KEGG   PATHWAY: pkl04814
Entry
pkl04814                    Pathway                                
Name
Motor proteins - Pipistrellus kuhlii (Kuhl's pipistrelle)
Class
Cellular Processes; Cell motility
Pathway map
pkl04814  Motor proteins
pkl04814

Organism
Pipistrellus kuhlii (Kuhl's pipistrelle) [GN:pkl]
Gene
118704248  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
118712802  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
118714273  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
118709647  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
118720989  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
118715439  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 isoform X1 [KO:K10416]
118717296  DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 isoform X1 [KO:K10417]
118728075  DYNLL2; dynein light chain 2, cytoplasmic [KO:K10418]
118729519  LOW QUALITY PROTEIN: dynein light chain 1, cytoplasmic-like [KO:K10418]
118731176  dynein light chain 1, cytoplasmic-like [KO:K10418]
118725531  DYNLL1; dynein light chain 1, cytoplasmic [KO:K10418]
118720731  DYNLRB2; dynein light chain roadblock-type 2 [KO:K10419]
118703263  dynein light chain roadblock-type 1 [KO:K10419]
118705167  DYNLT1; dynein light chain Tctex-type 1 isoform X1 [KO:K10420]
118726358  dynein light chain Tctex-type 1-like [KO:K10420]
118702362  DYNLT3; dynein light chain Tctex-type 3 [KO:K10420]
118712092  DYNLT2; tctex1 domain-containing protein 3 isoform X1 [KO:K25419]
118723734  DYNLT4; tctex1 domain-containing protein 4 [KO:K25420]
118722856  DYNLT5; tctex1 domain-containing protein 1 [KO:K25421]
118703538  DNAH5; dynein heavy chain 5, axonemal isoform X1 [KO:K10408]
118727592  DNAH14; dynein heavy chain 14, axonemal [KO:K10408]
118704581  DNAH17; dynein heavy chain 17, axonemal [KO:K10408]
118705872  DNAH8; dynein heavy chain 8, axonemal [KO:K10408]
118714571  DNAH11; dynein heavy chain 11, axonemal [KO:K10408]
118715093  DNAH12; dynein heavy chain 12, axonemal [KO:K10408]
118715161  DNAH1; dynein heavy chain 1, axonemal [KO:K10408]
118731486  DNAH3; LOW QUALITY PROTEIN: dynein heavy chain 3, axonemal [KO:K10408]
118709815  DNAH7; dynein heavy chain 7, axonemal [KO:K10408]
118717599  DNAH6; dynein heavy chain 6, axonemal [KO:K10408]
118710450  DNAH10; dynein heavy chain 10, axonemal [KO:K10408]
118726780  DNAH9; dynein heavy chain 9, axonemal [KO:K10408]
118726845  DNAH2; dynein heavy chain 2, axonemal isoform X1 [KO:K10408]
118716390  DNAI1; dynein intermediate chain 1, axonemal [KO:K10409]
118732259  DNAI2; dynein intermediate chain 2, axonemal [KO:K11143]
118722810  DNAI3; WD repeat-containing protein 63 [KO:K24722]
118724146  DNAI4; LOW QUALITY PROTEIN: WD repeat-containing protein 78 [KO:K24723]
118724280  DNALI1; axonemal dynein light intermediate polypeptide 1 isoform X1 [KO:K10410]
118715530  DNAL1; dynein light chain 1, axonemal [KO:K10411]
118729862  DNAL4; dynein light chain 4, axonemal [KO:K10412]
118717554  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
118730270  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
118716387  DCTN3; dynactin subunit 3 [KO:K10425]
118711505  DCTN4; dynactin subunit 4 isoform X1 [KO:K10426]
118731595  DCTN5; dynactin subunit 5 [KO:K10427]
118730362  DCTN6; dynactin subunit 6 isoform X1 [KO:K10428]
118727929  ACTR1B; beta-centractin isoform X1 [KO:K16575]
118718917  ACTR1A; alpha-centractin isoform X1 [KO:K16575]
118717384  ACTR10; actin-related protein 10 [KO:K16576]
118711742  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
118730596  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
118727119  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
118724893  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
118725403  BICDL1; BICD family-like cargo adapter 1 isoform X1 [KO:K16756]
118703162  BICDL2; BICD family-like cargo adapter 2 isoform X1 [KO:K16756]
118729219  HOOK3; protein Hook homolog 3 isoform X1 [KO:K16536]
118728759  TUBA1B; tubulin alpha-1B chain [KO:K07374]
118728760  TUBA1A; tubulin alpha-1A chain [KO:K07374]
118728863  tubulin alpha-1C chain [KO:K07374]
118729376  tubulin alpha-4 chain isoform X1 [KO:K07374]
118714290  tubulin alpha-1C chain-like [KO:K07374]
118731844  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
118709593  tubulin alpha-1D chain-like [KO:K07374]
118725584  LOW QUALITY PROTEIN: tubulin alpha-3 chain-like [KO:K07374]
118725585  tubulin alpha-3 chain-like [KO:K07374]
118702746  tubulin alpha-1C chain-like [KO:K07374]
118714072  TUBB; tubulin beta chain [KO:K07375]
118707037  TUBB4B; LOW QUALITY PROTEIN: tubulin beta-4B chain [KO:K07375]
118731426  TUBB4A; tubulin beta-4A chain isoform X1 [KO:K07375]
118707326  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
118723429  tubulin beta-2B chain [KO:K07375]
118724463  tubulin beta-2B chain isoform X1 [KO:K07375]
118708731  TUBB1; tubulin beta-1 chain [KO:K07375]
118710118  tubulin beta-3 chain [KO:K07375]
118726263  tubulin gamma-1 chain isoform X1 [KO:K10389]
118726265  TUBG2; tubulin gamma-2 chain isoform X1 [KO:K10389]
118726542  TUBD1; tubulin delta chain isoform X1 [KO:K10390]
118705846  TUBE1; tubulin epsilon chain [KO:K10391]
118727799  KIF5B; kinesin-1 heavy chain [KO:K10396]
118730259  KIF5A; kinesin heavy chain [KO:K10396]
118709288  KIF5C; kinesin heavy chain [KO:K10396]
118705242  KLC4; kinesin light chain 4 [KO:K10407]
118706825  KLC3; kinesin light chain 3 isoform X1 [KO:K10407]
118706876  KLC2; kinesin light chain 2 isoform X1 [KO:K10407]
118715874  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
118711585  KIF3A; kinesin-like protein KIF3A isoform X1 [KO:K10394]
118707922  KIF3B; kinesin-like protein KIF3B [KO:K20196]
118721690  KIFAP3; kinesin-associated protein 3 isoform X1 [KO:K25388]
118717223  KIF3C; kinesin-like protein KIF3C isoform X1 [KO:K20197]
118722389  KIF17; kinesin-like protein KIF17 isoform X1 [KO:K20198]
118732042  KIF1B; kinesin-like protein KIF1B isoform X1 [KO:K10392]
118709977  KIF1A; kinesin-like protein KIF1A isoform X1 [KO:K10392]
118726999  KIF1C; kinesin-like protein KIF1C isoform X1 [KO:K10392]
118724612  KIF13A; kinesin-like protein KIF13A isoform X1 [KO:K17914]
118710817  KIF13B; kinesin-like protein KIF13B isoform X1 [KO:K17914]
118720352  KIF14; kinesin-like protein KIF14 [KO:K17915]
118707490  KIF16B; kinesin-like protein KIF16B isoform X1 [KO:K17916]
118722791  STARD9; stAR-related lipid transfer protein 9 isoform X1 [KO:K16491]
118704117  KIF4A; chromosome-associated kinesin KIF4A isoform X1 [KO:K10395]
118705709  chromosome-associated kinesin KIF4A-like [KO:K10395]
118706340  KIF7; LOW QUALITY PROTEIN: kinesin-like protein KIF7 [KO:K18806]
118721889  KIF21B; kinesin-like protein KIF21B [KO:K24185]
118730884  KIF21A; kinesin-like protein KIF21A isoform X1 [KO:K24185]
118716442  KIF27; kinesin-like protein KIF27 isoform X1 [KO:K24186]
118719292  KIF11; kinesin-like protein KIF11 isoform X1 [KO:K10398]
118719277  KIF20B; kinesin-like protein KIF20B isoform X1 [KO:K10402]
118710704  KIF20A; kinesin-like protein KIF20A [KO:K10402]
118718672  KIF23; kinesin-like protein KIF23 isoform X1 [KO:K17387]
118703299  CENPE; centromere-associated protein E isoform X1 [KO:K11498]
118713186  KIF18A; kinesin-like protein KIF18A [KO:K10401]
118726464  KIF18B; kinesin-like protein KIF18B [KO:K26156]
118702072  KIF19; kinesin-like protein KIF19 isoform X1 [KO:K26157]
118706134  KIF6; kinesin-like protein KIF6 [KO:K10397]
118714789  KIF9; kinesin-like protein KIF9 [KO:K10397]
118704846  kinesin-like protein KIF22 [KO:K10403]
118704869  kinesin-like protein KIF22 [KO:K10403]
118727601  KIF26B; kinesin-like protein KIF26B [KO:K10404]
118715868  KIF26A; kinesin-like protein KIF26A [KO:K10404]
118704386  KIF12; kinesin-like protein KIF12 [KO:K10399]
118715562  KIF15; kinesin-like protein KIF15 [KO:K10400]
118728062  KIF2B; kinesin-like protein KIF2B [KO:K10393]
118723636  KIF2C; kinesin-like protein KIF2C isoform X1 [KO:K10393]
118716392  KIF24; kinesin-like protein KIF24 isoform X1 [KO:K10393]
118702756  KIF2A; kinesin-like protein KIF2A isoform X1 [KO:K10393]
118705653  KIFC1; kinesin-like protein KIFC1 isoform X1 [KO:K10405]
118720409  KIFC3; kinesin-like protein KIFC3 isoform X1 [KO:K10406]
118710142  KIFC2; kinesin-like protein KIFC2 isoform X1 [KO:K10406]
118712099  KIF25; LOW QUALITY PROTEIN: kinesin-like protein KIF25 [KO:K18627]
118720333  MYO1G; unconventional myosin-Ig [KO:K10356]
118728057  MYO1D; unconventional myosin-Id isoform X1 [KO:K10356]
118720401  MYO1E; unconventional myosin-Ie isoform X1 [KO:K10356]
118729233  MYO1A; unconventional myosin-Ia isoform X1 [KO:K10356]
118709481  MYO1B; unconventional myosin-Ib isoform X1 [KO:K10356]
118725718  MYO1H; unconventional myosin-Ih [KO:K10356]
118725826  MYO1F; unconventional myosin-If isoform X1 [KO:K10356]
118702577  MYO1C; unconventional myosin-Ic isoform X1 [KO:K10356]
118731564  MYO3A; myosin-IIIa [KO:K08834] [EC:2.7.11.1]
118709811  MYO3B; myosin-IIIb isoform X1 [KO:K08834] [EC:2.7.11.1]
118721056  MYO5A; unconventional myosin-Va isoform X1 [KO:K10357]
118721107  MYO5C; unconventional myosin-Vc [KO:K10357]
118708027  MYO5B; unconventional myosin-Vb isoform X1 [KO:K10357]
118705582  MYO6; unconventional myosin-VI isoform X1 [KO:K10358]
118713673  MYO7A; unconventional myosin-VIIa [KO:K10359]
118720381  MYO7B; LOW QUALITY PROTEIN: unconventional myosin-VIIb [KO:K21868]
118729532  MYO9A; unconventional myosin-IXa isoform X1 [KO:K10360]
118706594  MYO9B; unconventional myosin-IXb isoform X1 [KO:K10360]
118703808  MYO10; unconventional myosin-X isoform X1 [KO:K12559]
118704453  MYO15B; myosin XVB [KO:K10361]
118727027  MYO15A; unconventional myosin-XV [KO:K10361]
118730296  MYO16; unconventional myosin-XVI [KO:K17481]
118725534  MYO18B; unconventional myosin-XVIIIb [KO:K10362]
118702595  MYO18A; unconventional myosin-XVIIIa isoform X1 [KO:K10362]
118726266  MYO19; unconventional myosin-XIX isoform X1 [KO:K25838]
118722949  MYH15; LOW QUALITY PROTEIN: myosin-15 [KO:K24220]
118707344  MYH7B; myosin-7B [KO:K24220]
118726888  myosin-1 [KO:K24220]
118726889  myosin-2 isoform X1 [KO:K24220]
118726890  myosin-3 [KO:K24220]
118726891  myosin-8 [KO:K24220]
118726892  myosin-4 [KO:K24220]
118726915  myosin-13 [KO:K24220]
118725393  myosin-6 isoform X1 [KO:K17751]
118703959  MYH11; myosin-11 isoform X1 [KO:K10352]
118730690  MYH9; LOW QUALITY PROTEIN: myosin-9 [KO:K10352]
118726887  MYH10; myosin-10 isoform X1 [KO:K10352]
118718827  MYH14; myosin-14 isoform X1 [KO:K10352]
118709027  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
118714797  MYL3; myosin light chain 3 isoform X1 [KO:K12749]
118726331  MYL4; myosin light chain 4 [KO:K12750]
118729438  MYL6B; myosin light chain 6B isoform X1 [KO:K12751]
118729439  MYL6; myosin light polypeptide 6 isoform X1 [KO:K12751]
118725474  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
118707132  MYL5; LOW QUALITY PROTEIN: myosin light chain 5 [KO:K12753]
118717996  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
118707702  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
118702716  MYL10; myosin regulatory light chain 10 isoform X1 [KO:K12756]
118708329  myosin regulatory light polypeptide 9 isoform X1 [KO:K12757]
118708330  myosin regulatory light chain 12B isoform X1 [KO:K12757]
118704821  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
118710309  ACTA1; actin, alpha skeletal muscle [KO:K10354]
118719269  ACTA2; actin, aortic smooth muscle [KO:K12313]
118723947  ACTC1; actin, alpha cardiac muscle 1 [KO:K12314]
118717547  ACTG2; actin, gamma-enteric smooth muscle [KO:K12315]
118704529  ACTG1; actin, cytoplasmic 2 [KO:K05692]
118710780  ACTB; actin, cytoplasmic 1 [KO:K05692]
118715154  TNNC1; troponin C, slow skeletal and cardiac muscles isoform X1 [KO:K05865]
118722260  TNNI1; troponin I, slow skeletal muscle [KO:K10371]
118715914  TNNT1; troponin T, slow skeletal muscle [KO:K10372]
118708371  LOW QUALITY PROTEIN: troponin C, skeletal muscle-like [KO:K12042]
118708373  troponin C, skeletal muscle [KO:K12042]
118708374  troponin C, skeletal muscle-like [KO:K12042]
118713965  TNNT3; troponin T, fast skeletal muscle isoform X1 [KO:K12046]
118715922  TNNI3; troponin I, cardiac muscle [KO:K12044]
118722259  TNNT2; troponin T, cardiac muscle [KO:K12045]
118716335  TPM2; tropomyosin beta chain isoform X1 [KO:K10374]
118721123  TPM3; tropomyosin alpha-3 chain isoform X1 [KO:K09290]
118706576  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
Reference
PMID:21092854
  Authors
Hirokawa N, Niwa S, Tanaka Y
  Title
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease.
  Journal
Neuron 68:610-38 (2010)
DOI:10.1016/j.neuron.2010.09.039
Reference
PMID:25470043 (PDB:4RH7)
  Authors
Schmidt H, Zalyte R, Urnavicius L, Carter AP
  Title
Structure of human cytoplasmic dynein-2 primed for its power stroke.
  Journal
Nature 518:435-438 (2015)
DOI:10.1038/nature14023
Reference
PMID:22398446 (PDB:3VKG 3VKH)
  Authors
Kon T, Oyama T, Shimo-Kon R, Imamula K, Shima T, Sutoh K, Kurisu G
  Title
The 2.8 A crystal structure of the dynein motor domain.
  Journal
Nature 484:345-50 (2012)
DOI:10.1038/nature10955
Reference
PMID:22997337 (PDB:3J1T 3J1U)
  Authors
Redwine WB, Hernandez-Lopez R, Zou S, Huang J, Reck-Peterson SL, Leschziner AE
  Title
Structural basis for microtubule binding and release by dynein.
  Journal
Science 337:1532-1536 (2012)
DOI:10.1126/science.1224151
Reference
PMID:26410600
  Authors
Gibbs KL, Greensmith L, Schiavo G
  Title
Regulation of Axonal Transport by Protein Kinases.
  Journal
Trends Biochem Sci 40:597-610 (2015)
DOI:10.1016/j.tibs.2015.08.003
Reference
PMID:28602352 (PDB:5NUG 5NVS 5NVU 5NW4)
  Authors
Zhang K, Foster HE, Rondelet A, Lacey SE, Bahi-Buisson N, Bird AW, Carter AP
  Title
Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated.
  Journal
Cell 169:1303-1314.e18 (2017)
DOI:10.1016/j.cell.2017.05.025
Reference
PMID:25814576 (PDB:5ADX 5AFR 5AFU)
  Authors
Urnavicius L, Zhang K, Diamant AG, Motz C, Schlager MA, Yu M, Patel NA, Robinson CV, Carter AP
  Title
The structure of the dynactin complex and its interaction with dynein.
  Journal
Science 347:1441-1446 (2015)
DOI:10.1126/science.aaa4080
Reference
PMID:29420470 (PDB:5OWO 6F1T 6F1U 6F1V 6F1Y 6F1Z 6F38 6F3A)
  Authors
Urnavicius L, Lau CK, Elshenawy MM, Morales-Rios E, Motz C, Yildiz A, Carter AP
  Title
Cryo-EM shows how dynactin recruits two dyneins for faster movement.
  Journal
Nature 554:202-206 (2018)
DOI:10.1038/nature25462
Reference
PMID:29662141
  Authors
Reck-Peterson SL, Redwine WB, Vale RD, Carter AP
  Title
The cytoplasmic dynein transport machinery and its many cargoes.
  Journal
Nat Rev Mol Cell Biol 19:382-398 (2018)
DOI:10.1038/s41580-018-0004-3
Reference
PMID:23434508 (PDB:3J2U)
  Authors
Asenjo AB, Chatterjee C, Tan D, DePaoli V, Rice WJ, Diaz-Avalos R, Silvestry M, Sosa H
  Title
Structural model for tubulin recognition and deformation by kinesin-13 microtubule depolymerases.
  Journal
Cell Rep 3:759-68 (2013)
DOI:10.1016/j.celrep.2013.01.030
Reference
PMID:10338210 (PDB:1B7T)
  Authors
Houdusse A, Kalabokis VN, Himmel D, Szent-Gyorgyi AG, Cohen C
  Title
Atomic structure of scallop myosin subfragment S1 complexed with MgADP: a novel conformation of the myosin head.
  Journal
Cell 97:459-70 (1999)
DOI:10.1016/s0092-8674(00)80756-4
Reference
PMID:9428521 (PDB:3KIN)
  Authors
Kozielski F, Sack S, Marx A, Thormahlen M, Schonbrunn E, Biou V, Thompson A, Mandelkow EM, Mandelkow E
  Title
The crystal structure of dimeric kinesin and implications for microtubule-dependent motility.
  Journal
Cell 91:985-94 (1997)
DOI:10.1016/s0092-8674(00)80489-4
Reference
PMID:8316857 (PDB:2MYS)
  Authors
Rayment I, Rypniewski WR, Schmidt-Base K, Smith R, Tomchick DR, Benning MM, Winkelmann DA, Wesenberg G, Holden HM
  Title
Three-dimensional structure of myosin subfragment-1: a molecular motor.
  Journal
Science 261:50-8 (1993)
DOI:10.1126/science.8316857
Reference
PMID:20428469
  Authors
Parker D, Bryant Z, Delp SL
  Title
Coarse-Grained Structural Modeling of Molecular Motors Using Multibody Dynamics.
  Journal
Cell Mol Bioeng 2:366-374 (2009)
DOI:10.1007/s12195-009-0084-4
Reference
PMID:21314430
  Authors
Dominguez R, Holmes KC
  Title
Actin structure and function.
  Journal
Annu Rev Biophys 40:169-86 (2011)
DOI:10.1146/annurev-biophys-042910-155359
Reference
PMID:31919429 (PDB:6KN7 6KN8)
  Authors
Yamada Y, Namba K, Fujii T
  Title
Cardiac muscle thin filament structures reveal calcium regulatory mechanism.
  Journal
Nat Commun 11:153 (2020)
DOI:10.1038/s41467-019-14008-1
Reference
PMID:33912943
  Authors
Kruppa AJ, Buss F
  Title
Motor proteins at the mitochondria-cytoskeleton interface.
  Journal
J Cell Sci 134:239092 (2021)
DOI:10.1242/jcs.226084
KO pathway
ko04814   
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