KEGG   PATHWAY: mphl00230
Entry
mphl00230                   Pathway                                
Name
Purine metabolism - Mycolicibacterium phlei
Class
Metabolism; Nucleotide metabolism
Pathway map
mphl00230  Purine metabolism
mphl00230

Module
mphl_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:mphl00230]
mphl_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:mphl00230]
mphl_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:mphl00230]
mphl_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:mphl00230]
mphl_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:mphl00230]
Other DBs
GO: 0006163 0042278
Organism
Mycolicibacterium phlei [GN:mphl]
Gene
MPHLCCUG_01843  pgm; Phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
MPHLCCUG_04363  prs; Ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
MPHLCCUG_00698  purF; Amidophosphoribosyltransferase precursor [KO:K00764] [EC:2.4.2.14]
MPHLCCUG_00666  purD; Phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
MPHLCCUG_00942  purN; Phosphoribosylglycinamide formyltransferase [KO:K11175] [EC:2.1.2.2]
MPHLCCUG_04660  purT; Phosphoribosylglycinamide formyltransferase 2 [KO:K08289] [EC:6.3.1.21]
MPHLCCUG_00693  purL; Phosphoribosylformylglycinamidine synthase 2 [KO:K23269] [EC:6.3.5.3]
MPHLCCUG_00684  phosphoribosylformylglycinamidine synthase subunit PurS [KO:K23264] [EC:6.3.5.3]
MPHLCCUG_00685  purQ; Phosphoribosylformylglycinamidine synthase 1 [KO:K23265] [EC:6.3.5.3 3.5.1.2]
MPHLCCUG_00702  purM; Phosphoribosylformylglycinamidine cyclo-ligase [KO:K01933] [EC:6.3.3.1]
MPHLCCUG_01616  purK; N5-carboxyaminoimidazole ribonucleotide synthase [KO:K01589] [EC:6.3.4.18]
MPHLCCUG_01617  purE; N5-carboxyaminoimidazole ribonucleotide mutase [KO:K01588] [EC:5.4.99.18]
MPHLCCUG_00675  purC; Phosphoribosylaminoimidazole-succinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
MPHLCCUG_00671  purB; Adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
MPHLCCUG_00943  purH; Bifunctional purine biosynthesis protein PurH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
MPHLCCUG_03017  apt; Adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
MPHLCCUG_01997  5'-nucleotidase [KO:K01081] [EC:3.1.3.5]
MPHLCCUG_02139  nagD_1; Ribonucleotide monophosphatase NagD [KO:K02566] [EC:3.1.3.5]
MPHLCCUG_01522  punA; Purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
MPHLCCUG_03287  yfiH; Laccase domain protein YfiH [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
MPHLCCUG_01462  rihA; Pyrimidine-specific ribonucleoside hydrolase RihA [KO:K01239] [EC:3.2.2.1]
MPHLCCUG_00434  hpt; Hypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
MPHLCCUG_01451  guaB_1; Inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
MPHLCCUG_01452  putative oxidoreductase [KO:K00088] [EC:1.1.1.205]
MPHLCCUG_03596  ndkA; Nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
MPHLCCUG_03877  Non-canonical purine NTP pyrophosphatase [KO:K01519] [EC:3.6.1.66]
MPHLCCUG_01563  xdhA; Xanthine dehydrogenase molybdenum-binding subunit [KO:K11177] [EC:1.17.1.4]
MPHLCCUG_02482  guaA_2; GMP synthase (glutamine-hydrolyzing) [KO:K01951] [EC:6.3.5.2]
MPHLCCUG_01459  guaA_1; GMP synthase (glutamine-hydrolyzing) [KO:K01951] [EC:6.3.5.2]
MPHLCCUG_02365  guaB_2; Inosine-5'-monophosphate dehydrogenase [KO:K26110] [EC:1.7.1.7]
MPHLCCUG_02936  gmk; Guanylate kinase [KO:K00942] [EC:2.7.4.8]
MPHLCCUG_02748  nrdZ; Ribonucleoside-diphosphate reductase NrdZ [KO:K00525] [EC:1.17.4.1]
MPHLCCUG_01952  nrdE2; Ribonucleoside-diphosphate reductase subunit alpha 2 [KO:K00525] [EC:1.17.4.1]
MPHLCCUG_01965  nrdF2; Ribonucleoside-diphosphate reductase subunit beta nrdF2 [KO:K00526] [EC:1.17.4.1]
MPHLCCUG_03455  dgt; Deoxyguanosinetriphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
MPHLCCUG_03016  relA; Bifunctional (p)ppGpp synthase/hydrolase relA [KO:K01139] [EC:2.7.6.5 3.1.7.2]
MPHLCCUG_04506  gppA_2; Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
MPHLCCUG_04353  gppA_1; Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
MPHLCCUG_03993  pH-sensitive adenylate cyclase [KO:K01768] [EC:4.6.1.1]
MPHLCCUG_00417  cyaB_1; Adenylate cyclase 2 [KO:K01768] [EC:4.6.1.1]
MPHLCCUG_02773  cya_2; Adenylate cyclase [KO:K01768] [EC:4.6.1.1]
MPHLCCUG_03830  cyaB_3; Adenylate cyclase 2 [KO:K01768] [EC:4.6.1.1]
MPHLCCUG_04664  purA; Adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
MPHLCCUG_03334  adoK; Adenosine kinase [KO:K00856] [EC:2.7.1.20]
MPHLCCUG_01514  Aminodeoxyfutalosine deaminase [KO:K01488] [EC:3.5.4.4]
MPHLCCUG_01352  adk; Adenylate kinase [KO:K00939] [EC:2.7.4.3]
MPHLCCUG_04358  mazG; Nucleoside triphosphate pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
MPHLCCUG_03043  AP-4-A phosphorylase [KO:K19710] [EC:2.7.7.53]
MPHLCCUG_03955  cysNC; Bifunctional enzyme CysN/CysC [KO:K00955] [EC:2.7.7.4 2.7.1.25]
MPHLCCUG_03956  cysD; Sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
MPHLCCUG_00429  uao; Uric acid degradation bifunctional protein [KO:K16840] [EC:4.1.1.97]
MPHLCCUG_00759  Asp/Glu/Hydantoin racemase [KO:K16841] [EC:5.1.99.3]
MPHLCCUG_00760  pgdA_2; Peptidoglycan deacetylase [KO:K16842] [EC:3.5.2.5]
MPHLCCUG_00761  alc; allantoicase [KO:K01477] [EC:3.5.3.4]
MPHLCCUG_00767  ureC_1; Urease subunit alpha [KO:K01428] [EC:3.5.1.5]
MPHLCCUG_02374  ureC_2; Urease subunit alpha [KO:K01428] [EC:3.5.1.5]
MPHLCCUG_02373  ureB; Urease subunit beta [KO:K01429] [EC:3.5.1.5]
MPHLCCUG_02372  ureA_2; Urease subunit gamma [KO:K01430] [EC:3.5.1.5]
MPHLCCUG_00768  ureA_1; Urease subunit alpha [KO:K14048] [EC:3.5.1.5]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
mphl00030  Pentose phosphate pathway
mphl00220  Arginine biosynthesis
mphl00250  Alanine, aspartate and glutamate metabolism
mphl00260  Glycine, serine and threonine metabolism
mphl00340  Histidine metabolism
mphl00630  Glyoxylate and dicarboxylate metabolism
mphl00730  Thiamine metabolism
mphl00740  Riboflavin metabolism
mphl00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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