KEGG   PATHWAY: ppun00260
Entry
ppun00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Pseudomonas putida NBRC 14164
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ppun00260  Glycine, serine and threonine metabolism
ppun00260

Module
ppun_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ppun00260]
ppun_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ppun00260]
ppun_M00555  Betaine biosynthesis, choline => betaine [PATH:ppun00260]
ppun_M00621  Glycine cleavage system [PATH:ppun00260]
ppun_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:ppun00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pseudomonas putida NBRC 14164 [GN:ppun]
Gene
PP4_13490  lysC; aspartokinase [KO:K00928] [EC:2.7.2.4]
PP4_38430  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
PP4_42410  hom; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
PP4_01130  thrB; homoserine kinase [KO:K02204] [EC:2.7.1.39]
PP4_42400  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
PP4_03480  ltaE; L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
PP4_03490  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
PP4_46040  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
PP4_31280  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
PP4_45150  hprA; glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
PP4_20480  hprA; glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
PP4_16840  ghrA; glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
PP4_07740  putative oxidoreductase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
PP4_25540  glycerate kinase [KO:K00865] [EC:2.7.1.165]
PP4_14660  putative hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
PP4_51200  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
PP4_19640  putative oxidoreductase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
PP4_26660  gyaR; glyoxylate reductase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
PP4_52200  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
PP4_40030  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
PP4_49760  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
PP4_05220  putative oxidoreductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
PP4_19560  lao; L-amino acid oxidase [KO:K00274] [EC:1.4.3.4]
PP4_50490  putative oxidoreductase [KO:K00274] [EC:1.4.3.4]
PP4_52640  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
PP4_31290  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
PP4_43220  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
PP4_52660  gcvT; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
PP4_43240  gcvT; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
PP4_54290  lpd; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
PP4_15710  lpd; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
PP4_13570  bkdC; dihydrolipoyl dehydrogenase BkdC [KO:K00382] [EC:1.8.1.4]
PP4_52650  gcvH; glycine cleavage system H-protein [KO:K02437]
PP4_31300  gcvH; glycine cleavage system H-protein [KO:K02437]
PP4_43210  gcvH; glycine cleavage system H-protein [KO:K02437]
PP4_21260  creatinase [KO:K08688] [EC:3.5.3.3]
PP4_21290  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
PP4_46550  putative phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
PP4_51270  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
PP4_36560  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
PP4_31340  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
PP4_51260  betB; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
PP4_45650  putative aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
PP4_03420  gbcA; glycine betaine catabolism protein GbcA [KO:K00479] [EC:1.14.13.251]
PP4_03430  gbcB; glycine betaine catabolism protein GbcB [KO:K21832] [EC:1.14.13.251]
PP4_03370  dgcA; dimethylglycine catabolism protein DgcA [KO:K21833] [EC:1.5.7.3]
PP4_03380  dgcB; dimethylglycine catabolism protein DgcB [KO:K21834]
PP4_03390  putative electron transfer flavoprotein alpha subunit [KO:K25960]
PP4_03400  putative electron transfer flavoprotein beta subunit [KO:K25961]
PP4_03520  soxA; sarcosine oxidase alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]
PP4_19920  soxA; sarcosine oxidase alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]
PP4_03500  soxB; sarcosine oxidase beta subunit [KO:K00303] [EC:1.5.3.24 1.5.3.1]
PP4_19940  soxB; sarcosine oxidase beta subunit [KO:K00303] [EC:1.5.3.24 1.5.3.1]
PP4_03530  soxG; sarcosine oxidase gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
PP4_19910  soxG; sarcosine oxidase gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
PP4_03510  soxD; sarcosine oxidase delta subunit [KO:K00304] [EC:1.5.3.24 1.5.3.1]
PP4_19930  soxD; sarcosine oxidase delta subunit [KO:K00304] [EC:1.5.3.24 1.5.3.1]
PP4_12060  putative cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
PP4_03230  sdaA; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
PP4_25160  sdaA; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
PP4_43230  sdaA; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
PP4_25680  putative threonine dehydratase [KO:K01754] [EC:4.3.1.19]
PP4_24110  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
PP4_52140  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
PP4_28790  putative threonine dehydratase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
PP4_31520  dsdA; D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
PP4_21000  alr; putative alanine racemase [KO:K25317] [EC:5.1.1.10]
PP4_00740  trpA; tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
PP4_00750  trpB; tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
PP4_15410  pvdH; diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ppun00010  Glycolysis / Gluconeogenesis
ppun00020  Citrate cycle (TCA cycle)
ppun00230  Purine metabolism
ppun00250  Alanine, aspartate and glutamate metabolism
ppun00270  Cysteine and methionine metabolism
ppun00290  Valine, leucine and isoleucine biosynthesis
ppun00300  Lysine biosynthesis
ppun00330  Arginine and proline metabolism
ppun00460  Cyanoamino acid metabolism
ppun00470  D-Amino acid metabolism
ppun00564  Glycerophospholipid metabolism
ppun00620  Pyruvate metabolism
ppun00630  Glyoxylate and dicarboxylate metabolism
ppun00640  Propanoate metabolism
ppun00680  Methane metabolism
ppun00860  Porphyrin metabolism
ppun00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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