KEGG   PATHWAY: nni00564
Entry
nni00564                    Pathway                                
Name
Glycerophospholipid metabolism - Nipponia nippon (crested ibis)
Class
Metabolism; Lipid metabolism
Pathway map
nni00564  Glycerophospholipid metabolism
nni00564

Module
nni_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:nni00564]
nni_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:nni00564]
nni_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:nni00564]
Other DBs
GO: 0006650
Organism
Nipponia nippon (crested ibis) [GN:nni]
Gene
104013878  GPD1L; glycerol-3-phosphate dehydrogenase 1-like protein [KO:K00006] [EC:1.1.1.8]
104018741  glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic-like [KO:K00006] [EC:1.1.1.8]
104011969  GPD1; glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic isoform X1 [KO:K00006] [EC:1.1.1.8]
104012349  GPD2; glycerol-3-phosphate dehydrogenase, mitochondrial [KO:K00111] [EC:1.1.5.3]
104022622  GPAT2; glycerol-3-phosphate acyltransferase 2, mitochondrial [KO:K00629] [EC:2.3.1.15]
104022331  GPAM; glycerol-3-phosphate acyltransferase 1, mitochondrial [KO:K00629] [EC:2.3.1.15]
104014875  glycerol-3-phosphate acyltransferase 3 [KO:K13506] [EC:2.3.1.15]
104014885  glycerol-3-phosphate acyltransferase 3-like [KO:K13506] [EC:2.3.1.15]
104016026  AGPAT6; glycerol-3-phosphate acyltransferase 6 [KO:K13506] [EC:2.3.1.15]
104012464  LOW QUALITY PROTEIN: 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha-like [KO:K13509] [EC:2.3.1.51]
104023295  AGPAT2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta [KO:K13509] [EC:2.3.1.51]
104012269  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha-like [KO:K13509] [EC:2.3.1.51]
104018075  AGPAT4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [KO:K13523] [EC:2.3.1.51 2.3.1.-]
104020854  AGPAT3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
104009379  AGPAT5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [KO:K19007] [EC:2.3.1.51]
104019265  LCLAT1; lysocardiolipin acyltransferase 1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
104021879  MBOAT1; lysophospholipid acyltransferase 1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
104013003  MBOAT2; lysophospholipid acyltransferase 2 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
104018264  GNPAT; dihydroxyacetone phosphate acyltransferase [KO:K00649] [EC:2.3.1.42]
104014562  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
104016268  PPAP2C; lipid phosphate phosphohydrolase 2 [KO:K01080] [EC:3.1.3.4]
104013735  PPAP2A; lipid phosphate phosphohydrolase 1 [KO:K01080] [EC:3.1.3.4]
104009343  PPAP2B; lipid phosphate phosphohydrolase 3 [KO:K01080] [EC:3.1.3.4]
104009591  LPIN3; phosphatidate phosphatase LPIN3 [KO:K15728] [EC:3.1.3.4]
104013018  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
104015763  LPIN2; phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
104022396  PPAPDC1A; phosphatidate phosphatase PPAPDC1A [KO:K18693] [EC:3.6.1.75 3.1.3.4]
104016015  PPAPDC1B; LOW QUALITY PROTEIN: phosphatidate phosphatase PPAPDC1B [KO:K18693] [EC:3.6.1.75 3.1.3.4]
104008580  DGKD; diacylglycerol kinase delta [KO:K00901] [EC:2.7.1.107]
104014383  DGKE; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
104012389  DGKI; LOW QUALITY PROTEIN: diacylglycerol kinase iota [KO:K00901] [EC:2.7.1.107]
104012631  DGKK; diacylglycerol kinase kappa [KO:K00901] [EC:2.7.1.107]
104010650  diacylglycerol kinase beta-like isoform X1 [KO:K00901] [EC:2.7.1.107]
104010924  DGKH; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
104009210  DGKB; diacylglycerol kinase beta [KO:K00901] [EC:2.7.1.107]
104020462  DGKZ; diacylglycerol kinase zeta [KO:K00901] [EC:2.7.1.107]
104011950  DGKQ; diacylglycerol kinase theta [KO:K00901] [EC:2.7.1.107]
104013380  CHPT1; cholinephosphotransferase 1 [KO:K00994] [EC:2.7.8.2]
104011091  CEPT1; choline/ethanolaminephosphotransferase 1 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
104022057  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
104020264  PLD3; phospholipase D3 [KO:K16860] [EC:3.1.4.4]
104014540  PLD4; phospholipase D4 [KO:K16860] [EC:3.1.4.4]
104017431  LCAT; phosphatidylcholine-sterol acyltransferase [KO:K00650] [EC:2.3.1.43]
104013509  PLA2G12B; group XIIB secretory phospholipase A2-like protein [KO:K01047] [EC:3.1.1.4]
104011464  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
104012778  PROCA1; protein PROCA1 [KO:K01047] [EC:3.1.1.4]
104014079  group 10 secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
104023502  group 10 secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
104021313  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
104011170  phospholipase A2, membrane associated-like [KO:K01047] [EC:3.1.1.4]
104011172  PLA2G5; calcium-dependent phospholipase A2 [KO:K01047] [EC:3.1.1.4]
104011173  basic phospholipase A2 A-like [KO:K01047] [EC:3.1.1.4]
104020345  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
104020346  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
104020347  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
104020440  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
104020441  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
104020443  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
104020445  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
104011301  PLA2G4A; LOW QUALITY PROTEIN: cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
104021606  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 [KO:K16343] [EC:3.1.1.4]
104013405  LPCAT1; lysophosphatidylcholine acyltransferase 1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
104016459  LPCAT2; lysophosphatidylcholine acyltransferase 2 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
104009773  LPCAT3; lysophospholipid acyltransferase 5 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
104019757  LYPLA1; acyl-protein thioesterase 1 isoform X1 [KO:K06128] [EC:3.1.1.5]
104016464  PLA2G15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
104017743  LYPLA2; acyl-protein thioesterase 2 [KO:K06130] [EC:3.1.1.5]
104014972  PNPLA6; neuropathy target esterase [KO:K14676] [EC:3.1.1.5]
104022277  PNPLA7; patatin-like phospholipase domain-containing protein 7 [KO:K14676] [EC:3.1.1.5]
104014927  GPCPD1; glycerophosphocholine phosphodiesterase GPCPD1 [KO:K18695] [EC:3.1.4.2]
104013529  CHAT; choline O-acetyltransferase [KO:K00623] [EC:2.3.1.6]
104017302  CHKA; choline kinase alpha [KO:K14156] [EC:2.7.1.32 2.7.1.82]
104009629  CHKB; choline/ethanolamine kinase [KO:K14156] [EC:2.7.1.32 2.7.1.82]
104012239  PHOSPHO1; phosphoethanolamine/phosphocholine phosphatase isoform X1 [KO:K06124] [EC:3.1.3.75]
104015661  PCYT1A; choline-phosphate cytidylyltransferase A [KO:K00968] [EC:2.7.7.15]
104022559  PCYT1B; choline-phosphate cytidylyltransferase B [KO:K00968] [EC:2.7.7.15]
104014719  EPT1; ethanolaminephosphotransferase 1 [KO:K00993] [EC:2.7.8.1]
104019770  ethanolaminephosphotransferase 1-like [KO:K00993] [EC:2.7.8.1]
104012706  ETNK1; ethanolamine kinase 1 [KO:K00894] [EC:2.7.1.82]
104013209  ETNK2; ethanolamine kinase 2 [KO:K00894] [EC:2.7.1.82]
104014315  PCYT2; ethanolamine-phosphate cytidylyltransferase isoform X1 [KO:K00967] [EC:2.7.7.14]
104021163  ETNPPL; LOW QUALITY PROTEIN: ethanolamine-phosphate phospho-lyase [KO:K14286] [EC:4.2.3.2]
104015118  PEMT; phosphatidylethanolamine N-methyltransferase [KO:K00551] [EC:2.1.1.17 2.1.1.71]
104017523  CDS2; LOW QUALITY PROTEIN: phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
104021574  CDS1; phosphatidate cytidylyltransferase 1 [KO:K00981] [EC:2.7.7.41]
104008632  PLA1A; phospholipase A1 member A [KO:K13618] [EC:3.1.1.111]
104016509  PTDSS1; phosphatidylserine synthase 1 [KO:K08729] [EC:2.7.8.-]
104011400  PTDSS2; phosphatidylserine synthase 2 [KO:K08730] [EC:2.7.8.29]
104011451  PISD; phosphatidylserine decarboxylase proenzyme [KO:K01613] [EC:4.1.1.65]
104018635  PGS1; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial [KO:K00995] [EC:2.7.8.5]
104014932  CRLS1; cardiolipin synthase [KO:K08744] [EC:2.7.8.41]
104015752  TAZ; tafazzin [KO:K13511] [EC:2.3.1.-]
104019672  LPGAT1; acyl-CoA:lysophosphatidylglycerol acyltransferase 1 [KO:K13514] [EC:2.3.1.-]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
nni00010  Glycolysis / Gluconeogenesis
nni00260  Glycine, serine and threonine metabolism
nni00561  Glycerolipid metabolism
nni00562  Inositol phosphate metabolism
nni00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
nni00565  Ether lipid metabolism
nni00620  Pyruvate metabolism
KO pathway
ko00564   
LinkDB

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