KEGG   PATHWAY: opi00983
Entry
opi00983                    Pathway                                
Name
Drug metabolism - other enzymes - Ochotona princeps (American pika)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
opi00983  Drug metabolism - other enzymes
opi00983

Organism
Ochotona princeps (American pika) [GN:opi]
Gene
101535921  hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
101523936  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
101526913  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
101517459  inosine-5'-monophosphate dehydrogenase 1-like [KO:K00088] [EC:1.1.1.205]
101522538  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X2 [KO:K00088] [EC:1.1.1.205]
101517275  GMPS; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
101516451  TPMT; thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
101525501  XDH; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
101518626  ITPA; inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
101524234  liver carboxylesterase 1 isoform X1 [KO:K01044] [EC:3.1.1.1]
101524472  liver carboxylesterase 1-like [KO:K01044] [EC:3.1.1.1]
101521389  liver carboxylesterase 1-like [KO:K01044] [EC:3.1.1.1]
101516012  cocaine esterase isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
101516986  cocaine esterase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
101530689  cocaine esterase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
101516256  cocaine esterase-like isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
101518979  UDP-glucuronosyltransferase 1A9-like [KO:K00699] [EC:2.4.1.17]
101533137  UDP-glucuronosyltransferase 1A1 [KO:K00699] [EC:2.4.1.17]
101525627  UDP-glucuronosyltransferase 2A2 isoform X1 [KO:K00699] [EC:2.4.1.17]
101526359  UDP-glucuronosyltransferase 2B14-like isoform X1 [KO:K00699] [EC:2.4.1.17]
101526841  UDP-glucuronosyltransferase 2B14-like isoform X1 [KO:K00699] [EC:2.4.1.17]
101527092  UDP-glucuronosyltransferase 2B14-like isoform X3 [KO:K00699] [EC:2.4.1.17]
101527508  UDP-glucuronosyltransferase 2B16-like isoform X1 [KO:K00699] [EC:2.4.1.17]
101527754  UDP-glucuronosyltransferase 2B17 [KO:K00699] [EC:2.4.1.17]
101528265  UDP-glucuronosyltransferase 2B16-like [KO:K00699] [EC:2.4.1.17]
101528508  UDP-glucuronosyltransferase 2B15 isoform X1 [KO:K00699] [EC:2.4.1.17]
101528743  UDP-glucuronosyltransferase 2B13-like isoform X1 [KO:K00699] [EC:2.4.1.17]
101521271  UDP-glucuronosyltransferase 2B16-like [KO:K00699] [EC:2.4.1.17]
101519225  UDP-glucuronosyltransferase 1A9-like [KO:K00699] [EC:2.4.1.17]
118759004  UDP-glucuronosyltransferase 2B16-like [KO:K00699] [EC:2.4.1.17]
101521755  UDP-glucuronosyltransferase 2B13-like [KO:K00699] [EC:2.4.1.17]
118759009  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
101522272  GUSB; beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
101522236  CDA; cytidine deaminase [KO:K01489] [EC:3.5.4.5]
101527483  thymidine phosphorylase [KO:K00758] [EC:2.4.2.4]
101517804  DPYD; dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
101524614  DPYS; dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
101536114  UPB1; beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
101532122  UPP1; uridine phosphorylase 1 [KO:K00757] [EC:2.4.2.3]
101520788  UPP2; LOW QUALITY PROTEIN: uridine phosphorylase 2 [KO:K00757] [EC:2.4.2.3]
101535953  UCK1; uridine-cytidine kinase 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
101531584  UCKL1; uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
101524964  UCK2; uridine-cytidine kinase 2 [KO:K00876] [EC:2.7.1.48]
101534952  TK2; thymidine kinase 2, mitochondrial isoform X1 [KO:K00857] [EC:2.7.1.21]
101522580  TK1; thymidine kinase, cytosolic isoform X1 [KO:K00857] [EC:2.7.1.21]
101522685  UMPS; uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
101528837  CMPK1; UMP-CMP kinase isoform X1 [KO:K13800] [EC:2.7.4.14]
101524574  RRM1; ribonucleoside-diphosphate reductase large subunit isoform X1 [KO:K10807] [EC:1.17.4.1]
101519755  RRM2; ribonucleoside-diphosphate reductase subunit M2 isoform X2 [KO:K10808] [EC:1.17.4.1]
101524779  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
105941499  nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
101519623  nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
101533930  NME4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
101519960  NME3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
101528481  NME7; nucleoside diphosphate kinase 7 isoform X2 [KO:K00940] [EC:2.7.4.6]
101519425  NME6; nucleoside diphosphate kinase 6 isoform X2 [KO:K00940] [EC:2.7.4.6]
101516399  DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial [KO:K01520] [EC:3.6.1.23]
101519625  MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
101527236  arylamine N-acetyltransferase 2 [KO:K00622] [EC:2.3.1.5]
101523061  arylamine N-acetyltransferase 2-like [KO:K00622] [EC:2.3.1.5]
101532509  cytochrome P450 2E1 isoform X1 [KO:K07415] [EC:1.14.14.-]
101522707  glutathione S-transferase Mu 3 isoform X2 [KO:K00799] [EC:2.5.1.18]
101522940  glutathione S-transferase Mu 2 isoform X2 [KO:K00799] [EC:2.5.1.18]
101523672  glutathione S-transferase Mu 2-like isoform X4 [KO:K00799] [EC:2.5.1.18]
101524307  glutathione S-transferase Mu 1 isoform X3 [KO:K00799] [EC:2.5.1.18]
101532277  glutathione S-transferase Mu 1-like isoform X2 [KO:K00799] [EC:2.5.1.18]
101532518  glutathione S-transferase Mu 1-like isoform X2 [KO:K00799] [EC:2.5.1.18]
101520678  glutathione S-transferase alpha I-like [KO:K00799] [EC:2.5.1.18]
101531637  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
101531866  glutathione S-transferase alpha I [KO:K00799] [EC:2.5.1.18]
101532588  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
101533070  glutathione S-transferase A6-like [KO:K00799] [EC:2.5.1.18]
101531950  glutathione S-transferase Yc-like [KO:K00799] [EC:2.5.1.18]
101531527  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
101531328  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
105941642  glutathione S-transferase Mu 2-like isoform X3 [KO:K00799] [EC:2.5.1.18]
101527080  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
101534648  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
101531952  GSTO1; glutathione S-transferase omega-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
101531717  glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
101516998  MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
101524017  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
101536139  GSTP1; glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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