KEGG   PATHWAY: panu03040
Entry
panu03040                   Pathway                                
Name
Spliceosome - Papio anubis (olive baboon)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
panu03040  Spliceosome
panu03040

Other DBs
GO: 0005681
Organism
Papio anubis (olive baboon) [GN:panu]
Gene
116272608  U1 spliceosomal RNA [KO:K14276]
116272531  U1 spliceosomal RNA [KO:K14276]
116270916  U1 spliceosomal RNA [KO:K14276]
116276118  U1 spliceosomal RNA [KO:K14276]
116271556  U1 spliceosomal RNA [KO:K14276]
116274278  U1 spliceosomal RNA [KO:K14276]
116271114  U1 spliceosomal RNA [KO:K14276]
116275621  U1 spliceosomal RNA [KO:K14276]
116269942  U1 spliceosomal RNA [KO:K14276]
116275183  U1 spliceosomal RNA [KO:K14276]
116274063  U1 spliceosomal RNA [KO:K14276]
116269096  U1 spliceosomal RNA [KO:K14276]
116275625  U1 spliceosomal RNA [KO:K14276]
116274289  U1 spliceosomal RNA [KO:K14276]
116271858  U1 spliceosomal RNA [KO:K14276]
116272969  U1 spliceosomal RNA [KO:K14276]
116268777  U1 spliceosomal RNA [KO:K14276]
116271397  U1 spliceosomal RNA [KO:K14276]
116274066  U1 spliceosomal RNA [KO:K14276]
116269304  U1 spliceosomal RNA [KO:K14276]
116272296  U1 spliceosomal RNA [KO:K14276]
116271825  U1 spliceosomal RNA [KO:K14276]
116271837  U1 spliceosomal RNA [KO:K14276]
116270635  U1 spliceosomal RNA [KO:K14276]
116275184  U1 spliceosomal RNA [KO:K14276]
116275187  U2 spliceosomal RNA [KO:K14277]
116269945  U2 spliceosomal RNA [KO:K14277]
116269947  U2 spliceosomal RNA [KO:K14277]
116271862  U2 spliceosomal RNA [KO:K14277]
116274073  U2 spliceosomal RNA [KO:K14277]
116270921  U2 spliceosomal RNA [KO:K14277]
116274366  U2 spliceosomal RNA [KO:K14277]
116271169  U2 spliceosomal RNA [KO:K14277]
116269102  U4 spliceosomal RNA [KO:K14278]
116274400  U4 spliceosomal RNA [KO:K14278]
116269105  U4 spliceosomal RNA [KO:K14278]
116269103  U4 spliceosomal RNA [KO:K14278]
116271405  U4 spliceosomal RNA [KO:K14278]
116270474  U4 spliceosomal RNA [KO:K14278]
116268797  U4 spliceosomal RNA [KO:K14278]
116271403  U4 spliceosomal RNA [KO:K14278]
116270198  U4 spliceosomal RNA [KO:K14278]
116275468  U4 spliceosomal RNA [KO:K14278]
116270643  U4 spliceosomal RNA [KO:K14278]
116274851  U4 spliceosomal RNA [KO:K14278]
116271569  U4 spliceosomal RNA [KO:K14278]
116269956  U4 spliceosomal RNA [KO:K14278]
116270473  U4 spliceosomal RNA [KO:K14278]
116271897  U4 spliceosomal RNA [KO:K14278]
116276300  U4 spliceosomal RNA [KO:K14278]
116274850  U4 spliceosomal RNA [KO:K14278]
116269104  U4 spliceosomal RNA [KO:K14278]
116276299  U4 spliceosomal RNA [KO:K14278]
116275645  U4 spliceosomal RNA [KO:K14278]
116270472  U4 spliceosomal RNA [KO:K14278]
116271908  U4 spliceosomal RNA [KO:K14278]
116273879  U4 spliceosomal RNA [KO:K14278]
116275644  U4 spliceosomal RNA [KO:K14278]
116269112  U5 spliceosomal RNA [KO:K14279]
116275971  U5 spliceosomal RNA [KO:K14279]
116271912  U5 spliceosomal RNA [KO:K14279]
116275972  U5 spliceosomal RNA [KO:K14279]
116272322  U5 spliceosomal RNA [KO:K14279]
116275206  U6 spliceosomal RNA [KO:K14280]
116270221  U6 spliceosomal RNA [KO:K14280]
116275480  U6 spliceosomal RNA [KO:K14280]
116269645  U6 spliceosomal RNA [KO:K14280]
116269273  U6 spliceosomal RNA [KO:K14280]
116272325  U6 spliceosomal RNA [KO:K14280]
116274253  U6 spliceosomal RNA [KO:K14280]
116275990  U6 spliceosomal RNA [KO:K14280]
116275469  U6 spliceosomal RNA [KO:K14280]
116269968  U6 spliceosomal RNA [KO:K14280]
116269966  U6 spliceosomal RNA [KO:K14280]
116271408  U6 spliceosomal RNA [KO:K14280]
116273014  U6 spliceosomal RNA [KO:K14280]
116272028  U6 spliceosomal RNA [KO:K14280]
116274292  U6 spliceosomal RNA [KO:K14280]
116272034  U6 spliceosomal RNA [KO:K14280]
116269009  U6 spliceosomal RNA [KO:K14280]
116270939  U6 spliceosomal RNA [KO:K14280]
116273888  U6 spliceosomal RNA [KO:K14280]
116271416  U6 spliceosomal RNA [KO:K14280]
116271092  U6 spliceosomal RNA [KO:K14280]
116273421  U6 spliceosomal RNA [KO:K14280]
116274257  U6 spliceosomal RNA [KO:K14280]
116272179  U6 spliceosomal RNA [KO:K14280]
116269008  U6 spliceosomal RNA [KO:K14280]
116274276  U6 spliceosomal RNA [KO:K14280]
116272812  U6 spliceosomal RNA [KO:K14280]
116274298  U6 spliceosomal RNA [KO:K14280]
116272651  U6 spliceosomal RNA [KO:K14280]
116271574  U6 spliceosomal RNA [KO:K14280]
116271928  U6 spliceosomal RNA [KO:K14280]
116275072  U6 spliceosomal RNA [KO:K14280]
116271589  U6 spliceosomal RNA [KO:K14280]
116275207  U6 spliceosomal RNA [KO:K14280]
116270933  U6 spliceosomal RNA [KO:K14280]
116272327  U6 spliceosomal RNA [KO:K14280]
116269124  U6 spliceosomal RNA [KO:K14280]
116268811  U6 spliceosomal RNA [KO:K14280]
116268804  U6 spliceosomal RNA [KO:K14280]
116273887  U6 spliceosomal RNA [KO:K14280]
116272324  U6 spliceosomal RNA [KO:K14280]
116273890  U6 spliceosomal RNA [KO:K14280]
116268806  U6 spliceosomal RNA [KO:K14280]
116275491  U6 spliceosomal RNA [KO:K14280]
116270483  U6 spliceosomal RNA [KO:K14280]
116273893  U6 spliceosomal RNA [KO:K14280]
116271929  U6 spliceosomal RNA [KO:K14280]
116269971  U6 spliceosomal RNA [KO:K14280]
116271406  U6 spliceosomal RNA [KO:K14280]
116271935  U6 spliceosomal RNA [KO:K14280]
116269114  U6 spliceosomal RNA [KO:K14280]
116269115  U6 spliceosomal RNA [KO:K14280]
116269653  U6 spliceosomal RNA [KO:K14280]
116269366  U6 spliceosomal RNA [KO:K14280]
116274244  U6 spliceosomal RNA [KO:K14280]
116274405  U6 spliceosomal RNA [KO:K14280]
101004675  DDX46; probable ATP-dependent RNA helicase DDX46 isoform X1 [KO:K12811] [EC:5.6.2.7]
100997430  DHX16; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [KO:K12813] [EC:5.6.2.6]
101019164  DHX38; pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 [KO:K12815] [EC:5.6.2.6]
101012103  CDC40; pre-mRNA-processing factor 17 [KO:K12816]
116275379  pre-mRNA-processing factor 17 [KO:K12816]
116275382  pre-mRNA-processing factor 17 [KO:K12816]
100997364  PRPF18; pre-mRNA-splicing factor 18 isoform X2 [KO:K12817]
101025361  DHX8; ATP-dependent RNA helicase DHX8 isoform X1 [KO:K12818] [EC:5.6.2.6]
101000726  SLU7; pre-mRNA-splicing factor SLU7 [KO:K12819]
101007534  DHX15; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 [KO:K12820] [EC:5.6.2.6]
101018242  SNRPB; small nuclear ribonucleoprotein-associated proteins B and B' isoform X1 [KO:K11086]
101001281  SNRPD1; small nuclear ribonucleoprotein Sm D1 [KO:K11087]
101002233  SNRPD2; small nuclear ribonucleoprotein Sm D2 isoform X2 [KO:K11096]
116268927  small nuclear ribonucleoprotein Sm D3 [KO:K11088]
103888267  SNRPD3; small nuclear ribonucleoprotein Sm D3 [KO:K11088]
101021434  SNRPE; small nuclear ribonucleoprotein E [KO:K11097]
100998797  small nuclear ribonucleoprotein E [KO:K11097]
101012297  SNRPF; small nuclear ribonucleoprotein F [KO:K11098]
103876025  small nuclear ribonucleoprotein F-like [KO:K11098]
101023445  SNRPG; small nuclear ribonucleoprotein G isoform X1 [KO:K11099]
101026426  SNRNP70; U1 small nuclear ribonucleoprotein 70 kDa isoform X1 [KO:K11093]
100997801  SNRPA; U1 small nuclear ribonucleoprotein A [KO:K11091]
101012098  SNRPC; U1 small nuclear ribonucleoprotein C isoform X2 [KO:K11095]
101026124  PRPF40B; pre-mRNA-processing factor 40 homolog B isoform X1 [KO:K12821]
101024143  PRPF40A; pre-mRNA-processing factor 40 homolog A isoform X1 [KO:K12821]
100998977  RBM25; RNA-binding protein 25 [KO:K12822]
101004416  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
101019042  TCERG1; transcription elongation regulator 1 isoform X5 [KO:K12824]
100999207  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
101012853  SNRPA1; U2 small nuclear ribonucleoprotein A' [KO:K11092]
101016591  SNRPB2; U2 small nuclear ribonucleoprotein B'' [KO:K11094]
101002392  SF3A1; splicing factor 3A subunit 1 [KO:K12825]
101007780  SF3A2; splicing factor 3A subunit 2 [KO:K12826]
101020963  SF3A3; splicing factor 3A subunit 3 isoform X2 [KO:K12827]
101019207  SF3B1; splicing factor 3B subunit 1 isoform X1 [KO:K12828]
101003210  SF3B2; splicing factor 3B subunit 2 isoform X4 [KO:K12829]
101005727  SF3B3; splicing factor 3B subunit 3 isoform X1 [KO:K12830]
101009249  SF3B4; splicing factor 3B subunit 4 [KO:K12831]
101009289  SF3B5; splicing factor 3B subunit 5 [KO:K12832]
100999622  SF3B6; splicing factor 3B subunit 6 [KO:K12833]
101000185  PHF5A; PHD finger-like domain-containing protein 5A [KO:K12834]
101026169  DDX42; ATP-dependent RNA helicase DDX42 isoform X1 [KO:K12835] [EC:5.6.2.7]
101007045  U2AF1; splicing factor U2AF 35 kDa subunit isoform X1 [KO:K12836]
116271668  U2AF1L4; splicing factor U2AF 26 kDa subunit isoform X1 [KO:K12836]
100999803  U2AF2; splicing factor U2AF 65 kDa subunit isoform X1 [KO:K12837]
101017393  PUF60; poly(U)-binding-splicing factor PUF60 isoform X3 [KO:K12838]
101018359  SMNDC1; survival of motor neuron-related-splicing factor 30 isoform X1 [KO:K12839]
101004933  RBM17; splicing factor 45 [KO:K12840]
101019273  CHERP; calcium homeostasis endoplasmic reticulum protein isoform X2 [KO:K12841]
101013401  U2SURP; U2 snRNP-associated SURP motif-containing protein isoform X1 [KO:K12842]
101017922  retinitis pigmentosa 9 protein [KO:K19604]
101019483  uncharacterized protein LOC101019483 isoform X1 [KO:K19604]
116275018  U6 snRNA-associated Sm-like protein LSm2 [KO:K12621]
101009004  LSM3; U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
101011760  LSM4; U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
101022891  LSM5; U6 snRNA-associated Sm-like protein LSm5 isoform X1 [KO:K12624]
101021249  LSM6; U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
101009184  LSM7; U6 snRNA-associated Sm-like protein LSm7 [KO:K12626]
103883196  LSM8; LSM8 homolog, U6 small nuclear RNA associated [KO:K12627]
101015874  PRPF3; U4/U6 small nuclear ribonucleoprotein Prp3 isoform X1 [KO:K12843]
101023339  PRPF4; U4/U6 small nuclear ribonucleoprotein Prp4 isoform X1 [KO:K12662]
101019345  PPIH; peptidyl-prolyl cis-trans isomerase H isoform X1 [KO:K09567] [EC:5.2.1.8]
100137336  PRPF31; U4/U6 small nuclear ribonucleoprotein Prp31 [KO:K12844]
101005413  SNU13; NHP2-like protein 1 isoform X2 [KO:K12845]
101018258  SNRNP27; U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846]
101021919  USP39; U4/U6.U5 tri-snRNP-associated protein 2 isoform X1 [KO:K12847]
101007153  SART1; U4/U6.U5 tri-snRNP-associated protein 1 isoform X1 [KO:K11984]
101003500  ZMAT2; zinc finger matrin-type protein 2 [KO:K12848]
101007360  PRPF38A; pre-mRNA-splicing factor 38A [KO:K12849]
101026971  PRPF38B; pre-mRNA-splicing factor 38B isoform X1 [KO:K12850]
101016764  EFTUD2; 116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852]
100997513  SNRNP200; U5 small nuclear ribonucleoprotein 200 kDa helicase [KO:K12854] [EC:5.6.2.6]
101001455  PRPF6; pre-mRNA-processing factor 6 isoform X1 [KO:K12855]
101016269  PRPF8; pre-mRNA-processing-splicing factor 8 [KO:K12856]
101023432  SNRNP40; U5 small nuclear ribonucleoprotein 40 kDa protein isoform X1 [KO:K12857]
101010400  DDX23; probable ATP-dependent RNA helicase DDX23 [KO:K12858] [EC:5.6.2.7]
101000478  TXNL4A; thioredoxin-like protein 4A isoform X1 [KO:K12859]
116270598  thioredoxin-like protein 4A [KO:K12859]
101007031  PRPF19; pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
101005001  CDC5L; cell division cycle 5-like protein [KO:K12860]
101023673  BCAS2; pre-mRNA-splicing factor SPF27 isoform X2 [KO:K12861]
101016660  PLRG1; pleiotropic regulator 1 [KO:K12862]
101011720  CWC15; spliceosome-associated protein CWC15 homolog [KO:K12863]
101022128  CTNNBL1; beta-catenin-like protein 1 isoform X1 [KO:K12864]
101009582  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
101024987  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
101011433  PQBP1; polyglutamine-binding protein 1 isoform X2 [KO:K12865]
101014446  WBP11; WW domain-binding protein 11 [KO:K12866]
101010245  SNW1; SNW domain-containing protein 1 isoform X2 [KO:K06063]
101016549  XAB2; LOW QUALITY PROTEIN: pre-mRNA-splicing factor SYF1 [KO:K12867]
101000194  SYF2; pre-mRNA-splicing factor SYF2 isoform X1 [KO:K12868]
101005409  CRNKL1; crooked neck-like protein 1 isoform X1 [KO:K12869]
101023553  ISY1; pre-mRNA-splicing factor ISY1 homolog isoform X1 [KO:K12870]
101003828  PPIL1; peptidyl-prolyl cis-trans isomerase-like 1 [KO:K12733] [EC:5.2.1.8]
100999966  PPIE; peptidyl-prolyl cis-trans isomerase E isoform X1 [KO:K09564] [EC:5.2.1.8]
100997295  CCDC12; coiled-coil domain-containing protein 12 isoform X2 [KO:K12871]
101017366  RBM22; pre-mRNA-splicing factor RBM22 [KO:K12872]
101020654  BUD31; protein BUD31 homolog [KO:K12873]
101022459  AQR; RNA helicase aquarius isoform X1 [KO:K12874]
100999586  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
101017699  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
101016843  MAGOH; protein mago nashi homolog [KO:K12877]
101013002  MAGOHB; protein mago nashi homolog 2 isoform X1 [KO:K12877]
101026300  THOC1; THO complex subunit 1 [KO:K12878]
101021758  THOC2; THO complex subunit 2 isoform X1 [KO:K12879]
101013084  THOC3; THO complex subunit 3 [KO:K12880]
101006738  ALYREF; THO complex subunit 4 [KO:K12881]
101023691  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
101019375  NCBP2; nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883]
108583765  NCBP2L; nuclear cap-binding protein subunit 2-like [KO:K12883]
101002653  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
101021791  HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 isoform X1 [KO:K12741]
100999250  HNRNPA1; heterogeneous nuclear ribonucleoprotein A1 [KO:K12741]
100997297  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
100999585  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
101026533  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
101007636  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
101012801  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
101004652  HNRNPA1L2; LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like 2 [KO:K12741]
110742258  heterogeneous nuclear ribonucleoprotein A1-like isoform X1 [KO:K12741]
116274471  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
116275459  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
116276419  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
101017281  heterogeneous nuclear ribonucleoprotein A3-like isoform X1 [KO:K12741]
116270599  heterogeneous nuclear ribonucleoprotein A3-like [KO:K12741]
100998683  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein C [KO:K12884]
101023879  HNRNPC; heterogeneous nuclear ribonucleoproteins C1/C2 isoform X3 [KO:K12884]
100998645  heterogeneous nuclear ribonucleoprotein C-like 1 [KO:K12884]
100999733  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein C-like 2 [KO:K12884]
101018759  RNA-binding motif protein, X chromosome-like [KO:K12885]
101011666  RBMX; RNA-binding motif protein, X chromosome isoform X1 [KO:K12885]
101006841  HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
101025965  HNRNPM; heterogeneous nuclear ribonucleoprotein M isoform X2 [KO:K12887]
101018749  HNRNPU; heterogeneous nuclear ribonucleoprotein U [KO:K12888]
101019920  PCBP1; poly(rC)-binding protein 1 [KO:K12889]
101006938  SRSF1; serine/arginine-rich splicing factor 1 isoform X1 [KO:K12890]
101013289  SRSF8; serine/arginine-rich splicing factor 8 [KO:K12891]
101014714  serine/arginine-rich splicing factor 8-like [KO:K12891]
101026413  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
100998251  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
101016476  SRSF4; serine/arginine-rich splicing factor 4 isoform X1 [KO:K12893]
101012724  SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
101006220  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
101019216  SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
101007956  SRSF9; serine/arginine-rich splicing factor 9 [KO:K21123]
101022528  TRA2B; transformer-2 protein homolog beta isoform X1 [KO:K12897]
100137351  TRA2A; transformer-2 protein homolog alpha [KO:K12897]
101020126  SRSF10; serine/arginine-rich splicing factor 10 isoform X1 [KO:K12900]
110741057  serine/arginine-rich splicing factor 10 [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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