KEGG   PATHWAY: pleu00330
Entry
pleu00330                   Pathway                                
Name
Arginine and proline metabolism - Peromyscus leucopus (white-footed mouse)
Class
Metabolism; Amino acid metabolism
Pathway map
pleu00330  Arginine and proline metabolism
pleu00330

Module
pleu_M00015  Proline biosynthesis, glutamate => proline [PATH:pleu00330]
pleu_M00047  Creatine pathway [PATH:pleu00330]
pleu_M00134  Polyamine biosynthesis, arginine => ornithine => putrescine [PATH:pleu00330]
pleu_M00135  GABA biosynthesis, eukaryotes, putrescine => GABA [PATH:pleu00330]
pleu_M00970  Proline degradation, proline => glutamate [PATH:pleu00330]
pleu_M00972  Proline metabolism [PATH:pleu00330]
Other DBs
GO: 0006525 0006560
Organism
Peromyscus leucopus (white-footed mouse) [GN:pleu]
Gene
114699609  Gatm; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
114684128  Gamt; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
114699589  creatine kinase U-type, mitochondrial [KO:K00933] [EC:2.7.3.2]
114708041  Ckmt2; creatine kinase S-type, mitochondrial [KO:K00933] [EC:2.7.3.2]
114703066  Ckb; creatine kinase B-type [KO:K00933] [EC:2.7.3.2]
114709878  Ckm; creatine kinase M-type [KO:K27382] [EC:2.7.3.2]
114682045  Azin2; antizyme inhibitor 2 isoform X1 [KO:K01583] [EC:4.1.1.19]
114705638  antizyme inhibitor 2-like [KO:K01581] [EC:4.1.1.17]
114698847  Odc1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
114692386  spermidine synthase-like [KO:K00797] [EC:2.5.1.16]
114709664  Srm; spermidine synthase [KO:K00797] [EC:2.5.1.16]
114695779  Sms; spermine synthase [KO:K00802] [EC:2.5.1.22]
114687024  Amd1; S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
114700050  amiloride-sensitive amine oxidase [copper-containing]-like [KO:K11182] [EC:1.4.3.22]
114700051  amiloride-sensitive amine oxidase [copper-containing]-like [KO:K11182] [EC:1.4.3.22]
114700052  amiloride-sensitive amine oxidase [copper-containing]-like [KO:K11182] [EC:1.4.3.22]
114700053  amiloride-sensitive amine oxidase [copper-containing] [KO:K11182] [EC:1.4.3.22]
114699518  Smox; spermine oxidase isoform X1 [KO:K12259] [EC:1.5.3.16 1.5.3.-]
114683273  Aldh3a2; aldehyde dehydrogenase family 3 member A2 isoform X1 [KO:K00128] [EC:1.2.1.3]
114684962  Aldh1b1; aldehyde dehydrogenase X, mitochondrial [KO:K00128] [EC:1.2.1.3]
114687173  Aldh16a1; aldehyde dehydrogenase family 16 member A1 [KO:K00128] [EC:1.2.1.3]
114681892  Aldh2; aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
114706088  Aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
114689914  Aldh9a1; 4-trimethylaminobutyraldehyde dehydrogenase [KO:K00149] [EC:1.2.1.47 1.2.1.3]
114694603  4-trimethylaminobutyraldehyde dehydrogenase-like [KO:K00149] [EC:1.2.1.47 1.2.1.3]
114695271  4-trimethylaminobutyraldehyde dehydrogenase-like [KO:K00149] [EC:1.2.1.47 1.2.1.3]
114696268  Cndp1; beta-Ala-His dipeptidase [KO:K05604] [EC:3.4.13.20]
114696266  Cndp2; cytosolic non-specific dipeptidase [KO:K08660] [EC:3.4.13.18]
114685990  Carns1; carnosine synthase 1 isoform X2 [KO:K14755] [EC:6.3.2.11]
114693176  Sat2; thialysine N-epsilon-acetyltransferase isoform X1 [KO:K00657] [EC:2.3.1.57]
114695771  Sat1; diamine acetyltransferase 1 isoform X1 [KO:K00657] [EC:2.3.1.57]
114697630  Maob; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
114697631  amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
114700862  Agmat; agmatinase, mitochondrial [KO:K27001] [EC:3.5.3.- 3.5.3.7 3.5.3.17]
114699651  Nos1; nitric oxide synthase, brain isoform X2 [KO:K13240] [EC:1.14.13.39]
114691518  Nos2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
114700088  Nos3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
114697772  Arg2; arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
114698623  Arg1; arginase-1 [KO:K01476] [EC:3.5.3.1]
114692648  Oat; ornithine aminotransferase, mitochondrial [KO:K00819] [EC:2.6.1.13]
114690626  Pycr2; pyrroline-5-carboxylate reductase 2 isoform X1 [KO:K00286] [EC:1.5.1.2]
114684757  Pycr3; pyrroline-5-carboxylate reductase 3 [KO:K00286] [EC:1.5.1.2]
114680623  Pycr1; pyrroline-5-carboxylate reductase 1, mitochondrial isoform X1 [KO:K00286] [EC:1.5.1.2]
114685715  proline dehydrogenase 1, mitochondrial isoform X2 [KO:K00318] [EC:1.5.5.2]
114700893  Aldh4a1; delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial [KO:K00294] [EC:1.2.1.88]
114706868  Aldh18a1; delta-1-pyrroline-5-carboxylate synthase isoform X1 [KO:K12657] [EC:2.7.2.11 1.2.1.41]
114690879  Lap3; cytosol aminopeptidase [KO:K11142] [EC:3.4.11.1 3.4.11.5]
114705778  cytosol aminopeptidase-like [KO:K11142] [EC:3.4.11.1 3.4.11.5]
114698718  P4ha3; LOW QUALITY PROTEIN: prolyl 4-hydroxylase subunit alpha-3 [KO:K00472] [EC:1.14.11.2]
114700393  P4ha2; LOW QUALITY PROTEIN: prolyl 4-hydroxylase subunit alpha-2 [KO:K00472] [EC:1.14.11.2]
114708873  P4ha1; prolyl 4-hydroxylase subunit alpha-1 isoform X2 [KO:K00472] [EC:1.14.11.2]
114681696  Prodh2; hydroxyproline dehydrogenase isoform X2 [KO:K11394] [EC:1.5.5.3]
114686800  Got1l1; putative aspartate aminotransferase, cytoplasmic 2 [KO:K14454] [EC:2.6.1.1]
114706449  Got1; aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
114706282  Got2; aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
114706886  Hoga1; 4-hydroxy-2-oxoglutarate aldolase, mitochondrial isoform X1 [KO:K18123] [EC:4.1.3.16]
114686975  Dao; LOW QUALITY PROTEIN: D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
114683942  L3hypdh; trans-3-hydroxy-L-proline dehydratase [KO:K18384] [EC:4.2.1.77]
Compound
C00012  Peptide
C00019  S-Adenosyl-L-methionine
C00022  Pyruvate
C00025  L-Glutamate
C00048  Glyoxylate
C00062  L-Arginine
C00077  L-Ornithine
C00086  Urea
C00134  Putrescine
C00148  L-Proline
C00179  Agmatine
C00213  Sarcosine
C00223  p-Coumaroyl-CoA
C00300  Creatine
C00315  Spermidine
C00334  4-Aminobutanoate
C00406  Feruloyl-CoA
C00431  5-Aminopentanoate
C00436  N-Carbamoylputrescine
C00441  L-Aspartate 4-semialdehyde
C00533  Nitric oxide
C00555  4-Aminobutyraldehyde
C00581  Guanidinoacetate
C00750  Spermine
C00763  D-Proline
C00791  Creatinine
C00884  Homocarnosine
C00986  1,3-Diaminopropane
C01035  4-Guanidinobutanoate
C01043  N-Carbamoylsarcosine
C01110  5-Amino-2-oxopentanoic acid
C01137  S-Adenosylmethioninamine
C01157  Hydroxyproline
C01165  L-Glutamate 5-semialdehyde
C01250  N-Acetyl-L-glutamate 5-semialdehyde
C01682  Nopaline
C02305  Phosphocreatine
C02565  N-Methylhydantoin
C02647  4-Guanidinobutanal
C02714  N-Acetylputrescine
C02946  4-Acetamidobutanoate
C03078  4-Guanidinobutanamide
C03166  Phosphoguanidinoacetate
C03287  L-Glutamyl 5-phosphate
C03296  N2-Succinyl-L-arginine
C03375  Norspermidine
C03415  N2-Succinyl-L-ornithine
C03564  1-Pyrroline-2-carboxylate
C03771  5-Guanidino-2-oxopentanoate
C03912  (S)-1-Pyrroline-5-carboxylate
C04137  Octopine
C04281  L-1-Pyrroline-3-hydroxy-5-carboxylate
C05147  trans-3-Hydroxy-L-proline
C05931  N-Succinyl-L-glutamate
C05932  N-Succinyl-L-glutamate 5-semialdehyde
C05933  N(omega)-Hydroxyarginine
C05936  N4-Acetylaminobutanal
C05938  L-4-Hydroxyglutamate semialdehyde
C05945  L-Arginine phosphate
C05946  (4R)-4-Hydroxy-2-oxoglutarate
C05947  L-erythro-4-Hydroxyglutamate
C10497  Feruloylputrescine
C15699  gamma-L-Glutamylputrescine
C15700  gamma-Glutamyl-gamma-aminobutyraldehyde
C15767  4-(L-gamma-Glutamylamino)butanoate
C18172  Carboxyspermidine
C18174  Carboxynorspermidine
C18326  p-Coumaroylputrescine
C19706  cis-3-Hydroxy-L-proline
Reference
PMID:5288244
  Authors
Haake P, Allen GW.
  Title
Studies on phosphorylation by phosphoroguanidinates. The mechanism of action of creatine: ATP transphosphorylase (creatine kinase).
  Journal
Proc Natl Acad Sci U S A 68:2691-3 (1971)
DOI:10.1073/pnas.68.11.2691
Reference
PMID:16499623
  Authors
Kurihara S, Oda S, Kumagai H, Suzuki H.
  Title
Gamma-glutamyl-gamma-aminobutyrate hydrolase in the putrescine utilization pathway of Escherichia coli K-12.
  Journal
FEMS Microbiol Lett 256:318-23 (2006)
DOI:10.1111/j.1574-6968.2006.00137.x
Reference
PMID:15590624
  Authors
Kurihara S, Oda S, Kato K, Kim HG, Koyanagi T, Kumagai H, Suzuki H.
  Title
A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12.
  Journal
J Biol Chem 280:4602-8 (2005)
DOI:10.1074/jbc.M411114200
Related
pathway
pleu00020  Citrate cycle (TCA cycle)
pleu00220  Arginine biosynthesis
pleu00250  Alanine, aspartate and glutamate metabolism
pleu00260  Glycine, serine and threonine metabolism
pleu00270  Cysteine and methionine metabolism
pleu00310  Lysine degradation
pleu00410  beta-Alanine metabolism
pleu00470  D-Amino acid metabolism
pleu00480  Glutathione metabolism
pleu00630  Glyoxylate and dicarboxylate metabolism
pleu00650  Butanoate metabolism
pleu00770  Pantothenate and CoA biosynthesis
KO pathway
ko00330   
LinkDB

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