KEGG   PATHWAY: ppsd00600
Entry
ppsd00600                   Pathway                                
Name
Sphingolipid metabolism - Podospora pseudocomata
Class
Metabolism; Lipid metabolism
Pathway map
ppsd00600  Sphingolipid metabolism
ppsd00600

Module
ppsd_M00094  Ceramide biosynthesis [PATH:ppsd00600]
ppsd_M00099  Sphingosine biosynthesis [PATH:ppsd00600]
ppsd_M00100  Sphingosine degradation [PATH:ppsd00600]
Other DBs
GO: 0006665
Organism
Podospora pseudocomata [GN:ppsd]
Gene
QC762_706850  LCB2; serine palmitoyltransferase component [KO:K00654] [EC:2.3.1.50]
QC762_508370  LCB1; serine palmitoyltransferase component [KO:K00654] [EC:2.3.1.50]
QC762_708000  TSC10; 3-dehydrosphinganine reductase [KO:K04708] [EC:1.1.1.102]
QC762_705990  LAG1_2; sphingosine N-acyltransferase lag1 [KO:K04709] [EC:2.3.1.297]
QC762_122190  lag1; Sphingosine N-acyltransferase lag1 [KO:K04709] [EC:2.3.1.297]
QC762_201900  uncharacterized protein [KO:K12349] [EC:3.5.1.23]
QC762_406950  hypothetical protein [KO:K12349] [EC:3.5.1.23]
QC762_118530  YDC1; alkaline ceramidase ydc1 [KO:K04711] [EC:3.5.1.-]
QC762_213140  DES1; sphingolipid delta-4 desaturase [KO:K04712] [EC:1.14.19.17 1.14.18.5]
QC762_710100  SUR2; Sphingolipid C4-hydroxylase sur2 [KO:K04713] [EC:1.14.18.5]
QC762_102820  ISC1; phospholipase C type enzyme [KO:K12351] [EC:3.1.4.12]
QC762_305820  LCB3; Long-chain base-1-phosphate phosphatase [KO:K23451] [EC:3.1.3.-]
QC762_301800  LCB4; sphinganine kinase lcb4 [KO:K04718] [EC:2.7.1.91]
QC762_307920  DPL1; Dihydrosphingosine phosphate lyase [KO:K01634] [EC:4.1.2.27]
QC762_207510  HSX11_3; Ceramide glucosyltransferase [KO:K00720] [EC:2.4.1.80]
QC762_105180  LAC4; Beta-galactosidase (Lactase) [KO:K01190] [EC:3.2.1.23]
QC762_302620  hypothetical protein [KO:K01190] [EC:3.2.1.23]
QC762_407810  hypothetical protein [KO:K01190] [EC:3.2.1.23]
QC762_506680  hypothetical protein [KO:K07407] [EC:3.2.1.22]
QC762_607390  hypothetical protein [KO:K07407] [EC:3.2.1.22]
QC762_109530  NAG1_1; Glucosamine-6-phosphate isomerase (Glucosamine-6-phosphate deaminase) (GNPDA) (GlcN6P deaminase) [KO:K12373] [EC:3.2.1.52]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
ppsd00260  Glycine, serine and threonine metabolism
ppsd00603  Glycosphingolipid biosynthesis - globo and isoglobo series
ppsd00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   
LinkDB

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