KEGG   PATHWAY: mrv00564
Entry
mrv00564                    Pathway                                
Name
Glycerophospholipid metabolism - Mauremys reevesii (Reeves's turtle)
Class
Metabolism; Lipid metabolism
Pathway map
mrv00564  Glycerophospholipid metabolism
mrv00564

Module
mrv_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:mrv00564]
mrv_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:mrv00564]
mrv_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:mrv00564]
Other DBs
GO: 0006650
Organism
Mauremys reevesii (Reeves's turtle) [GN:mrv]
Gene
120391340  GPD1; glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic [KO:K00006] [EC:1.1.1.8]
120375032  glycerol-3-phosphate dehydrogenase 1-like protein isoform X1 [KO:K00006] [EC:1.1.1.8]
120398773  GPD1L; glycerol-3-phosphate dehydrogenase 1-like protein isoform X1 [KO:K00006] [EC:1.1.1.8]
120374773  GPD2; glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1 [KO:K00111] [EC:1.1.5.3]
120398338  GPAT2; glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X1 [KO:K00629] [EC:2.3.1.15]
120409562  GPAM; glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X1 [KO:K00629] [EC:2.3.1.15]
120407002  GPAT3; glycerol-3-phosphate acyltransferase 3 [KO:K13506] [EC:2.3.1.15]
120398730  GPAT4; glycerol-3-phosphate acyltransferase 4 [KO:K13506] [EC:2.3.1.15]
120392455  AGPAT1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha [KO:K13509] [EC:2.3.1.51]
120386607  AGPAT2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta [KO:K13509] [EC:2.3.1.51]
120389177  AGPAT3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
120400712  AGPAT4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X1 [KO:K13523] [EC:2.3.1.51 2.3.1.-]
120402108  AGPAT5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X1 [KO:K19007] [EC:2.3.1.51]
120400961  LCLAT1; lysocardiolipin acyltransferase 1 isoform X1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
120399468  MBOAT1; lysophospholipid acyltransferase 1 isoform X1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
120400415  MBOAT2; lysophospholipid acyltransferase 2 isoform X1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
120401716  GNPAT; dihydroxyacetone phosphate acyltransferase isoform X1 [KO:K00649] [EC:2.3.1.42]
120383222  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
120391484  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
120391866  PLPP2; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
120371180  PLPP3; phospholipid phosphatase 3 isoform X1 [KO:K01080] [EC:3.1.3.4]
120408723  PLPP1; phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
120401098  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
120397031  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
120380219  LPIN3; phosphatidate phosphatase LPIN3 [KO:K15728] [EC:3.1.3.4]
120397685  PLPP5; phospholipid phosphatase 5 isoform X1 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
120408977  PLPP4; phospholipid phosphatase 4 isoform X1 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
120383433  DGKE; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
120371450  DGKD; diacylglycerol kinase delta isoform X1 [KO:K00901] [EC:2.7.1.107]
120402962  DGKZ; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
120371891  DGKK; diacylglycerol kinase kappa isoform X1 [KO:K00901] [EC:2.7.1.107]
120371984  DGKG; diacylglycerol kinase gamma isoform X1 [KO:K00901] [EC:2.7.1.107]
120395635  DGKI; diacylglycerol kinase iota isoform X1 [KO:K00901] [EC:2.7.1.107]
120397561  DGKB; diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
120376294  DGKH; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
120407308  DGKQ; diacylglycerol kinase theta [KO:K00901] [EC:2.7.1.107]
120390992  DGKA; diacylglycerol kinase alpha [KO:K00901] [EC:2.7.1.107]
120369887  CHPT1; cholinephosphotransferase 1 [KO:K00994] [EC:2.7.8.2]
120403809  CEPT1; choline/ethanolaminephosphotransferase 1 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
120368723  SAMD8; sphingomyelin synthase-related protein 1 isoform X1 [KO:K22697] [EC:3.1.4.62]
120406220  SGMS2; phosphatidylcholine:ceramide cholinephosphotransferase 2 isoform X1 [KO:K04714] [EC:2.7.8.27 3.1.4.62]
120368753  SGMS1; phosphatidylcholine:ceramide cholinephosphotransferase 1 [KO:K04714] [EC:2.7.8.27 3.1.4.62]
120372696  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
120381526  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
120403111  PLD4; 5'-3' exonuclease PLD4 [KO:K16860] [EC:3.1.4.4]
120388567  PLD3; 5'-3' exonuclease PLD3 [KO:K16860] [EC:3.1.4.4]
120408979  5'-3' exonuclease PLD3-like isoform X1 [KO:K16860] [EC:3.1.4.4]
120384199  LCAT; phosphatidylcholine-sterol acyltransferase isoform X1 [KO:K00650] [EC:2.3.1.43]
120383866  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
120403628  phospholipase A2, minor isoenzyme-like [KO:K01047] [EC:3.1.1.4]
120372808  PLA2G10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
120385887  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
120385957  PLA2G1B; phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
120387557  PROCA1; protein PROCA1 [KO:K01047] [EC:3.1.1.4]
120387728  group IID secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
120387729  group IIF secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
120369488  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
120392593  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
120403377  PLA2G4B; LOW QUALITY PROTEIN: cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
120384955  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
120404423  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
120404471  LOW QUALITY PROTEIN: cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
120404486  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
120404503  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
120404532  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
120404546  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
120405295  cytosolic phospholipase A2 zeta-like isoform X1 [KO:K16342] [EC:3.1.1.4]
120380092  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
120380093  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
120380100  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
120380338  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
120380930  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
120370232  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
120384418  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 [KO:K16343] [EC:3.1.1.4]
120402058  PLB1; phospholipase B1, membrane-associated isoform X1 [KO:K14621] [EC:3.1.1.4 3.1.1.5]
120388009  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
120368604  phospholipase A and acyltransferase 3-like isoform X1 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
120368605  phospholipase A and acyltransferase 3-like isoform X1 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
120368606  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
120368607  phospholipase A and acyltransferase 3-like isoform X1 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
120369472  phospholipase A and acyltransferase 3-like isoform X1 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
120384617  LPCAT2; lysophosphatidylcholine acyltransferase 2 isoform X1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
120398137  LPCAT1; lysophosphatidylcholine acyltransferase 1 isoform X1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
120379869  LPCAT4; lysophospholipid acyltransferase LPCAT4 [KO:K13512] [EC:2.3.1.23 2.3.1.-]
120401912  LPCAT3; lysophospholipid acyltransferase 5 isoform X1 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
120398041  LYPLA1; acyl-protein thioesterase 1 [KO:K06128] [EC:3.1.1.5]
120384301  PLA2G15; phospholipase A2 group XV [KO:K06129] [EC:3.1.1.5]
120389353  LYPLA2; acyl-protein thioesterase 2 isoform X1 [KO:K06130] [EC:3.1.1.5]
120386682  PNPLA7; patatin-like phospholipase domain-containing protein 7 isoform X1 [KO:K14676] [EC:3.1.1.5]
120390907  PNPLA6; patatin-like phospholipase domain-containing protein 6 isoform X1 [KO:K14676] [EC:3.1.1.5]
120400178  GPCPD1; glycerophosphocholine phosphodiesterase GPCPD1 [KO:K18695] [EC:3.1.4.2]
120369091  CHAT; choline O-acetyltransferase [KO:K00623] [EC:2.3.1.6]
120382950  acetylcholinesterase-like [KO:K01049] [EC:3.1.1.7]
120383003  LOW QUALITY PROTEIN: acetylcholinesterase-like [KO:K01049] [EC:3.1.1.7]
120383413  acetylcholinesterase-like [KO:K01049] [EC:3.1.1.7]
120383466  LOW QUALITY PROTEIN: acetylcholinesterase-like [KO:K01049] [EC:3.1.1.7]
120383467  acetylcholinesterase-like [KO:K01049] [EC:3.1.1.7]
120383521  acetylcholinesterase-like [KO:K01049] [EC:3.1.1.7]
120383605  acetylcholinesterase-like [KO:K01049] [EC:3.1.1.7]
120383695  acetylcholinesterase-like [KO:K01049] [EC:3.1.1.7]
120383705  acetylcholinesterase-like [KO:K01049] [EC:3.1.1.7]
120383856  acetylcholinesterase-like isoform X1 [KO:K01049] [EC:3.1.1.7]
120383857  acetylcholinesterase-like [KO:K01049] [EC:3.1.1.7]
120383858  acetylcholinesterase-like [KO:K01049] [EC:3.1.1.7]
120384053  acetylcholinesterase-like [KO:K01049] [EC:3.1.1.7]
120381887  ACHE; acetylcholinesterase isoform X1 [KO:K01049] [EC:3.1.1.7]
120383468  cholinesterase-like [KO:K01049] [EC:3.1.1.7]
120403286  CHKA; choline kinase alpha [KO:K14156] [EC:2.7.1.32 2.7.1.82]
120396027  CHKB; LOW QUALITY PROTEIN: choline/ethanolamine kinase [KO:K14156] [EC:2.7.1.32 2.7.1.82]
120392168  PHOSPHO1; phosphoethanolamine/phosphocholine phosphatase [KO:K06124] [EC:3.1.3.75]
120372019  PCYT1A; choline-phosphate cytidylyltransferase A isoform X1 [KO:K00968] [EC:2.7.7.15]
120372580  PCYT1B; choline-phosphate cytidylyltransferase B isoform X1 [KO:K00968] [EC:2.7.7.15]
120401316  SELENOI; ethanolaminephosphotransferase 1 [KO:K00993] [EC:2.7.8.1]
120404731  ETNK2; ethanolamine kinase 2 [KO:K00894] [EC:2.7.1.82]
120407594  ETNK1; ethanolamine kinase 1 isoform X1 [KO:K00894] [EC:2.7.1.82]
120383045  PCYT2; ethanolamine-phosphate cytidylyltransferase isoform X1 [KO:K00967] [EC:2.7.7.14]
120406734  ETNPPL; ethanolamine-phosphate phospho-lyase isoform X1 [KO:K14286] [EC:4.2.3.2]
120373546  PEMT; phosphatidylethanolamine N-methyltransferase isoform X1 [KO:K00551] [EC:2.1.1.17 2.1.1.71]
120397948  CDS2; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
120406536  CDS1; phosphatidate cytidylyltransferase 1 isoform X1 [KO:K00981] [EC:2.7.7.41]
120408550  PLA1A; phospholipase A1 member A isoform X1 [KO:K13618] [EC:3.1.1.111]
120397201  PTDSS1; phosphatidylserine synthase 1 isoform X1 [KO:K08729] [EC:2.7.8.-]
120403852  PTDSS2; phosphatidylserine synthase 2 isoform X1 [KO:K08730] [EC:2.7.8.29]
120403186  phosphatidylserine decarboxylase proenzyme, mitochondrial-like isoform X1 [KO:K01613] [EC:4.1.1.65]
120386387  PISD; phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X1 [KO:K01613] [EC:4.1.1.65]
120383420  PGS1; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial isoform X1 [KO:K00995] [EC:2.7.8.5]
120402018  CRLS1; cardiolipin synthase (CMP-forming) [KO:K08744] [EC:2.7.8.41]
120388648  TAZ; tafazzin isoform X1 [KO:K13511] [EC:2.3.1.-]
120401522  LPGAT1; acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X1 [KO:K13514] [EC:2.3.1.-]
120402847  CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
120388276  MBOAT7; lysophospholipid acyltransferase 7 [KO:K13516] [EC:2.3.1.-]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
mrv00010  Glycolysis / Gluconeogenesis
mrv00260  Glycine, serine and threonine metabolism
mrv00561  Glycerolipid metabolism
mrv00562  Inositol phosphate metabolism
mrv00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
mrv00565  Ether lipid metabolism
mrv00620  Pyruvate metabolism
KO pathway
ko00564   
LinkDB

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