KEGG   PATHWAY: panu00983
Entry
panu00983                   Pathway                                
Name
Drug metabolism - other enzymes - Papio anubis (olive baboon)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
panu00983  Drug metabolism - other enzymes
panu00983

Organism
Papio anubis (olive baboon) [GN:panu]
Gene
101022686  HPRT1; hypoxanthine-guanine phosphoribosyltransferase isoform X2 [KO:K00760] [EC:2.4.2.8]
101003214  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X2 [KO:K00088] [EC:1.1.1.205]
101016391  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 isoform X4 [KO:K00088] [EC:1.1.1.205]
101007040  GMPS; GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
101018546  TPMT; thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
101025208  XDH; xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
101001216  ITPA; inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
101017969  LOW QUALITY PROTEIN: liver carboxylesterase 1-like [KO:K01044] [EC:3.1.1.1]
101015246  CES1; liver carboxylesterase 1 isoform X2 [KO:K01044] [EC:3.1.1.1]
101004448  CES2; LOW QUALITY PROTEIN: cocaine esterase [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
101017012  UDP-glucuronosyltransferase 2A2 isoform X2 [KO:K00699] [EC:2.4.1.17]
101020325  UGT2A3; UDP-glucuronosyltransferase 2A3 [KO:K00699] [EC:2.4.1.17]
101010645  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1-3 [KO:K00699] [EC:2.4.1.17]
101019271  UDP-glucuronosyltransferase 2B30 isoform X1 [KO:K00699] [EC:2.4.1.17]
100126698  UGT1A4; UDP-glucuronosyltransferase 1-4 precursor [KO:K00699] [EC:2.4.1.17]
100126700  UGT1A5A; UDP glycosyl transferase 1A5A precursor [KO:K00699] [EC:2.4.1.17]
100126701  UGT1A1; UDP-glucuronosyltransferase 1-1 precursor [KO:K00699] [EC:2.4.1.17]
100126702  UGT1A6; UDP-glucuronosyltransferase 1-6 [KO:K00699] [EC:2.4.1.17]
100126703  UGT1A9; UDP-glucuronosyltransferase 1-9 precursor [KO:K00699] [EC:2.4.1.17]
100126705  UGT1A7; UDP-glucuronosyltransferase 1-7 precursor [KO:K00699] [EC:2.4.1.17]
100126761  UGT1A5B; UDP glycosyl transferase 1A5B precursor [KO:K00699] [EC:2.4.1.17]
100126762  UGT1A10B; UDP glycosyl transferase 1A10B precursor [KO:K00699] [EC:2.4.1.17]
100337517  UGT2B39; UDP-glucuronosyltransferase 2B39 precursor [KO:K00699] [EC:2.4.1.17]
100337521  UGT2B42; UDP-glucuronosyltransferase 2B42 precursor [KO:K00699] [EC:2.4.1.17]
100337522  UGT2B15; UDP-glucuronosyltransferase 2B15 precursor [KO:K00699] [EC:2.4.1.17]
100337523  UGT2B44; UDP-glucuronosyltransferase 2B44 precursor [KO:K00699] [EC:2.4.1.17]
100337524  UGT2B45; UDP-glucuronosyltransferase 2B45 precursor [KO:K00699] [EC:2.4.1.17]
101007395  beta-glucuronidase-like isoform X1 [KO:K01195] [EC:3.2.1.31]
101006382  GUSB; beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
101026757  cytochrome P450 3A8 isoform X1 [KO:K17689] [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
101024611  CDA; cytidine deaminase isoform X2 [KO:K01489] [EC:3.5.4.5]
101005875  thymidine phosphorylase isoform X4 [KO:K00758] [EC:2.4.2.4]
100997971  DPYD; dihydropyrimidine dehydrogenase [NADP(+)] isoform X5 [KO:K00207] [EC:1.3.1.2]
101007822  DPYS; dihydropyrimidinase isoform X1 [KO:K01464] [EC:3.5.2.2]
101021904  UPB1; beta-ureidopropionase isoform X1 [KO:K01431] [EC:3.5.1.6]
101020167  UPP1; uridine phosphorylase 1 isoform X1 [KO:K00757] [EC:2.4.2.3]
101008553  UPP2; uridine phosphorylase 2 [KO:K00757] [EC:2.4.2.3]
101018022  UCK2; uridine-cytidine kinase 2 isoform X1 [KO:K00876] [EC:2.7.1.48]
101003007  UCK1; uridine-cytidine kinase 1 [KO:K00876] [EC:2.7.1.48]
101003086  UCKL1; uridine-cytidine kinase-like 1 isoform X10 [KO:K00876] [EC:2.7.1.48]
101004767  TK1; thymidine kinase, cytosolic [KO:K00857] [EC:2.7.1.21]
101025155  TK2; thymidine kinase 2, mitochondrial isoform X1 [KO:K00857] [EC:2.7.1.21]
101020284  UMPS; uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
101016720  CMPK1; UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
101021447  RRM1; ribonucleoside-diphosphate reductase large subunit isoform X1 [KO:K10807] [EC:1.17.4.1]
101026728  RRM2; ribonucleoside-diphosphate reductase subunit M2 isoform X1 [KO:K10808] [EC:1.17.4.1]
101026110  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
101005443  NME7; nucleoside diphosphate kinase 7 isoform X2 [KO:K00940] [EC:2.7.4.6]
103875464  NME1; nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
101014949  NME6; nucleoside diphosphate kinase 6 isoform X1 [KO:K00940] [EC:2.7.4.6]
101016759  nucleoside diphosphate kinase B isoform X1 [KO:K00940] [EC:2.7.4.6]
101024319  NME4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
101018324  NME3; nucleoside diphosphate kinase 3 isoform X2 [KO:K00940] [EC:2.7.4.6]
101013459  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 [KO:K01520] [EC:3.6.1.23]
116275855  DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 [KO:K01520] [EC:3.6.1.23]
101011165  MPO; myeloperoxidase isoform X1 [KO:K10789] [EC:1.11.2.2]
101010131  arylamine N-acetyltransferase 2 isoform X2 [KO:K00622] [EC:2.3.1.5]
101009542  NAT1; arylamine N-acetyltransferase 1 [KO:K00622] [EC:2.3.1.5]
101022006  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
103883727  glutathione S-transferase alpha-4-like [KO:K00799] [EC:2.5.1.18]
101016734  MGST3; microsomal glutathione S-transferase 3 isoform X2 [KO:K00799] [EC:2.5.1.18]
101013512  glutathione S-transferase Mu 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
101012891  GSTM4; glutathione S-transferase Mu 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
101001730  glutathione S-transferase A3 isoform X1 [KO:K00799] [EC:2.5.1.18]
101003128  GSTA4; glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
101009553  GSTO2; glutathione S-transferase omega-2 isoform X1 [KO:K00799] [EC:2.5.1.18]
101001165  MGST2; microsomal glutathione S-transferase 2 isoform X2 [KO:K00799] [EC:2.5.1.18]
101014811  GSTM3; glutathione S-transferase Mu 3 isoform X2 [KO:K00799] [EC:2.5.1.18]
116273173  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
101005127  glutathione S-transferase A5 [KO:K00799] [EC:2.5.1.18]
101008775  GSTO1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
100997115  glutathione S-transferase Mu 5 isoform X2 [KO:K00799] [EC:2.5.1.18]
101015487  glutathione S-transferase theta-2B [KO:K00799] [EC:2.5.1.18]
101016081  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
101015137  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
101016449  glutathione S-transferase theta-4-like isoform X1 [KO:K00799] [EC:2.5.1.18]
101008213  GSTP1; glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
LinkDB

DBGET integrated database retrieval system