KEGG   PATHWAY: pou00270
Entry
pou00270                    Pathway                                
Name
Cysteine and methionine metabolism - Penicillium oxalicum
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
pou00270  Cysteine and methionine metabolism
pou00270

Module
pou_M00017  Methionine biosynthesis, aspartate => homoserine => methionine [PATH:pou00270]
pou_M00035  Methionine degradation [PATH:pou00270]
pou_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:pou00270]
Other DBs
GO: 0006534 0006555
Organism
Penicillium oxalicum [GN:pou]
Gene
POX_h09812  Cysteine synthase 2 [KO:K01738] [EC:2.5.1.47]
POX_f08313  Cysteine synthase 1 [KO:K01738] [EC:2.5.1.47]
POX_a00850  Homocysteine synthase [KO:K17069] [EC:2.5.1.49 2.5.1.47]
POX_c04366  Cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
POX_b02262  Cystathionine beta-lyase [KO:K01760] [EC:4.4.1.13]
POX_f08136  Cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
POX_a00321  hypothetical protein [KO:K00547] [EC:2.1.1.10]
POX_f07791  putative 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase [KO:K00549] [EC:2.1.1.14]
POX_d05566  S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
POX_a00471  hypothetical protein [KO:K01611] [EC:4.1.1.50]
POX_c03663  Spermidine synthase [KO:K00797] [EC:2.5.1.16]
POX_a01153  S-methyl-5'-thioadenosine phosphorylase [KO:K00772] [EC:2.4.2.28]
POX_f08490  Methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
POX_a01338  Methylthioribulose-1-phosphate dehydratase [KO:K08964] [EC:4.2.1.109]
POX_f07720  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase [KO:K08967] [EC:1.13.11.53 1.13.11.54]
POX_a00237  Aminotransferase swnA [KO:K00838] [EC:2.6.1.57 2.6.1.39 2.6.1.27 2.6.1.5]
POX_a01329  Aromatic amino acid aminotransferase [KO:K00838] [EC:2.6.1.57 2.6.1.39 2.6.1.27 2.6.1.5]
POX_b03290  Free methionine-R-sulfoxide reductase [KO:K08968] [EC:1.8.4.14]
POX_f07640  hypothetical protein [KO:K00558] [EC:2.1.1.37]
POX_d05665  Adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]
POX_a00493  hypothetical protein [KO:K01505] [EC:3.5.99.7]
POX_e06337  Aspartokinase [KO:K00928] [EC:2.7.2.4]
POX_g08820  Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
POX_e06604  Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
POX_b03128  Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
POX_a00267  Homoserine O-acetyltransferase [KO:K00641] [EC:2.3.1.31 2.3.1.46]
POX_g09137  Cystathionine gamma-synthase [KO:K01739] [EC:2.5.1.48]
POX_f08212  putative cystathionine gamma-synthase [KO:K01739] [EC:2.5.1.48]
POX_f07935  Branched-chain-amino-acid aminotransferase, cytosolic [KO:K00826] [EC:2.6.1.42]
POX_f08129  Aminotransferase atnJ [KO:K00826] [EC:2.6.1.42]
POX_a00927  Branched-chain-amino-acid aminotransferase [KO:K00826] [EC:2.6.1.42]
POX_b03459  Aminotransferase lcsP [KO:K00826] [EC:2.6.1.42]
POX_c04748  Aminotransferase atnJ [KO:K00826] [EC:2.6.1.42]
POX_g08609  Glutamate--cysteine ligase [KO:K11204] [EC:6.3.2.2]
POX_b02809  hypothetical protein [KO:K11205]
POX_a00658  hypothetical protein [KO:K21456] [EC:6.3.2.3]
POX_b03398  Cysteine dioxygenase [KO:K00456] [EC:1.13.11.20]
POX_f07530  Aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
POX_f07855  Aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
POX_f08050  Aspartate aminotransferase [KO:K14455] [EC:2.6.1.1]
POX_d06115  hypothetical protein [KO:K01011] [EC:2.8.1.1 2.8.1.2]
POX_b01976  Thiosulfate sulfurtransferase TUM1 [KO:K01011] [EC:2.8.1.1 2.8.1.2]
POX_g09158  L-lactate dehydrogenase A [KO:K00016] [EC:1.1.1.27]
POX_c04641  hypothetical protein [KO:K00016] [EC:1.1.1.27]
POX_e06184  malate dehydrogenase [KO:K00026] [EC:1.1.1.37]
POX_c04450  malate dehydrogenase [KO:K00026] [EC:1.1.1.37]
POX_b02308  Serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
POX_e06350  D-3-phosphoglycerate dehydrogenase 2 [KO:K00058] [EC:1.1.1.95 1.1.1.399]
POX_a00945  hypothetical protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
POX_c04491  Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
pou00010  Glycolysis / Gluconeogenesis
pou00250  Alanine, aspartate and glutamate metabolism
pou00260  Glycine, serine and threonine metabolism
pou00290  Valine, leucine and isoleucine biosynthesis
pou00430  Taurine and hypotaurine metabolism
pou00480  Glutathione metabolism
pou00620  Pyruvate metabolism
pou00640  Propanoate metabolism
pou00770  Pantothenate and CoA biosynthesis
pou00900  Terpenoid backbone biosynthesis
pou00920  Sulfur metabolism
KO pathway
ko00270   
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