosphate kinase, mitochondrial isoform X2 [KO:K00940] [EC:2.7.4.6]
107147405  Nme7; nucleoside diphosphate kinase 7 isoform X5 [KO:K00940] [EC:2.7.4.6]
107154553  nucleoside diphosphate kinase, mitochondrial-like [KO:K00940] [EC:2.7.4.6]
107138123  Dut; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X2 [KO:K01520] [EC:3.6.1.23]
107150408  Mpo; myeloperoxidase isoform X1 [KO:K10789] [EC:1.11.2.2]
107153956  arylamine N-acetyltransferase 2 [KO:K00622] [EC:2.3.1.5]
107153957  arylamine N-acetyltransferase 2-like [KO:K00622] [EC:2.3.1.5]
107152888  cytochrome P450 2E1 isoform X1 [KO:K07415] [EC:1.14.14.-]
107136669  Mgst2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
107149868  Gsto1; glutathione S-transferase omega-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
107149870  Gsto2; glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
107143994  glutathione S-transferase A3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
107143996  glutathione S-transferase alpha-3 [KO:K00799] [EC:2.5.1.18]
107143997  glutathione S-transferase alpha-3-like [KO:K00799] [EC:2.5.1.18]
107143998  glutathione S-transferase alpha-3-like isoform X3 [KO:K00799] [EC:2.5.1.18]
107144001  glutathione S-transferase alpha-3-like [KO:K00799] [EC:2.5.1.18]
107144002  glutathione S-transferase A1 [KO:K00799] [EC:2.5.1.18]
107144003  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
107144096  glutathione S-transferase-like isoform X1 [KO:K00799] [EC:2.5.1.18]
107147437  Mgst3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
107158574  Gstm3; glutathione S-transferase Mu 3 isoform X3 [KO:K00799] [EC:2.5.1.18]
107158576  glutathione S-transferase Mu 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
107158579  glutathione S-transferase Mu 2 [KO:K00799] [EC:2.5.1.18]
107158580  Gstm4; glutathione S-transferase Mu 4 isoform X2 [KO:K00799] [EC:2.5.1.18]
107152703  Mgst1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
107154533  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
107154664  glutathione S-transferase theta-3 [KO:K00799] [EC:2.5.1.18]
107154665  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
107154666  glutathione S-transferase theta-2B-like isoform X1 [KO:K00799] [EC:2.5.1.18]
107157012  Gstp1; glutathione S-transferase P isoform X1 [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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