KEGG   PATHWAY: pfs00310
Entry
pfs00310                    Pathway                                
Name
Lysine degradation - Pseudomonas fluorescens SBW25
Class
Metabolism; Amino acid metabolism
Pathway map
pfs00310  Lysine degradation
pfs00310

Module
pfs_M00957  Lysine degradation, bacteria, L-lysine => glutarate => succinate/acetyl-CoA [PATH:pfs00310]
Other DBs
GO: 0006554
Organism
Pseudomonas fluorescens SBW25 [GN:pfs]
Gene
PFLU_0549  Aldehyde dehydrogenase (NAD(+)) (EC [KO:K26061]
PFLU_5130  Putative 4-aminobutyrate aminotransferase [KO:K26062] [EC:2.6.1.39]
PFLU_1821  sucB; Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (EC (2-oxoglutarate dehydrogenase complex component E2) [KO:K00658] [EC:2.3.1.61]
PFLU_1822  lpd; Dihydrolipoyl dehydrogenase (EC [KO:K00382] [EC:1.8.1.4]
PFLU_3967  Dihydrolipoyl dehydrogenase (EC [KO:K00382] [EC:1.8.1.4]
PFLU_0115  Putative acyl-CoA dehydrogenase [KO:K00252] [EC:1.3.8.6]
PFLU_3030  Putative phenylacetic acid degradation enoyl-CoA hydratase (EC [KO:K01692] [EC:4.2.1.17]
PFLU_1553  fadB; Fatty acid oxidation complex subunit alpha [Includes: Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase (EC (EC (EC; 3-hydroxyacyl-CoA dehydrogenase (EC ] [KO:K01825] [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8]
PFLU_4661  Putative fatty acid oxidative multifunctional enzyme [KO:K01782] [EC:1.1.1.35 4.2.1.17 5.1.2.3]
PFLU_3028  Putative acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
PFLU_3297  Putative acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
PFLU_3526  Putative 3-ketoacyl-CoA thiolase (EC [KO:K00626] [EC:2.3.1.9]
PFLU_0655  Putative thiolase [KO:K00626] [EC:2.3.1.9]
PFLU_4662  Putative acetyl CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
PFLU_2150  Putative acetyl-CoA transferase [KO:K00626] [EC:2.3.1.9]
PFLU_5656  Putative oxidase [KO:K00468] [EC:1.13.12.2]
PFLU_5595  Putative oxidoreductase [KO:K00468] [EC:1.13.12.2]
PFLU_5596  Putative hydrolase [KO:K01506] [EC:3.5.1.30]
PFLU_3010  Putative aspartate racemase [KO:K25316] [EC:5.1.1.10]
PFLU_1209  Putative betaine aldehyde dehydrogenase [KO:K00137] [EC:1.2.1.19]
PFLU_1214  Putative aldehyde dehydrogenase [KO:K00137] [EC:1.2.1.19]
PFLU_0181  gabT; 4-aminobutyrate aminotransferase (EC [KO:K14268] [EC:2.6.1.48 2.6.1.19]
PFLU_4036  Putative 4-aminobutyrate aminotransferase [KO:K07250] [EC:2.6.1.19 2.6.1.22 2.6.1.48]
PFLU_1128  Putative aminotransferase [KO:K07250] [EC:2.6.1.19 2.6.1.22 2.6.1.48]
PFLU_4039  Putative succinate-semialdehyde dehydrogenase [NADP+] [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
PFLU_1938  gabD2; Succinate-semialdehyde dehydrogenase (EC [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
PFLU_0180  gabD; Succinate-semialdehyde dehydrogenase [NADP+] (EC [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
PFLU_3597  DUF1338 domain-containing protein [KO:K25986] [EC:1.13.11.93]
PFLU_0116  Putative CoA-transferase [KO:K01041] [EC:2.8.3.-]
PFLU_2704  Putative dehydrogenase [KO:K13609] [EC:1.5.1.21]
PFLU_0550  Putative oxidoreductase [KO:K26065]
PFLU_4112  Putative aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
PFLU_4056  Putative betaine aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
PFLU_4654  Putative gamma-butyrobetaine dioxygenase [KO:K00471] [EC:1.14.11.1]
Compound
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00037  Glycine
C00042  Succinate
C00047  L-Lysine
C00068  Thiamin diphosphate
C00136  Butanoyl-CoA
C00164  Acetoacetate
C00322  2-Oxoadipate
C00332  Acetoacetyl-CoA
C00408  L-Pipecolate
C00431  5-Aminopentanoate
C00449  N6-(L-1,3-Dicarboxypropyl)-L-lysine
C00450  (S)-2,3,4,5-Tetrahydropyridine-2-carboxylate
C00487  Carnitine
C00489  Glutarate
C00527  Glutaryl-CoA
C00739  D-Lysine
C00877  Crotonoyl-CoA
C00956  L-2-Aminoadipate
C00990  5-Aminopentanamide
C01087  (R)-2-Hydroxyglutarate
C01142  (3S)-3,6-Diaminohexanoate
C01144  (S)-3-Hydroxybutanoyl-CoA
C01149  4-Trimethylammoniobutanal
C01181  4-Trimethylammoniobutanoate
C01186  (3S,5S)-3,5-Diaminohexanoate
C01211  Procollagen 5-hydroxy-L-lysine
C01259  (3S)-3-Hydroxy-N6,N6,N6-trimethyl-L-lysine
C01672  Cadaverine
C02188  Protein lysine
C02727  N6-Acetyl-L-lysine
C03087  5-Acetamidopentanoate
C03196  (S)-2-Hydroxyglutarate
C03239  6-Amino-2-oxohexanoate
C03273  5-Oxopentanoate
C03366  5-Phosphooxy-L-lysine
C03656  (S)-5-Amino-3-oxohexanoic acid
C03793  N6,N6,N6-Trimethyl-L-lysine
C04020  D-Lysopine
C04076  L-2-Aminoadipate 6-semialdehyde
C04092  Delta1-Piperideine-2-carboxylate
C04487  5-(D-Galactosyloxy)-L-lysine-procollagen
C05161  (2R,5S)-2,5-Diaminohexanoate
C05231  L-3-Aminobutyryl-CoA
C05544  Protein N6-methyl-L-lysine
C05545  Protein N6,N6-dimethyl-L-lysine
C05546  Protein N6,N6,N6-trimethyl-L-lysine
C05548  6-Acetamido-2-oxohexanoate
C05825  2-Amino-5-oxohexanoate
C06157  [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine
C12455  5-Aminopentanal
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16741  L-Hydroxylysine
C22667  4-Carboxy-1-hydroxybutyryl-ThPP
Reference
PMID:11802770
  Authors
Vaz FM, Wanders RJ.
  Title
Carnitine biosynthesis in mammals.
  Journal
Biochem J 361:417-29 (2002)
DOI:10.1042/bj3610417
Reference
PMID:1682209
  Authors
Large PJ, Robertson A.
  Title
The route of lysine breakdown in Candida tropicalis.
  Journal
FEMS Microbiol Lett 66:209-13 (1991)
DOI:10.1111/j.1574-6968.1990.tb03998.x
Related
pathway
pfs00020  Citrate cycle (TCA cycle)
pfs00300  Lysine biosynthesis
pfs00780  Biotin metabolism
KO pathway
ko00310   
LinkDB

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