KEGG   PATHWAY: mtv00630
Entry
mtv00630                    Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Mycobacterium tuberculosis H37Rv
Class
Metabolism; Carbohydrate metabolism
Pathway map
mtv00630  Glyoxylate and dicarboxylate metabolism
mtv00630

Module
mtv_M00012  Glyoxylate cycle [PATH:mtv00630]
mtv_M00621  Glycine cleavage system [PATH:mtv00630]
mtv_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:mtv00630]
Other DBs
GO: 0046487 0043648
Organism
Mycobacterium tuberculosis H37Rv [GN:mtv]
Gene
RVBD_0467  isocitrate lyase Icl [KO:K01637] [EC:4.1.3.1 4.1.3.30]
RVBD_1915  isocitrate lyase AceAa [KO:K01637] [EC:4.1.3.1 4.1.3.30]
RVBD_1916  isocitrate lyase AceAb [KO:K01637] [EC:4.1.3.1 4.1.3.30]
RVBD_3667  acetyl-CoA synthetase Acs [KO:K01895] [EC:6.2.1.1]
RVBD_1837c  malate synthase G GlcB [KO:K01638] [EC:2.3.3.9]
RVBD_1240  malate dehydrogenase Mdh [KO:K00024] [EC:1.1.1.37]
RVBD_0889c  citrate synthase II CitA [KO:K01647] [EC:2.3.3.1]
RVBD_0896  citrate synthase I GltA2 [KO:K01647] [EC:2.3.3.1]
RVBD_1131  methylcitrate synthase PrpC [KO:K01659] [EC:2.3.3.5]
RVBD_1475c  iron-regulated aconitate hydratase Can [KO:K27802] [EC:4.2.1.3 4.2.1.99]
RVBD_0243  acetyl-CoA acyltransferase FadA2 [KO:K00626] [EC:2.3.1.9]
RVBD_0859  acyl-CoA thiolase FadA [KO:K00626] [EC:2.3.1.9]
RVBD_1074c  beta-ketoacyl CoA thiolase FadA3 [KO:K00626] [EC:2.3.1.9]
RVBD_0914c  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
RVBD_1323  acetyl-CoA acetyltransferase FadA4 [KO:K00626] [EC:2.3.1.9]
RVBD_1867  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
RVBD_3523  lipid carrier protein or keto acyl-CoA thiolase Ltp3 [KO:K00626] [EC:2.3.1.9]
RVBD_3546  acetyl-CoA acetyltransferase FadA5 [KO:K00626] [EC:2.3.1.9]
RVBD_3556c  acetyl-CoA acetyltransferase FadA6 [KO:K00626] [EC:2.3.1.9]
RVBD_1322A  methylmalonyl-CoA epimerase [KO:K05606] [EC:5.1.99.1]
RVBD_3285  acetyl-/propionyl-coenzyme A carboxylase AccA3 [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.4.1.- 6.3.4.14]
RVBD_3280  propionyl-CoA carboxylase beta chain 5 AccD5 [KO:K27094] [EC:6.4.1.3 6.4.1.- 2.1.3.15]
RVBD_3281  acetyl-/propionyl-coenzyme A carboxylase AccE5 [KO:K27095]
RVBD_2247  propionyl-CoA carboxylase beta chain 6 AccD6 [KO:K18472] [EC:6.4.1.2 6.4.1.3 2.1.3.15]
RVBD_1492  methylmalonyl-CoA mutase small subunit MutA [KO:K01847] [EC:5.4.99.2]
RVBD_1493  methylmalonyl-CoA mutase large subunit MutB [KO:K01847] [EC:5.4.99.2]
RVBD_1257c  glycolate oxidase subunit GlcD [KO:K00104] [EC:1.1.99.14]
RVBD_2280  glycolate oxidase subunit GlcD [KO:K00104] [EC:1.1.99.14]
RVBD_2220  glutamine synthetase GlnA1 [KO:K01915] [EC:6.3.1.2]
RVBD_2222c  glutamine synthetase GlnA2 [KO:K01915] [EC:6.3.1.2]
RVBD_2860c  glutamine synthetase GlnA4 [KO:K01915] [EC:6.3.1.2]
RVBD_1878  glutamine synthetase GlnA3 [KO:K01915] [EC:6.3.1.2]
RVBD_0070c  serine hydroxymethyltransferase GlyA2 [KO:K00600] [EC:2.1.2.1]
RVBD_1093  serine hydroxymethyltransferase 1 GlyA1 [KO:K00600] [EC:2.1.2.1]
RVBD_1832  glycine dehydrogenase GcvB [KO:K00281] [EC:1.4.4.2]
RVBD_2211c  aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
RVBD_0462  dihydrolipoamide dehydrogenase LpdC [KO:K00382] [EC:1.8.1.4]
RVBD_1826  glycine cleavage system H protein GcvH [KO:K02437]
RVBD_2205c  glycerate kinase [KO:K00865] [EC:2.7.1.165]
RVBD_1248c  2-oxoglutarate decarboxylase [KO:K01616] [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
RVBD_2964  formyltetrahydrofolate deformylase PurU [KO:K01433] [EC:3.5.1.10]
RVBD_0118c  oxalyl-CoA decarboxylase OxcA [KO:K01577] [EC:4.1.1.8]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
mtv00010  Glycolysis / Gluconeogenesis
mtv00020  Citrate cycle (TCA cycle)
mtv00030  Pentose phosphate pathway
mtv00053  Ascorbate and aldarate metabolism
mtv00071  Fatty acid degradation
mtv00230  Purine metabolism
mtv00250  Alanine, aspartate and glutamate metabolism
mtv00260  Glycine, serine and threonine metabolism
mtv00620  Pyruvate metabolism
mtv00710  Carbon fixation by Calvin cycle
mtv00750  Vitamin B6 metabolism
mtv00910  Nitrogen metabolism
KO pathway
ko00630   
LinkDB

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