KEGG   PATHWAY: oor04612
Entry
oor04612                    Pathway                                
Name
Antigen processing and presentation - Orcinus orca (killer whale)
Class
Organismal Systems; Immune system
Pathway map
oor04612  Antigen processing and presentation
oor04612

Other DBs
GO: 0019885 0019886 0042591
Organism
Orcinus orca (killer whale) [GN:oor]
Gene
101282933  IFNG; interferon gamma [KO:K04687]
101269870  TNF; tumor necrosis factor [KO:K03156]
101273585  PSME1; proteasome activator complex subunit 1 [KO:K06696]
101273329  PSME2; proteasome activator complex subunit 2 [KO:K06697]
101287944  PSME3; proteasome activator complex subunit 3 isoform X1 [KO:K06698]
101278046  heat shock cognate 71 kDa protein [KO:K03283]
101283817  HSPA1B; heat shock 70 kDa protein 1B [KO:K03283]
101284066  heat shock 70 kDa protein 1B [KO:K03283]
101284311  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
101282770  LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
101284349  heat shock cognate 71 kDa protein-like [KO:K03283]
125963979  LOW QUALITY PROTEIN: heat shock 70 kDa protein 6-like [KO:K03283]
125965152  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
101276206  HSPA2; heat shock-related 70 kDa protein 2 [KO:K26598]
101272709  HSPA4; heat shock 70 kDa protein 4 isoform X1 [KO:K09489]
101285036  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
101278395  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
101271249  LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079]
101271749  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
101276578  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X8 [KO:K06751]
105748394  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X3 [KO:K06751]
125965560  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
101289151  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
101285652  CANX; calnexin isoform X1 [KO:K08054]
101278678  B2M; beta-2-microglobulin [KO:K08055]
101275177  beta-2-microglobulin-like [KO:K08055]
125963661  beta-2-microglobulin [KO:K08055]
101282830  PDIA3; protein disulfide-isomerase A3 isoform X1 [KO:K08056] [EC:5.3.4.1]
101279584  CALR; calreticulin [KO:K08057]
101284313  TAPBP; tapasin isoform X2 [KO:K08058]
101289708  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
101290371  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
101285165  CD8A; T-cell surface glycoprotein CD8 alpha chain isoform X1 [KO:K06458]
101284904  CD8B; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
101276044  NKG2-A/NKG2-B type II integral membrane protein [KO:K06541]
101276292  KLRD1; natural killer cells antigen CD94 [KO:K06516]
101281101  IFI30; gamma-interferon-inducible lysosomal thiol reductase [KO:K08059]
101269340  LGMN; legumain isoform X2 [KO:K01369] [EC:3.4.22.34]
101283436  CTSB; cathepsin B isoform X1 [KO:K01363] [EC:3.4.22.1]
101275987  SLA class II histocompatibility antigen, DQ haplotype D alpha chain isoform X2 [KO:K06752]
101287624  HLA class II histocompatibility antigen, DM beta chain isoform X3 [KO:K06752]
101287882  HLA class II histocompatibility antigen, DO beta chain isoform X1 [KO:K06752]
101277081  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
101276823  DLA class II histocompatibility antigen, DR-1 beta chain isoform X3 [KO:K06752]
101288385  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
101289225  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
101270971  CD74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
101285992  CTSL; procathepsin L isoform X1 [KO:K01365] [EC:3.4.22.15]
101289364  CTSV; cathepsin L2 [KO:K01365] [EC:3.4.22.15]
101269523  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
101285114  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
101290378  CIITA; MHC class II transactivator isoform X1 [KO:K08060] [EC:2.7.11.1]
101278537  RFX5; DNA-binding protein RFX5 isoform X3 [KO:K08061]
101269571  RFXANK; DNA-binding protein RFXANK isoform X1 [KO:K08062]
101287764  RFXAP; regulatory factor X-associated protein [KO:K08063]
101287685  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X2 [KO:K05870]
101278637  NFYA; nuclear transcription factor Y subunit alpha isoform X1 [KO:K08064]
101288651  NFYB; nuclear transcription factor Y subunit beta isoform X2 [KO:K08065]
101279629  NFYC; nuclear transcription factor Y subunit gamma isoform X1 [KO:K08066]
Reference
PMID:15771591
  Authors
Trombetta ES, Mellman I.
  Title
Cell biology of antigen processing in vitro and in vivo.
  Journal
Annu Rev Immunol 23:975-1028 (2005)
DOI:10.1146/annurev.immunol.22.012703.104538
Reference
PMID:15814328
  Authors
Inaba K, Inaba M.
  Title
Antigen recognition and presentation by dendritic cells.
  Journal
Int J Hematol 81:181-7 (2005)
DOI:10.1532/IJH97.04200
Reference
PMID:11905820
  Authors
Heath WR, Carbone FR.
  Title
Cross-presentation in viral immunity and self-tolerance.
  Journal
Nat Rev Immunol 1:126-34 (2001)
DOI:10.1038/35100512
Reference
PMID:15304636
  Authors
Abele R, Tampe R.
  Title
The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing.
  Journal
Physiology (Bethesda) 19:216-24 (2004)
DOI:10.1152/physiol.00002.2004
Reference
PMID:16200082
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
PMID:12776207
  Authors
Honey K, Rudensky AY.
  Title
Lysosomal cysteine proteases regulate antigen presentation.
  Journal
Nat Rev Immunol 3:472-82 (2003)
DOI:10.1038/nri1110
Reference
PMID:12974477
  Authors
Sercarz EE, Maverakis E.
  Title
Mhc-guided processing: binding of large antigen fragments.
  Journal
Nat Rev Immunol 3:621-9 (2003)
DOI:10.1038/nri1149
Reference
PMID:15224093
  Authors
Ackerman AL, Cresswell P.
  Title
Cellular mechanisms governing cross-presentation of exogenous antigens.
  Journal
Nat Immunol 5:678-84 (2004)
DOI:10.1038/ni1082
Reference
PMID:16181333
  Authors
Cresswell P, Ackerman AL, Giodini A, Peaper DR, Wearsch PA.
  Title
Mechanisms of MHC class I-restricted antigen processing and cross-presentation.
  Journal
Immunol Rev 207:145-57 (2005)
DOI:10.1111/j.0105-2896.2005.00316.x
Reference
PMID:15653312
  Authors
Zika E, Ting JP.
  Title
Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes.
  Journal
Curr Opin Immunol 17:58-64 (2005)
DOI:10.1016/j.coi.2004.11.008
Reference
PMID:11244040
  Authors
Reith W, Mach B.
  Title
The bare lymphocyte syndrome and the regulation of MHC expression.
  Journal
Annu Rev Immunol 19:331-73 (2001)
DOI:10.1146/annurev.immunol.19.1.331
Reference
PMID:15745856
  Authors
Lizee G, Basha G, Jefferies WA.
  Title
Tails of wonder: endocytic-sorting motifs key for exogenous antigen presentation.
  Journal
Trends Immunol 26:141-9 (2005)
DOI:10.1016/j.it.2005.01.005
Reference
PMID:15224094
  Authors
Watts C.
  Title
The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules.
  Journal
Nat Immunol 5:685-92 (2004)
DOI:10.1038/ni1088
Reference
PMID:15653315
  Authors
Kaufmann SH, Schaible UE.
  Title
Antigen presentation and recognition in bacterial infections.
  Journal
Curr Opin Immunol 17:79-87 (2005)
DOI:10.1016/j.coi.2004.12.004
Reference
PMID:20010787
  Authors
Groettrup M, Kirk CJ, Basler M
  Title
Proteasomes in immune cells: more than peptide producers?
  Journal
Nat Rev Immunol 10:73-8 (2010)
DOI:10.1038/nri2687
Related
pathway
oor03050  Proteasome
oor04650  Natural killer cell mediated cytotoxicity
oor04660  T cell receptor signaling pathway
KO pathway
ko04612   
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