KEGG   PATHWAY: por00260
Entry
por00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Pseudomonas oryzihabitans
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
por00260  Glycine, serine and threonine metabolism
por00260

Module
por_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:por00260]
por_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:por00260]
por_M00555  Betaine biosynthesis, choline => betaine [PATH:por00260]
por_M00621  Glycine cleavage system [PATH:por00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pseudomonas oryzihabitans [GN:por]
Gene
APT59_07560  aspartate kinase [KO:K00928] [EC:2.7.2.4]
APT59_12720  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
APT59_17620  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
APT59_00735  homoserine kinase [KO:K02204] [EC:2.7.1.39]
APT59_17615  threonine synthase [KO:K01733] [EC:4.2.3.1]
APT59_07550  threonine aldolase [KO:K01620] [EC:4.1.2.48]
APT59_21040  threonine aldolase [KO:K01620] [EC:4.1.2.48]
APT59_03565  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
APT59_21565  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
APT59_03530  glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
APT59_10590  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
APT59_03840  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
APT59_10520  glycerate kinase [KO:K00865] [EC:2.7.1.165]
APT59_21110  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
APT59_07790  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
APT59_16125  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
APT59_19105  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
APT59_15220  3-phosphoserine/phosphohydroxythreonine aminotransferase [KO:K00831] [EC:2.6.1.52]
APT59_19705  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
APT59_03455  amine oxidase [KO:K00274] [EC:1.4.3.4]
APT59_00940  glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
APT59_00945  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
APT59_08995  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
APT59_06990  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
APT59_18460  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
APT59_00935  glycine cleavage system protein H [KO:K02437]
APT59_20255  glycine cleavage system protein H [KO:K02437]
APT59_02170  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
APT59_00850  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
APT59_14950  aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
APT59_00855  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
APT59_00365  Rieske (2Fe-2S) protein [KO:K00479] [EC:1.14.13.251]
APT59_03945  (Fe-S)-binding protein [KO:K00479] [EC:1.14.13.251]
APT59_03940  hybrid-cluster NAD(P)-dependent oxidoreductase [KO:K21832] [EC:1.14.13.251]
APT59_00370  hybrid-cluster NAD(P)-dependent oxidoreductase [KO:K21832] [EC:1.14.13.251]
APT59_00705  N-methylproline demethylase [KO:K21833] [EC:1.5.7.3]
APT59_00710  (Fe-S)-binding protein [KO:K21834]
APT59_00720  electron transfer flavoprotein subunit beta [KO:K25961]
APT59_10435  methyltryptophan oxidase [KO:K00301] [EC:1.5.3.1]
APT59_21550  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
APT59_21560  sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
APT59_21545  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
APT59_21555  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
APT59_19730  serine dehydratase [KO:K01752] [EC:4.3.1.17]
APT59_19805  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
APT59_19095  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
APT59_04005  amino acid deaminase [KO:K01753] [EC:4.3.1.18]
APT59_05640  racemase [KO:K25316] [EC:5.1.1.10]
APT59_00340  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
APT59_00335  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
APT59_13240  2,4-diaminobutyrate 4-aminotransferase [KO:K00836] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
por00010  Glycolysis / Gluconeogenesis
por00020  Citrate cycle (TCA cycle)
por00230  Purine metabolism
por00250  Alanine, aspartate and glutamate metabolism
por00270  Cysteine and methionine metabolism
por00290  Valine, leucine and isoleucine biosynthesis
por00300  Lysine biosynthesis
por00330  Arginine and proline metabolism
por00460  Cyanoamino acid metabolism
por00470  D-Amino acid metabolism
por00564  Glycerophospholipid metabolism
por00620  Pyruvate metabolism
por00630  Glyoxylate and dicarboxylate metabolism
por00640  Propanoate metabolism
por00680  Methane metabolism
por00860  Porphyrin metabolism
por00920  Sulfur metabolism
KO pathway
ko00260   
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