KEGG   PATHWAY: mthb00983
Entry
mthb00983                   Pathway                                
Name
Drug metabolism - other enzymes - Macaca thibetana thibetana (Pere David's macaque)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
mthb00983  Drug metabolism - other enzymes
mthb00983

Organism
Macaca thibetana thibetana (Pere David's macaque) [GN:mthb]
Gene
126946697  hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
126949778  inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
126945314  inosine-5'-monophosphate dehydrogenase 1-like [KO:K00088] [EC:1.1.1.205]
126948662  inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
126947519  GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
126953256  thiopurine S-methyltransferase isoform X1 [KO:K00569] [EC:2.1.1.67]
126933515  xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
126929409  inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
126943833  liver carboxylesterase 1 isoform X1 [KO:K01044] [EC:3.1.1.1]
126943835  liver carboxylesterase 1-like isoform X1 [KO:K01044] [EC:3.1.1.1]
126943848  liver carboxylesterase 1-like [KO:K01044] [EC:3.1.1.1]
126945004  cocaine esterase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
126945006  cocaine esterase isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
126955122  UDP-glucuronosyltransferase 2A1 isoform X1 [KO:K00699] [EC:2.4.1.17]
126955126  UDP-glucuronosyltransferase 2B20 [KO:K00699] [EC:2.4.1.17]
126955127  UDP-glucuronosyltransferase 2B23 isoform X1 [KO:K00699] [EC:2.4.1.17]
126955129  UDP-glucuronosyltransferase 2B19 [KO:K00699] [EC:2.4.1.17]
126955130  UDP-glucuronosyltransferase 2B4 isoform X1 [KO:K00699] [EC:2.4.1.17]
126955131  UDP-glucuronosyltransferase 2A3 [KO:K00699] [EC:2.4.1.17]
126932167  UDP-glucuronosyltransferase 1A7-like [KO:K00699] [EC:2.4.1.17]
126933130  UDP-glucuronosyltransferase 1A1 isoform X1 [KO:K00699] [EC:2.4.1.17]
126933131  UDP-glucuronosyltransferase 1A8-like [KO:K00699] [EC:2.4.1.17]
126950295  beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
126950475  cytochrome P450 3A8 isoform X1 [KO:K17689] [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
126956441  cytidine deaminase [KO:K01489] [EC:3.5.4.5]
126929443  thymidine phosphorylase [KO:K00758] [EC:2.4.2.4]
126964310  dihydropyrimidine dehydrogenase [NADP(+)] isoform X1 [KO:K00207] [EC:1.3.1.2]
126960882  dihydropyrimidinase isoform X1 [KO:K01464] [EC:3.5.2.2]
126929659  beta-ureidopropionase isoform X1 [KO:K01431] [EC:3.5.1.6]
126932042  uridine phosphorylase 2 isoform X1 [KO:K00757] [EC:2.4.2.3]
126951453  uridine phosphorylase 1 isoform X1 [KO:K00757] [EC:2.4.2.3]
126937058  uridine-cytidine kinase 1 [KO:K00876] [EC:2.7.1.48]
126941880  uridine-cytidine kinase 2 [KO:K00876] [EC:2.7.1.48]
126929621  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
126945023  thymidine kinase 2, mitochondrial isoform X1 [KO:K00857] [EC:2.7.1.21]
126939270  thymidine kinase, cytosolic [KO:K00857] [EC:2.7.1.21]
126949128  uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
126931210  UMP-CMP kinase isoform X1 [KO:K13800] [EC:2.7.4.14]
126960799  UMP-CMP kinase-like [KO:K13800] [EC:2.7.4.14]
126935035  ribonucleoside-diphosphate reductase large subunit isoform X1 [KO:K10807] [EC:1.17.4.1]
126933789  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
126960886  LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
126937475  nucleoside diphosphate kinase B-like [KO:K00940] [EC:2.7.4.6]
126944759  nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
126944879  nucleoside diphosphate kinase, mitochondrial isoform X1 [KO:K00940] [EC:2.7.4.6]
126939625  nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
126939627  nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
126950762  nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
126953145  nucleoside diphosphate kinase A-like [KO:K00940] [EC:2.7.4.6]
126948742  nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
126958705  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 [KO:K01520] [EC:3.6.1.23]
126941797  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like [KO:K01520] [EC:3.6.1.23]
126939378  myeloperoxidase isoform X1 [KO:K10789] [EC:1.11.2.2]
126961452  arylamine N-acetyltransferase 1 [KO:K00622] [EC:2.3.1.5]
126961453  arylamine N-acetyltransferase 2 [KO:K00622] [EC:2.3.1.5]
126963293  LOW QUALITY PROTEIN: cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
126963295  cytochrome P450 2E1-like isoform X1 [KO:K07415] [EC:1.14.14.-]
126930060  glutathione S-transferase Mu 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
126930154  glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
126930168  glutathione S-transferase Mu 5 [KO:K00799] [EC:2.5.1.18]
126954620  microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
126931359  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
126963047  glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
126963049  glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
126946285  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
126952227  glutathione S-transferase A1-like [KO:K00799] [EC:2.5.1.18]
126941935  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
126929522  glutathione S-transferase theta-4-like [KO:K00799] [EC:2.5.1.18]
126929523  glutathione S-transferase theta-2B [KO:K00799] [EC:2.5.1.18]
126929524  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
126929525  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
126953690  glutathione S-transferase A1 isoform X1 [KO:K00799] [EC:2.5.1.18]
126953691  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
126953692  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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