KEGG   PATHWAY: pleu00260
Entry
pleu00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Peromyscus leucopus (white-footed mouse)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pleu00260  Glycine, serine and threonine metabolism
pleu00260

Module
pleu_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pleu00260]
pleu_M00047  Creatine pathway [PATH:pleu00260]
pleu_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:pleu00260]
pleu_M00555  Betaine biosynthesis, choline => betaine [PATH:pleu00260]
pleu_M00621  Glycine cleavage system [PATH:pleu00260]
pleu_M00974  Betaine metabolism, animals, betaine => glycine [PATH:pleu00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Peromyscus leucopus (white-footed mouse) [GN:pleu]
Gene
114708941  probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]
114683284  Shmt1; LOW QUALITY PROTEIN: serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
114704793  Shmt2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
114707822  Agxt; serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
114710576  Grhpr; glyoxylate reductase/hydroxypyruvate reductase isoform X1 [KO:K00049] [EC:1.1.1.79 1.1.1.81]
114693505  Glyctk; glycerate kinase isoform X2 [KO:K11529] [EC:2.7.1.165]
114706875  Pgam1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
114693985  Pgam2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
114691032  Bpgm; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
114686257  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
114688197  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
114696909  Psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
114693677  Psph; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
114694246  Gcat; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
114703375  L-threonine 3-dehydrogenase, mitochondrial isoform X3 [KO:K15789] [EC:1.1.1.103]
114710976  Alas1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]
114702868  Alas2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
114697630  Maob; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
114697631  amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
114682821  Aoc3; LOW QUALITY PROTEIN: membrane primary amine oxidase [KO:K00276] [EC:1.4.3.21]
114682828  Aoc2; retina-specific copper amine oxidase [KO:K00276] [EC:1.4.3.21]
114710511  Gldc; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
114705214  Amt; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
114708456  Dld; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
114681394  glycine cleavage system H protein, mitochondrial [KO:K02437]
114697452  Gcsh; glycine cleavage system H protein, mitochondrial [KO:K02437]
114693457  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
114686975  Dao; LOW QUALITY PROTEIN: D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
114710800  Agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
114699609  Gatm; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
114684128  Gamt; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
114686205  Chdh; choline dehydrogenase, mitochondrial isoform X1 [KO:K00108] [EC:1.1.99.1]
114705405  LOW QUALITY PROTEIN: choline dehydrogenase, mitochondrial-like [KO:K00108] [EC:1.1.99.1]
114706088  Aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
114694686  Bhmt; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
114694633  Dmgdh; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
114691481  Pipox; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
114684225  Sardh; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
114705340  Gnmt; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
114704001  Cbs; cystathionine beta-synthase isoform X1 [KO:K01697] [EC:4.2.1.22]
114707605  Cth; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
114699636  Sds; L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
114699637  Sdsl; serine dehydratase-like isoform X1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
114691421  Srr; LOW QUALITY PROTEIN: serine racemase [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pleu00010  Glycolysis / Gluconeogenesis
pleu00020  Citrate cycle (TCA cycle)
pleu00230  Purine metabolism
pleu00250  Alanine, aspartate and glutamate metabolism
pleu00270  Cysteine and methionine metabolism
pleu00290  Valine, leucine and isoleucine biosynthesis
pleu00330  Arginine and proline metabolism
pleu00470  D-Amino acid metabolism
pleu00564  Glycerophospholipid metabolism
pleu00600  Sphingolipid metabolism
pleu00620  Pyruvate metabolism
pleu00630  Glyoxylate and dicarboxylate metabolism
pleu00640  Propanoate metabolism
pleu00860  Porphyrin metabolism
pleu00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system