KEGG   PATHWAY: peu03440
Entry
peu03440                    Pathway                                
Name
Homologous recombination - Populus euphratica (Euphrates poplar)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
peu03440  Homologous recombination
peu03440

Other DBs
GO: 0000724
Organism
Populus euphratica (Euphrates poplar) [GN:peu]
Gene
105114186  single-stranded DNA-binding protein, mitochondrial [KO:K03111]
105111144  DNA repair protein recA homolog 3, mitochondrial-like isoform X1 [KO:K03553]
105111260  DNA repair protein recA homolog 1, chloroplastic [KO:K03553]
105114869  DNA repair protein recA homolog 3, mitochondrial-like isoform X1 [KO:K03553]
105114444  DNA polymerase I A, chloroplastic/mitochondrial-like [KO:K02335] [EC:2.7.7.7]
105130152  DNA polymerase I A, chloroplastic/mitochondrial-like [KO:K02335] [EC:2.7.7.7]
105135468  uncharacterized protein LOC105135468 isoform X1 [KO:K03655] [EC:5.6.2.4]
105110325  DNA repair protein RAD50 [KO:K10866] [EC:3.6.-.-]
105139687  double-strand break repair protein MRE11 isoform X1 [KO:K10865]
105142710  nijmegen breakage syndrome 1 protein [KO:K10867]
105128541  serine/threonine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
105141262  protein BREAST CANCER SUSCEPTIBILITY 1 homolog [KO:K10683]
105125619  protein BREAST CANCER SUSCEPTIBILITY 1 homolog [KO:K10683]
105132840  Fanconi anemia group J protein homolog isoform X1 [KO:K15362] [EC:5.6.2.3]
105137413  BRCT domain-containing protein At4g02110-like [KO:K10728]
105109415  DNA topoisomerase 2-binding protein 1 isoform X1 [KO:K10728]
105137966  BRCT domain-containing protein At4g02110-like isoform X1 [KO:K10728]
105119625  uncharacterized protein LOC105119625 [KO:K20776]
105128868  BRCA1-A complex subunit BRE-like isoform X1 [KO:K12173]
105140092  BRCA1-A complex subunit BRE-like isoform X1 [KO:K12173]
105133390  lys-63-specific deubiquitinase BRCC36-like [KO:K11864] [EC:3.4.19.-]
105118053  protein BREAST CANCER SUSCEPTIBILITY 2 homolog B-like [KO:K08775]
105125913  protein BREAST CANCER SUSCEPTIBILITY 2 homolog B-like [KO:K08775]
105114747  probable 26S proteasome complex subunit sem1-1 [KO:K10881]
105114663  replication protein A 70 kDa DNA-binding subunit A-like [KO:K07466]
105128185  replication protein A 70 kDa DNA-binding subunit E-like [KO:K07466]
105112548  replication protein A 70 kDa DNA-binding subunit B [KO:K07466]
105139278  replication protein A 32 kDa subunit B-like isoform X1 [KO:K10739]
105114815  replication protein A 32 kDa subunit B-like [KO:K10739]
105109342  replication protein A 32 kDa subunit A-like [KO:K10739]
105130497  replication protein A 32 kDa subunit A-like [KO:K10739]
105110766  replication protein A 14 kDa subunit A-like [KO:K10740]
105125445  replication protein A 14 kDa subunit B-like [KO:K10740]
105136310  LOW QUALITY PROTEIN: DNA repair protein RAD51 homolog [KO:K04482]
105132345  DNA repair protein RAD51 homolog 3 isoform X1 [KO:K10870]
105119914  DNA repair protein RAD51 homolog 3-like isoform X1 [KO:K10870]
105139286  DNA repair protein XRCC3 homolog [KO:K10880]
105134453  SNF2 domain-containing protein CLASSY 3-like [KO:K10875] [EC:5.6.2.-]
105142041  SNF2 domain-containing protein CLASSY 3 [KO:K10875] [EC:5.6.2.-]
105134667  SNF2 domain-containing protein CLASSY 3-like isoform X1 [KO:K10875] [EC:5.6.2.-]
105131257  SNF2 domain-containing protein CLASSY 3-like [KO:K10875] [EC:5.6.2.-]
105110267  SNF2 domain-containing protein CLASSY 1-like isoform X1 [KO:K10875] [EC:5.6.2.-]
105112473  protein CHROMATIN REMODELING 25 [KO:K10875] [EC:5.6.2.-]
105130373  DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
105131769  DNA polymerase delta small subunit-like isoform X1 [KO:K02328]
105111224  DNA polymerase delta small subunit-like isoform X1 [KO:K02328]
105117328  DNA polymerase delta small subunit-like isoform X1 [KO:K02328]
105109677  uncharacterized protein LOC105109677 isoform X1 [KO:K03504]
105119334  DNA polymerase delta subunit 4 [KO:K03505]
105139617  DNA polymerase delta subunit 4-like [KO:K03505]
105114528  ATP-dependent DNA helicase Q-like 4A [KO:K10901] [EC:5.6.2.4]
105124080  ATP-dependent DNA helicase Q-like 3 isoform X1 [KO:K10901] [EC:5.6.2.4]
105130366  DNA topoisomerase 3-alpha isoform X1 [KO:K03165] [EC:5.6.2.1]
105115983  DNA topoisomerase 3-alpha-like isoform X1 [KO:K03165] [EC:5.6.2.1]
105107691  DNA topoisomerase 3-beta isoform X1 [KO:K03165] [EC:5.6.2.1]
105137900  crossover junction endonuclease MUS81 isoform X1 [KO:K08991] [EC:3.1.22.-]
105126402  crossover junction endonuclease EME1B-like isoform X1 [KO:K10882] [EC:3.1.22.-]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   
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