KEGG   PATHWAY: peu04148
Entry
peu04148                    Pathway                                
Name
Efferocytosis - Populus euphratica (Euphrates poplar)
Class
Cellular Processes; Transport and catabolism
Pathway map
peu04148  Efferocytosis
peu04148

Organism
Populus euphratica (Euphrates poplar) [GN:peu]
Gene
105138778  sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
105114862  mitogen-activated protein kinase kinase 6 [KO:K04368] [EC:2.7.12.2]
105134211  uncharacterized protein LOC105134211 isoform X1 [KO:K17398] [EC:2.1.1.37]
105107602  calcium-transporting ATPase 3, endoplasmic reticulum-type [KO:K05853] [EC:7.2.2.10]
105110215  protein-tyrosine-phosphatase IBR5-like isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105131594  phospholipid-transporting ATPase 1-like [KO:K14802] [EC:7.6.2.1]
105131596  phospholipid-transporting ATPase 1-like isoform X1 [KO:K14802] [EC:7.6.2.1]
105108888  phospholipid-transporting ATPase 1-like [KO:K14802] [EC:7.6.2.1]
105113568  phospholipid-transporting ATPase 3-like isoform X1 [KO:K14802] [EC:7.6.2.1]
105132378  phospholipid-transporting ATPase 3 [KO:K14802] [EC:7.6.2.1]
105141072  phospholipid-transporting ATPase 1-like [KO:K14802] [EC:7.6.2.1]
105118018  ALA-interacting subunit 3-like [KO:K26935]
105117743  putative ALA-interacting subunit 2 [KO:K26935]
105135239  ALA-interacting subunit 3-like [KO:K26935]
105118012  ALA-interacting subunit 3-like [KO:K26935]
105142440  rac-like GTP-binding protein ARAC7 [KO:K04392]
105109619  rac-like GTP-binding protein RAC2 [KO:K04392]
105139559  rac-like GTP-binding protein ARAC8 [KO:K04392]
105140663  rac-like GTP-binding protein RAC13 [KO:K04392]
105128576  rac-like GTP-binding protein ARAC8 [KO:K04392]
105131370  rac-like GTP-binding protein RAC2 [KO:K04392]
105134644  rac-like GTP-binding protein RAC2 [KO:K04392]
105132941  rac-like GTP-binding protein ARAC5 [KO:K04392]
105138694  rac-like GTP-binding protein RHO1 [KO:K04392]
105141222  rac-like GTP-binding protein 5 [KO:K04392]
105116783  rac-like GTP-binding protein RHO1 isoform X1 [KO:K04392]
105119177  rac-like GTP-binding protein 3 [KO:K04392]
105140903  rac-like GTP-binding protein 5 [KO:K04392]
105109887  rac-like GTP-binding protein ARAC1 [KO:K04392]
105134424  calreticulin-3-like [KO:K08057]
105116058  calreticulin-3-like [KO:K08057]
105113086  calreticulin-3-like [KO:K08057]
105125151  calreticulin isoform X1 [KO:K08057]
105134292  calreticulin-like [KO:K08057]
105113578  calreticulin-3-like [KO:K08057]
105108846  ras-related protein RHN1-like [KO:K07889]
105116122  LOW QUALITY PROTEIN: transforming growth factor-beta receptor-associated protein 1 homolog [KO:K20177]
105124186  transforming growth factor-beta receptor-associated protein 1-like [KO:K20177]
105127408  LOW QUALITY PROTEIN: transforming growth factor-beta receptor-associated protein 1 homolog [KO:K20177]
105135898  vacuolar protein sorting-associated protein 8 homolog isoform X1 [KO:K20178]
105111668  vacuolar protein-sorting-associated protein 11 homolog [KO:K20179]
105126905  protein VACUOLELESS1-like isoform X1 [KO:K20180]
105139848  protein VACUOLELESS1-like [KO:K20180]
105140400  vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
105142504  vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
105130731  vacuolar protein-sorting-associated protein 33 homolog [KO:K20182]
105137135  vacuolar protein-sorting-associated protein 33 homolog isoform X1 [KO:K20182]
105125565  vacuolar protein-sorting-associated protein 33 homolog [KO:K20182]
105126577  vam6/Vps39-like protein [KO:K20183]
105110401  vam6/Vps39-like protein [KO:K20183]
105111538  vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
105111681  vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
105139893  ras-related protein Rab7-like [KO:K07897]
105126950  ras-related protein Rab7 [KO:K07897]
105134724  ras-related protein Rab7 [KO:K07897]
105142643  ras-related protein Rab7-like [KO:K07897]
105108838  ras-related protein Rab7 [KO:K07897]
105115082  ras-related protein Rab7-like [KO:K07897]
105123881  ras-related protein Rab7-like [KO:K07897]
105126518  lysosomal amino acid transporter 1 isoform X1 [KO:K23678]
105136860  lysosomal amino acid transporter 1 [KO:K23678]
105115030  uncharacterized protein LOC105115030 [KO:K23678]
105137299  uncharacterized protein LOC105137299 [KO:K23678]
105132324  arginase 1, mitochondrial-like [KO:K01476] [EC:3.5.3.1]
105120796  arginase 1, mitochondrial [KO:K01476] [EC:3.5.3.1]
105132905  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
105109925  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
105133776  cytochrome b-c1 complex subunit Rieske-4, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
105123103  cytochrome b-c1 complex subunit Rieske-4, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
105108545  triacylglycerol lipase 1 [KO:K01052] [EC:3.1.1.13]
105113315  triacylglycerol lipase 2-like [KO:K01052] [EC:3.1.1.13]
105113316  triacylglycerol lipase 2-like [KO:K01052] [EC:3.1.1.13]
105113318  triacylglycerol lipase 2-like [KO:K01052] [EC:3.1.1.13]
105110561  triacylglycerol lipase 2 [KO:K01052] [EC:3.1.1.13]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
peu00010  Glycolysis / Gluconeogenesis
peu04145  Phagosome
KO pathway
ko04148   
LinkDB

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