KEGG   PATHWAY: pmr00230
Entry
pmr00230                    Pathway                                
Name
Purine metabolism - Proteus mirabilis HI4320
Class
Metabolism; Nucleotide metabolism
Pathway map
pmr00230  Purine metabolism
pmr00230

Module
pmr_M00005  PRPP biosynthesis, ribose-5P => PRPP [PATH:pmr00230]
pmr_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:pmr00230]
pmr_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:pmr00230]
pmr_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:pmr00230]
pmr_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:pmr00230]
Other DBs
GO: 0006163 0042278
Organism
Proteus mirabilis HI4320 [GN:pmr]
Gene
PMI0045  cpdB; 2',3'-cyclic-nucleotide 2'-phosphodiesterase precursor [KO:K01119] [EC:3.1.4.16 3.1.3.6]
PMI0047  [KO:K01081] [EC:3.1.3.5]
PMI0138  apt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
PMI0160  hpt; hypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
PMI0215  dgt; deoxyguanosinetriphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
PMI0217  relA; GTP pyrophosphokinase [KO:K00951] [EC:2.7.6.5]
PMI0218  mazG; putative nucleotide pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
PMI0333  [KO:K01519] [EC:3.6.1.66]
PMI0366  gpt; xanthine-guanine phosphoribosyltransferase [KO:K00769] [EC:2.4.2.22]
PMI0394  [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
PMI0413  nrdF; ribonucleoside-diphosphate reductase beta chain [KO:K00526] [EC:1.17.4.1]
PMI0414  nrdE; ribonucleoside-diphosphate reductase alpha chain [KO:K00525] [EC:1.17.4.1]
PMI0548  pgm; phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
PMI0702  allD; ureidoglycolate dehydrogenase [KO:K00073] [EC:1.1.1.350]
PMI0886  purB; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
PMI1004  [KO:K05873] [EC:4.6.1.1]
PMI1083  prsA; ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
PMI1220  amn; putative AMP nucleosidase [KO:K01241] [EC:3.2.2.4]
PMI1300  add; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
PMI1545  guaA; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
PMI1546  guaB; inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
PMI1562  purC; phosphoribosylaminoimidazole-succinocarboxamide synthetase (SAICAR synthetase) [KO:K01923] [EC:6.3.2.6]
PMI1575  purM; phosphoribosylformylglycinamidine cyclo-ligase (phosphoribosyl-aminoimidazole synthetase) [KO:K01933] [EC:6.3.3.1]
PMI1576  purN; phosphoribosylglycinamide formyltransferase (5'-phosphoribosylglycinamide transformylase) [KO:K11175] [EC:2.1.2.2]
PMI1579  ppx; exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
PMI1734  nrdA; ribonucleoside-diphosphate reductase 1 alpha chain [KO:K00525] [EC:1.17.4.1]
PMI1735  nrdB; ribonucleoside-diphosphate reductase 1, beta subunit [KO:K00526] [EC:1.17.4.1]
PMI1766  [KO:K08722] [EC:3.1.3.89]
PMI1783  purF; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
PMI1849  ndk; nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
PMI1875  purL; phosphoribosylformylglycineamide synthetase [KO:K01952] [EC:6.3.5.3]
PMI2161  purE; phosphoribosylaminoimidazole carboxylase catalytic subunit [KO:K01588] [EC:5.4.99.18]
PMI2162  purK; phosphoribosylaminoimidazole carboxylase ATPase subunit [KO:K01589] [EC:6.3.4.18]
PMI2177  ushA; protein UshA precursor [includes: UDP-sugar hydrolase and 5'-nucleotidase] [KO:K11751] [EC:3.1.3.5 3.6.1.45]
PMI2181  gsk; inosine-guanosine kinase [KO:K00892] [EC:2.7.1.73]
PMI2184  adk; adenylate kinase [KO:K00939] [EC:2.7.4.3]
PMI2187  purT; phosphoribosylglycinamide formyltransferase [KO:K08289] [EC:6.3.1.21]
PMI2199  arcC; putative carbamate [KO:K00926] [EC:2.7.2.2]
PMI2200  [KO:K28795]
PMI2201  [KO:K28794]
PMI2202  fdrA; protein FdrA (multicopy suppressor of dominant negative ftsH mutants) [KO:K02381] [EC:2.1.3.5]
PMI2239  surE; multifunctional protein SurE (stationary-phase survival protein SurE) [includes: 5'/3'-nucleotidase and exopolyphosphatase] [KO:K03787] [EC:3.1.3.5 3.1.3.6]
PMI2244  cysC; adenylyl-sulfate kinase [KO:K00860] [EC:2.7.1.25]
PMI2245  cysN; sulfate adenylyltransferase subunit 1 [KO:K00956] [EC:2.7.7.4]
PMI2246  cysD; sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
PMI2297  [KO:K06966] [EC:3.2.2.10 3.2.2.-]
PMI2336  apaH; bis(5'-nucleosyl)-tetraphosphatase [KO:K01525] [EC:3.6.1.41]
PMI2347  icc; cyclic 3',5'-adenosine monophosphate phosphodiesterase [KO:K03651] [EC:3.1.4.53]
PMI2348  nudF; ADP-ribose pyrophosphatase [KO:K01515] [EC:3.6.1.13 3.6.1.-]
PMI2413  deoD; purine nucleoside phosphorylase [KO:K03784] [EC:2.4.2.1]
PMI2414  deoB; phosphopentomutase [KO:K01839] [EC:5.4.2.7]
PMI2768  purH; bifunctional purine biosynthesis protein [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase and IMP cyclohydrolase] [KO:K00602] [EC:2.1.2.3 3.5.4.10]
PMI2769  purD; phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
PMI2862  gmk; guanylate kinase [KO:K00942] [EC:2.7.4.8]
PMI2864  spoT; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
PMI2981  [KO:K01756] [EC:4.3.2.2]
PMI3019  nudE; ADP compounds hydrolase [KO:K08312] [EC:3.6.1.-]
PMI3311  gppA; guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
PMI3333  cyaA; adenylate cyclase [KO:K05851] [EC:4.6.1.1]
PMI3370  purA; adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
PMI3451  nrdD; anaerobic ribonucleoside-triphosphate reductase [KO:K21636] [EC:1.1.98.6]
PMI3501  [KO:K01129] [EC:3.1.5.1]
PMI3683  ureA; urease gamma subunit [KO:K01430] [EC:3.5.1.5]
PMI3684  ureB; urease beta subunit [KO:K01429] [EC:3.5.1.5]
PMI3685  ureC; urease alpha subunit [KO:K01428] [EC:3.5.1.5]
PMI3715  [KO:K01529]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
pmr00030  Pentose phosphate pathway
pmr00220  Arginine biosynthesis
pmr00250  Alanine, aspartate and glutamate metabolism
pmr00260  Glycine, serine and threonine metabolism
pmr00340  Histidine metabolism
pmr00630  Glyoxylate and dicarboxylate metabolism
pmr00730  Thiamine metabolism
pmr00740  Riboflavin metabolism
pmr00790  Folate biosynthesis
KO pathway
ko00230   

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