KEGG   PATHWAY: qsu03440
Entry
qsu03440                    Pathway                                
Name
Homologous recombination - Quercus suber (cork oak)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
qsu03440  Homologous recombination
qsu03440

Other DBs
GO: 0000724
Organism
Quercus suber (cork oak) [GN:qsu]
Gene
111996966  single-stranded DNA-binding protein, mitochondrial [KO:K03111]
111991818  single-stranded DNA-binding protein, mitochondrial-like [KO:K03111]
112027455  DNA repair protein recA homolog 1, chloroplastic [KO:K03553]
112025962  DNA repair protein recA homolog 3, mitochondrial isoform X1 [KO:K03553]
111998879  DNA polymerase I A, chloroplastic/mitochondrial-like [KO:K02335] [EC:2.7.7.7]
112038484  ATP-dependent DNA helicase homolog RECG, chloroplastic-like isoform X1 [KO:K03655] [EC:5.6.2.4]
112022249  ATP-dependent DNA helicase homolog RECG, chloroplastic-like [KO:K03655] [EC:5.6.2.4]
112022273  ATP-dependent DNA helicase homolog RECG, chloroplastic-like [KO:K03655] [EC:5.6.2.4]
111984229  double-strand break repair protein MRE11 isoform X1 [KO:K10865]
112012926  nijmegen breakage syndrome 1 protein isoform X1 [KO:K10867]
112019333  serine/threonine-protein kinase ATM-like [KO:K04728] [EC:2.7.11.1]
112005203  protein BREAST CANCER SUSCEPTIBILITY 1 homolog [KO:K10683]
112041012  protein BREAST CANCER SUSCEPTIBILITY 1 homolog [KO:K10683]
112007387  BRCA1-associated RING domain protein 1 [KO:K10683]
112023586  Fanconi anemia group J protein homolog [KO:K15362] [EC:5.6.2.3]
111999234  DNA topoisomerase 2-binding protein 1-A isoform X1 [KO:K10728]
112006859  BRCT domain-containing protein At4g02110 isoform X1 [KO:K10728]
111986988  uncharacterized protein LOC111986988 [KO:K20776]
111983228  BRISC and BRCA1-A complex member 2 [KO:K12173]
111983935  lys-63-specific deubiquitinase BRCC36-like [KO:K11864] [EC:3.4.19.-]
111988228  protein BREAST CANCER SUSCEPTIBILITY 2 homolog B-like [KO:K08775]
112029370  protein DSS1 HOMOLOG ON CHROMOSOME V-like [KO:K10881]
112032605  protein DSS1 HOMOLOG ON CHROMOSOME V-like [KO:K10881]
112023528  replication protein A 70 kDa DNA-binding subunit A [KO:K07466]
112020147  replication protein A 70 kDa DNA-binding subunit A-like [KO:K07466]
112017680  replication protein A 70 kDa DNA-binding subunit B [KO:K07466]
112017407  replication protein A 32 kDa subunit A-like [KO:K10739]
112025316  replication protein A 32 kDa subunit B-like [KO:K10739]
112010841  replication protein A 14 kDa subunit B-like [KO:K10740]
112025387  replication protein A 14 kDa subunit B-like [KO:K10740]
112019939  DNA repair protein RAD51 homolog [KO:K04482]
111994240  DNA repair protein RAD51 homolog 2 isoform X1 [KO:K10869]
112016681  DNA repair protein RAD51 homolog 3 [KO:K10870]
111994448  DNA repair protein RAD51 homolog 4 isoform X1 [KO:K10871]
112020890  DNA repair protein XRCC2 homolog isoform X1 [KO:K10879]
112020891  DNA repair protein XRCC2 homolog [KO:K10879]
112025339  DNA repair protein XRCC3 homolog [KO:K10880]
112025342  DNA repair protein XRCC3 homolog [KO:K10880]
112011739  SNF2 domain-containing protein CLASSY 3-like [KO:K10875] [EC:5.6.2.-]
112017743  SNF2 domain-containing protein CLASSY 1-like [KO:K10875] [EC:5.6.2.-]
112000670  SNF2 domain-containing protein CLASSY 4-like [KO:K10875] [EC:5.6.2.-]
112002935  SNF2 domain-containing protein CLASSY 4-like [KO:K10875] [EC:5.6.2.-]
111986518  SNF2 domain-containing protein CLASSY 3-like [KO:K10875] [EC:5.6.2.-]
112032205  protein CHROMATIN REMODELING 35-like [KO:K10875] [EC:5.6.2.-]
112032208  protein CHROMATIN REMODELING 35-like [KO:K10875] [EC:5.6.2.-]
112032212  protein CHROMATIN REMODELING 35-like isoform X1 [KO:K10875] [EC:5.6.2.-]
112024447  protein CHROMATIN REMODELING 25 [KO:K10875] [EC:5.6.2.-]
112011411  DNA polymerase delta catalytic subunit isoform X1 [KO:K02327] [EC:2.7.7.7]
112015495  DNA polymerase delta small subunit [KO:K02328]
112021016  DNA polymerase delta subunit 3 [KO:K03504]
111988029  DNA polymerase delta subunit 4-like [KO:K03505]
111997209  DNA polymerase delta subunit 4-like [KO:K03505]
112008948  ATP-dependent DNA helicase Q-like 4A [KO:K10901] [EC:5.6.2.4]
111996696  ATP-dependent DNA helicase Q-like 3 isoform X1 [KO:K10901] [EC:5.6.2.4]
112029290  DNA topoisomerase 3-alpha isoform X1 [KO:K03165] [EC:5.6.2.1]
112035825  DNA topoisomerase 3-beta isoform X1 [KO:K03165] [EC:5.6.2.1]
111988953  crossover junction endonuclease MUS81-like [KO:K08991] [EC:3.1.22.-]
112030433  crossover junction endonuclease MUS81 isoform X1 [KO:K08991] [EC:3.1.22.-]
111991624  crossover junction endonuclease EME1B-like isoform X1 [KO:K10882] [EC:3.1.22.-]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   
LinkDB

DBGET integrated database retrieval system