KEGG   PATHWAY: pleu00983
Entry
pleu00983                   Pathway                                
Name
Drug metabolism - other enzymes - Peromyscus leucopus (white-footed mouse)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
pleu00983  Drug metabolism - other enzymes
pleu00983

Organism
Peromyscus leucopus (white-footed mouse) [GN:pleu]
Gene
114705281  Hprt1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
114691090  Impdh1; inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
114705205  Impdh2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
114710396  Gmps; GMP synthase [glutamine-hydrolyzing] isoform X2 [KO:K01951] [EC:6.3.5.2]
114692065  Tpmt; thiopurine S-methyltransferase isoform X1 [KO:K00569] [EC:2.1.1.67]
114696109  Xdh; LOW QUALITY PROTEIN: xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
114699500  Itpa; inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
114694523  LOW QUALITY PROTEIN: carboxylesterase 1D-like [KO:K01044] [EC:3.1.1.1]
114694524  liver carboxylesterase 1F-like isoform X1 [KO:K01044] [EC:3.1.1.1]
114694526  LOW QUALITY PROTEIN: carboxylesterase 1E-like [KO:K01044] [EC:3.1.1.1]
114694527  LOW QUALITY PROTEIN: carboxylesterase 1C-like [KO:K01044] [EC:3.1.1.1]
114694563  carboxylesterase 1E-like [KO:K01044] [EC:3.1.1.1]
114694525  LOW QUALITY PROTEIN: liver carboxylesterase 1-like [KO:K01044] [EC:3.1.1.1]
114694522  liver carboxylesterase 1-like isoform X1 [KO:K01044] [EC:3.1.1.1]
114681095  pyrethroid hydrolase Ces2e-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
114681071  LOW QUALITY PROTEIN: acylcarnitine hydrolase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
114681081  acylcarnitine hydrolase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
114681082  pyrethroid hydrolase Ces2e-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
114681092  acylcarnitine hydrolase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
114681101  acylcarnitine hydrolase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
114689099  acylcarnitine hydrolase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
114703551  acylcarnitine hydrolase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
114681072  acylcarnitine hydrolase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
114703526  acylcarnitine hydrolase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
114703533  acylcarnitine hydrolase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
114689652  UDP-glucuronosyltransferase 2A1 isoform X1 [KO:K00699] [EC:2.4.1.17]
114689669  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
114689681  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
114697845  UDP-glucuronosyltransferase 1A7-like [KO:K00699] [EC:2.4.1.17]
114697846  UDP-glucuronosyltransferase 1A9-like [KO:K00699] [EC:2.4.1.17]
114697847  UDP-glucuronosyltransferase 1A9-like [KO:K00699] [EC:2.4.1.17]
114697897  UDP-glucuronosyltransferase 1A1 isoform X2 [KO:K00699] [EC:2.4.1.17]
114707468  UDP-glucuronosyltransferase 2A3-like isoform X1 [KO:K00699] [EC:2.4.1.17]
114707555  UDP-glucuronosyltransferase 2B17-like isoform X1 [KO:K00699] [EC:2.4.1.17]
114707680  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
114707815  UDP-glucuronosyltransferase 2B1-like [KO:K00699] [EC:2.4.1.17]
114707886  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
114707957  UDP-glucuronosyltransferase 2B1 [KO:K00699] [EC:2.4.1.17]
114708159  UDP-glucuronosyltransferase 2B31-like isoform X1 [KO:K00699] [EC:2.4.1.17]
114708219  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
114708309  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
114693669  Gusb; beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
114697192  Cda; cytidine deaminase isoform X1 [KO:K01489] [EC:3.5.4.5]
114693029  thymidine phosphorylase isoform X2 [KO:K00758] [EC:2.4.2.4]
114700463  Dpyd; dihydropyrimidine dehydrogenase [NADP(+)] isoform X1 [KO:K00207] [EC:1.3.1.2]
114699923  Dpys; dihydropyrimidinase isoform X1 [KO:K01464] [EC:3.5.2.2]
114696484  Upb1; beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
114708036  Upp1; uridine phosphorylase 1 isoform X1 [KO:K00757] [EC:2.4.2.3]
114695769  Upp2; uridine phosphorylase 2 isoform X1 [KO:K00757] [EC:2.4.2.3]
114689917  Uck2; uridine-cytidine kinase 2 [KO:K00876] [EC:2.7.1.48]
114704160  Uckl1; uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
114703795  Uck1; uridine-cytidine kinase 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
114708957  Tk1; thymidine kinase, cytosolic [KO:K00857] [EC:2.7.1.21]
114703538  Tk2; LOW QUALITY PROTEIN: thymidine kinase 2, mitochondrial [KO:K00857] [EC:2.7.1.21]
114704848  Umps; LOW QUALITY PROTEIN: uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
114685781  LOW QUALITY PROTEIN: UMP-CMP kinase-like [KO:K13800] [EC:2.7.4.14]
114706659  Cmpk1; UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
114706610  Rrm1; ribonucleoside-diphosphate reductase large subunit isoform X1 [KO:K10807] [EC:1.17.4.1]
114683031  Rrm2b; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
114698849  Rrm2; ribonucleoside-diphosphate reductase subunit M2 isoform X1 [KO:K10808] [EC:1.17.4.1]
114681239  Nme4; nucleoside diphosphate kinase, mitochondrial isoform X1 [KO:K00940] [EC:2.7.4.6]
114681246  Nme3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
114689940  Nme7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
114705248  Nme6; nucleoside diphosphate kinase 6 isoform X1 [KO:K00940] [EC:2.7.4.6]
114699478  nucleoside diphosphate kinase B-like [KO:K00940] [EC:2.7.4.6]
114692876  nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
114692877  nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
114683901  Dut; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial [KO:K01520] [EC:3.6.1.23]
114699237  myeloperoxidase-like [KO:K10789] [EC:1.11.2.2]
114699257  myeloperoxidase [KO:K10789] [EC:1.11.2.2]
114703125  arylamine N-acetyltransferase 2 isoform X1 [KO:K00622] [EC:2.3.1.5]
114703126  arylamine N-acetyltransferase 1 [KO:K00622] [EC:2.3.1.5]
114703138  LOW QUALITY PROTEIN: arylamine N-acetyltransferase 3-like [KO:K00622] [EC:2.3.1.5]
114693387  cytochrome P450 2E1 isoform X1 [KO:K07415] [EC:1.14.14.-]
114686535  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
114686793  glutathione S-transferase A2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
114686794  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
114686795  glutathione S-transferase alpha-1-like [KO:K00799] [EC:2.5.1.18]
114686796  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
114686797  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
114686798  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
114687986  glutathione S-transferase alpha-4-like [KO:K00799] [EC:2.5.1.18]
114689912  Mgst3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
114692337  glutathione S-transferase A6 [KO:K00799] [EC:2.5.1.18]
114692338  glutathione S-transferase alpha-3 [KO:K00799] [EC:2.5.1.18]
114692339  glutathione S-transferase alpha-5 [KO:K00799] [EC:2.5.1.18]
114692342  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
114692343  glutathione S-transferase alpha-3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
114699990  glutathione S-transferase Mu 7 isoform X2 [KO:K00799] [EC:2.5.1.18]
114699991  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
114699992  glutathione S-transferase Mu 2 [KO:K00799] [EC:2.5.1.18]
114699993  glutathione S-transferase Mu 6 [KO:K00799] [EC:2.5.1.18]
114699994  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
114699995  glutathione S-transferase Mu 2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
114699996  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
114699997  glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
114699999  Gstm3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
114695037  Mgst1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
114695881  Mgst2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
114696494  glutathione S-transferase theta-3 [KO:K00799] [EC:2.5.1.18]
114696495  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
114696497  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
114696498  glutathione S-transferase theta-2 [KO:K00799] [EC:2.5.1.18]
114696706  glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
114696723  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
114694764  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
114694770  glutathione S-transferase P-like isoform X1 [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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