KEGG   PATHWAY: pspa00983
Entry
pspa00983                   Pathway                                
Name
Drug metabolism - other enzymes - Polyodon spathula (Mississippi paddlefish)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
pspa00983  Drug metabolism - other enzymes
pspa00983

Organism
Polyodon spathula (Mississippi paddlefish) [GN:pspa]
Gene
121295670  hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
121296607  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
121326206  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
121318876  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
121298345  impdh2; inosine-5'-monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
121309281  inosine-5'-monophosphate dehydrogenase 2-like [KO:K00088] [EC:1.1.1.205]
121318183  inosine-5'-monophosphate dehydrogenase 1b-like isoform X1 [KO:K00088] [EC:1.1.1.205]
121319901  inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
121327395  GMP synthase [glutamine-hydrolyzing]-like isoform X1 [KO:K01951] [EC:6.3.5.2]
121323248  GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
121314816  probable thiopurine S-methyltransferase isoform X1 [KO:K00569] [EC:2.1.1.67]
121315990  xdh; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
121330470  itpa; inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
121322356  UDP-glucuronosyltransferase 1-6-like [KO:K00699] [EC:2.4.1.17]
121303270  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
121323076  UDP-glucuronosyltransferase 1-2-like [KO:K00699] [EC:2.4.1.17]
121310710  UDP-glucuronosyltransferase 2B10-like [KO:K00699] [EC:2.4.1.17]
121329293  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
121311957  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
121319346  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
121305567  UDP-glucuronosyltransferase 1-2-like [KO:K00699] [EC:2.4.1.17]
121308567  gusb; beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
121328253  cytidine deaminase-like isoform X1 [KO:K01489] [EC:3.5.4.5]
121329387  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
121319931  thymidine phosphorylase [KO:K00758] [EC:2.4.2.4]
121330800  dihydropyrimidine dehydrogenase [NADP(+)]-like isoform X1 [KO:K00207] [EC:1.3.1.2]
121313260  dpys; dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
121307705  upb1; beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
121323503  uridine phosphorylase 2-like [KO:K00757] [EC:2.4.2.3]
121313197  uridine phosphorylase 1-like isoform X1 [KO:K00757] [EC:2.4.2.3]
121313990  uridine phosphorylase 1-like [KO:K00757] [EC:2.4.2.3]
121298275  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
121294116  uridine-cytidine kinase 2-A-like isoform X1 [KO:K00876] [EC:2.7.1.48]
121315557  si:ch211-243j20.2; uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
121326914  uridine-cytidine kinase 2-A isoform X1 [KO:K00876] [EC:2.7.1.48]
121309697  uck1; uridine-cytidine kinase 1 [KO:K00876] [EC:2.7.1.48]
121319313  uckl1b; uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
121295293  thymidine kinase, cytosolic-like [KO:K00857] [EC:2.7.1.21]
121296325  tk2; thymidine kinase 2, mitochondrial isoform X1 [KO:K00857] [EC:2.7.1.21]
121296406  thymidine kinase, cytosolic-like [KO:K00857] [EC:2.7.1.21]
121322627  umps; uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
121327187  UMP-CMP kinase-like [KO:K13800] [EC:2.7.4.14]
121331256  UMP-CMP kinase-like [KO:K13800] [EC:2.7.4.14]
121302884  rrm1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
121314935  rrm2b; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
121315396  ribonucleoside-diphosphate reductase subunit M2-like [KO:K10808] [EC:1.17.4.1]
121308376  ribonucleoside-diphosphate reductase subunit M2 isoform X1 [KO:K10808] [EC:1.17.4.1]
121317530  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
121300880  nme3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
121295623  nucleoside diphosphate kinase A-like [KO:K00940] [EC:2.7.4.6]
121295624  nucleoside diphosphate kinase A 2-like [KO:K00940] [EC:2.7.4.6]
121296075  nucleoside diphosphate kinase A-like [KO:K00940] [EC:2.7.4.6]
121296076  nucleoside diphosphate kinase A 2 [KO:K00940] [EC:2.7.4.6]
121320577  nucleoside diphosphate kinase 7-like isoform X1 [KO:K00940] [EC:2.7.4.6]
121327756  nucleoside diphosphate kinase 7-like isoform X1 [KO:K00940] [EC:2.7.4.6]
121317359  nme6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
121331028  nme4; nucleoside diphosphate kinase, mitochondrial isoform X1 [KO:K00940] [EC:2.7.4.6]
121294840  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like isoform X1 [KO:K01520] [EC:3.6.1.23]
121298773  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
121320378  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like [KO:K01520] [EC:3.6.1.23]
121303039  mpx; eosinophil peroxidase [KO:K10789] [EC:1.11.2.2]
121296609  arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like [KO:K00622] [EC:2.3.1.5]
121325857  arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like [KO:K00622] [EC:2.3.1.5]
121296855  gstt2; glutathione S-transferase theta-2 [KO:K00799] [EC:2.5.1.18]
121296868  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
121299850  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
121300060  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
121325689  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
121314770  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
121326790  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
121315758  gsta.1; glutathione S-transferase, alpha tandem duplicate 1 [KO:K00799] [EC:2.5.1.18]
121308335  mgst3b; microsomal glutathione S-transferase 3b [KO:K00799] [EC:2.5.1.18]
121321723  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
121316861  glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
121312872  glutathione S-transferase A-like isoform X1 [KO:K00799] [EC:2.5.1.18]
121318546  mgst1.1; microsomal glutathione S-transferase 1.1 [KO:K00799] [EC:2.5.1.18]
121330487  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
121325171  mgst2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
121294719  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121323500  gstp1; glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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