KEGG   PATHWAY: ray04814
Entry
ray04814                    Pathway                                
Name
Motor proteins - Rousettus aegyptiacus (Egyptian rousette)
Class
Cellular Processes; Cell motility
Pathway map
ray04814  Motor proteins
ray04814

Organism
Rousettus aegyptiacus (Egyptian rousette) [GN:ray]
Gene
107521376  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 isoform X1 [KO:K10413]
107520205  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
107503329  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
107499568  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
107508781  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
107519818  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
107509581  DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 isoform X1 [KO:K10417]
107503033  DYNLL2; dynein light chain 2, cytoplasmic [KO:K10418]
107501252  DYNLL1; dynein light chain 1, cytoplasmic [KO:K10418]
107519485  DYNLRB1; dynein light chain roadblock-type 1 [KO:K10419]
107521332  DYNLRB2; dynein light chain roadblock-type 2 [KO:K10419]
107503932  DYNLT3; dynein light chain Tctex-type 3 [KO:K10420]
107514718  DYNLT1; dynein light chain Tctex-type 1 isoform X1 [KO:K10420]
107500160  TCTE3; tctex1 domain-containing protein 3 [KO:K25419]
107499394  TCTEX1D4; tctex1 domain-containing protein 4 [KO:K25420]
107498153  TCTEX1D1; tctex1 domain-containing protein 1 [KO:K25421]
107503393  DNAH12; dynein heavy chain 12, axonemal isoform X1 [KO:K10408]
107504601  DNAH10; LOW QUALITY PROTEIN: dynein heavy chain 10, axonemal [KO:K10408]
107498566  DNAH1; dynein heavy chain 1, axonemal isoform X1 [KO:K10408]
107506355  DNAH6; LOW QUALITY PROTEIN: dynein heavy chain 6, axonemal [KO:K10408]
107514440  DNAH5; LOW QUALITY PROTEIN: dynein heavy chain 5, axonemal [KO:K10408]
107515685  DNAH2; dynein heavy chain 2, axonemal isoform X1 [KO:K10408]
107515695  LOW QUALITY PROTEIN: dynein heavy chain 8, axonemal-like [KO:K10408]
107508404  DNAH7; LOW QUALITY PROTEIN: dynein heavy chain 7, axonemal [KO:K10408]
107510065  DNAH17; LOW QUALITY PROTEIN: dynein heavy chain 17, axonemal [KO:K10408]
107518131  DNAH11; dynein heavy chain 11, axonemal isoform X1 [KO:K10408]
107515470  dynein heavy chain 8, axonemal isoform X1 [KO:K10408]
107517402  DNAH9; dynein heavy chain 9, axonemal isoform X1 [KO:K10408]
107516076  DNAH3; dynein heavy chain 3, axonemal [KO:K10408]
107521068  DNAH14; LOW QUALITY PROTEIN: dynein heavy chain 14, axonemal [KO:K10408]
107502815  DNAI1; dynein intermediate chain 1, axonemal [KO:K10409]
107510260  DNAI2; LOW QUALITY PROTEIN: dynein intermediate chain 2, axonemal [KO:K11143]
107511569  WDR63; LOW QUALITY PROTEIN: WD repeat-containing protein 63 [KO:K24722]
107498147  WDR78; LOW QUALITY PROTEIN: WD repeat-containing protein 78 [KO:K24723]
107517072  DNALI1; LOW QUALITY PROTEIN: axonemal dynein light intermediate polypeptide 1 [KO:K10410]
107505020  DNAL1; dynein light chain 1, axonemal [KO:K10411]
107519300  DNAL4; dynein light chain 4, axonemal isoform X1 [KO:K10412]
107502898  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
107501501  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
107502859  DCTN3; dynactin subunit 3 [KO:K10425]
107497166  DCTN4; dynactin subunit 4 isoform X1 [KO:K10426]
107516090  DCTN5; dynactin subunit 5 [KO:K10427]
107505788  DCTN6; dynactin subunit 6 [KO:K10428]
107515575  ACTR1A; alpha-centractin [KO:K16575]
107509969  ACTR1B; beta-centractin isoform X1 [KO:K16575]
107502129  ACTR10; actin-related protein 10 isoform X1 [KO:K16576]
107499674  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
107499804  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
107497467  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
107501791  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
107501239  CCDC64; bicaudal D-related protein 1 isoform X1 [KO:K16756]
107498772  CCDC64B; bicaudal D-related protein 2 isoform X1 [KO:K16756]
107501350  HOOK3; protein Hook homolog 3 [KO:K16536]
107516782  tubulin alpha-1B chain-like [KO:K07374]
107500328  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
107497847  LOW QUALITY PROTEIN: tubulin alpha-3 chain-like [KO:K07374]
107497857  tubulin alpha-3 chain-like [KO:K07374]
107514242  tubulin alpha-1A chain isoform X1 [KO:K07374]
107514243  tubulin alpha-1C chain [KO:K07374]
107516732  tubulin alpha-4A chain isoform X1 [KO:K07374]
107502098  tubulin beta-3 chain [KO:K07375]
107503105  TUBB4B; LOW QUALITY PROTEIN: tubulin beta-4B chain [KO:K07375]
107511148  TUBB4A; tubulin beta-4A chain [KO:K07375]
107521721  TUBB2A; tubulin beta-2A chain [KO:K07375]
107521722  tubulin beta-2B chain [KO:K07375]
107500090  TUBB1; LOW QUALITY PROTEIN: tubulin beta-1 chain [KO:K07375]
107497724  TUBB6; tubulin beta-6 chain [KO:K07375]
107498082  TUBB; tubulin beta chain [KO:K07375]
107513832  TUBG1; tubulin gamma-1 chain [KO:K10389]
107513833  tubulin gamma-2 chain [KO:K10389]
107510138  TUBD1; tubulin delta chain isoform X1 [KO:K10390]
107506304  TUBE1; tubulin epsilon chain [KO:K10391]
107513931  KIF5C; kinesin heavy chain isoform 5C [KO:K10396]
107518439  KIF5B; kinesin-1 heavy chain [KO:K10396]
107501516  KIF5A; kinesin heavy chain isoform 5A isoform X1 [KO:K10396]
107513627  KLC3; kinesin light chain 3 [KO:K10407]
107497533  KLC2; kinesin light chain 2 [KO:K10407]
107498378  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
107501964  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
107497056  KIF3A; kinesin-like protein KIF3A isoform X1 [KO:K10394]
107512872  KIF3B; kinesin-like protein KIF3B [KO:K20196]
107512767  KIFAP3; kinesin-associated protein 3 isoform X1 [KO:K25388]
107498544  KIF3C; kinesin-like protein KIF3C isoform X1 [KO:K20197]
107513044  KIF17; kinesin-like protein KIF17 isoform X1 [KO:K20198]
107520155  KIF1B; LOW QUALITY PROTEIN: kinesin-like protein KIF1B [KO:K10392]
107509474  KIF1C; kinesin-like protein KIF1C [KO:K10392]
107510575  KIF1A; kinesin-like protein KIF1A isoform X1 [KO:K10392]
107516276  KIF13A; LOW QUALITY PROTEIN: kinesin-like protein KIF13A [KO:K17914]
107510784  KIF13B; LOW QUALITY PROTEIN: kinesin-like protein KIF13B [KO:K17914]
107513624  KIF14; LOW QUALITY PROTEIN: kinesin-like protein KIF14 [KO:K17915]
107498657  KIF16B; kinesin-like protein KIF16B isoform X1 [KO:K17916]
107510934  STARD9; stAR-related lipid transfer protein 9 isoform X1 [KO:K16491]
107503833  KIF4A; chromosome-associated kinesin KIF4A isoform X1 [KO:K10395]
107514148  KIF7; LOW QUALITY PROTEIN: kinesin-like protein KIF7 [KO:K18806]
107514212  KIF21A; kinesin-like protein KIF21A isoform X1 [KO:K24185]
107513646  KIF21B; kinesin-like protein KIF21B isoform X1 [KO:K24185]
107502819  KIF27; LOW QUALITY PROTEIN: kinesin-like protein KIF27 [KO:K24186]
107514008  KIF11; kinesin-like protein KIF11 [KO:K10398]
107518723  KIF20A; kinesin-like protein KIF20A [KO:K10402]
107501617  KIF20B; kinesin-like protein KIF20B isoform X1 [KO:K10402]
107511429  KIF23; kinesin-like protein KIF23 isoform X1 [KO:K17387]
107517918  CENPE; centromere-associated protein E isoform X1 [KO:K11498]
107512169  kinesin-like protein KIF18A [KO:K10401]
107499116  kinesin-like protein KIF18A isoform X1 [KO:K10401]
107508156  KIF18B; kinesin-like protein KIF18B [KO:K26156]
107510258  KIF19; kinesin-like protein KIF19 isoform X1 [KO:K26157]
107497363  kinesin-like protein KIF19 [KO:K26157]
107509114  KIF9; LOW QUALITY PROTEIN: kinesin-like protein KIF9 [KO:K10397]
107515463  KIF6; LOW QUALITY PROTEIN: kinesin-like protein KIF6 [KO:K10397]
107515869  KIF22; kinesin-like protein KIF22 isoform X1 [KO:K10403]
107521494  LOW QUALITY PROTEIN: kinesin-like protein KIF26B [KO:K10404]
107498369  KIF26A; LOW QUALITY PROTEIN: kinesin-like protein KIF26A [KO:K10404]
107500762  KIF12; kinesin-like protein KIF12 isoform X1 [KO:K10399]
107509076  KIF15; kinesin-like protein KIF15 isoform X1 [KO:K10400]
107502794  KIF24; kinesin-like protein KIF24 [KO:K10393]
107506362  KIF2A; kinesin-like protein KIF2A isoform X1 [KO:K10393]
107515881  KIF2B; kinesin-like protein KIF2B [KO:K10393]
107499391  KIF2C; kinesin-like protein KIF2C isoform X1 [KO:K10393]
107511974  KIFC1; kinesin-like protein KIFC1 isoform X1 [KO:K10405]
107513991  KIFC3; kinesin-like protein KIFC3 isoform X1 [KO:K10406]
107503506  KIFC2; LOW QUALITY PROTEIN: kinesin-like protein KIFC2 [KO:K10406]
107521268  MYO1A; unconventional myosin-Ia [KO:K10356]
107519901  MYO1F; unconventional myosin-If [KO:K10356]
107507725  MYO1C; unconventional myosin-Ic isoform X1 [KO:K10356]
107512399  MYO1G; LOW QUALITY PROTEIN: unconventional myosin-Ig [KO:K10356]
107501056  MYO1E; unconventional myosin-Ie [KO:K10356]
107500127  MYO1H; unconventional myosin-Ih isoform X1 [KO:K10356]
107514211  unconventional myosin-Ib isoform X1 [KO:K10356]
107514643  MYO1D; unconventional myosin-Id isoform X1 [KO:K10356]
107500097  MYO3A; myosin-IIIa isoform X1 [KO:K08834] [EC:2.7.11.1]
107521059  MYO3B; myosin-IIIb isoform X1 [KO:K08834] [EC:2.7.11.1]
107515157  unconventional myosin-Va isoform X1 [KO:K10357]
107519726  MYO5C; unconventional myosin-Vc isoform X1 [KO:K10357]
107520740  MYO5B; unconventional myosin-Vb isoform X1 [KO:K10357]
107509291  MYO6; unconventional myosin-VI isoform X1 [KO:K10358]
107519181  MYO7A; unconventional myosin-VIIa isoform X1 [KO:K10359]
107516876  MYO7B; unconventional myosin-VIIb isoform X1 [KO:K21868]
107501071  MYO9A; unconventional myosin-IXa isoform X1 [KO:K10360]
107517226  MYO9B; unconventional myosin-IXb isoform X1 [KO:K10360]
107497287  MYO10; unconventional myosin-X isoform X1 [KO:K12559]
107511088  MYO15A; unconventional myosin-XV [KO:K10361]
107502241  unconventional myosin-XV-like [KO:K10361]
107511111  MYO16; unconventional myosin-XVI isoform X1 [KO:K17481]
107499747  MYO18B; LOW QUALITY PROTEIN: unconventional myosin-XVIIIb [KO:K10362]
107507763  MYO18A; unconventional myosin-XVIIIa isoform X1 [KO:K10362]
107510117  MYO19; unconventional myosin-XIX isoform X1 [KO:K25838]
107498316  MYH1; LOW QUALITY PROTEIN: myosin-1 [KO:K24220]
107498310  LOW QUALITY PROTEIN: myosin-8-like [KO:K24220]
107498317  myosin-2 [KO:K24220]
107498311  myosin-3 [KO:K24220]
107500785  MYH7B; myosin-7B isoform X1 [KO:K24220]
107519612  MYH15; LOW QUALITY PROTEIN: myosin-15 [KO:K24220]
107498315  MYH4; myosin-4 [KO:K24220]
107498314  MYH13; myosin-13 [KO:K24220]
107498010  MYH6; myosin-6 [KO:K17751]
107498011  myosin-7 [KO:K17751]
107500388  MYH14; LOW QUALITY PROTEIN: myosin-14 [KO:K10352]
107515660  MYH10; myosin-10 isoform X1 [KO:K10352]
107516819  MYH11; myosin-11 isoform X1 [KO:K10352]
107519230  MYH9; myosin-9 [KO:K10352]
107517638  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
107509109  MYL3; myosin light chain 3 [KO:K12749]
107508180  MYL4; myosin light chain 4 isoform X1 [KO:K12750]
107521249  MYL6; myosin light polypeptide 6 isoform X1 [KO:K12751]
107521248  MYL6B; myosin light chain 6B [KO:K12751]
107513248  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
107518021  MYL5; myosin light chain 5 isoform X1 [KO:K12753]
107512384  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
107512613  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
107511757  MYL10; LOW QUALITY PROTEIN: myosin regulatory light chain 10 [KO:K12756]
107516865  myosin regulatory light polypeptide 9 isoform X1 [KO:K12757]
107516877  myosin regulatory light chain 12B [KO:K12757]
107515867  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
107520075  ACTA1; LOW QUALITY PROTEIN: actin, alpha skeletal muscle [KO:K10354]
107502214  ACTA2; actin, aortic smooth muscle [KO:K12313]
107508080  ACTC1; actin, alpha cardiac muscle 1 [KO:K12314]
107502939  ACTG2; actin, gamma-enteric smooth muscle [KO:K12315]
107520262  ACTG1; actin, cytoplasmic 2 [KO:K05692]
107515934  ACTB; actin, cytoplasmic 1 [KO:K05692]
107498574  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
107513654  TNNI1; troponin I, slow skeletal muscle [KO:K10371]
107515440  TNNT1; troponin T, slow skeletal muscle isoform X1 [KO:K10372]
107514546  TNNC2; troponin C, skeletal muscle [KO:K12042]
107513290  TNNI2; LOW QUALITY PROTEIN: troponin I, fast skeletal muscle [KO:K12043]
107513237  TNNT3; LOW QUALITY PROTEIN: troponin T, fast skeletal muscle [KO:K12046]
107515439  TNNI3; troponin I, cardiac muscle [KO:K12044]
107513651  TNNT2; troponin T, cardiac muscle isoform X1 [KO:K12045]
107508997  TPM1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
107502868  TPM2; tropomyosin beta chain isoform X1 [KO:K10374]
107509189  TPM3; tropomyosin alpha-3 chain isoform X1 [KO:K09290]
107517241  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
Reference
PMID:21092854
  Authors
Hirokawa N, Niwa S, Tanaka Y
  Title
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease.
  Journal
Neuron 68:610-38 (2010)
DOI:10.1016/j.neuron.2010.09.039
Reference
PMID:25470043 (PDB:4RH7)
  Authors
Schmidt H, Zalyte R, Urnavicius L, Carter AP
  Title
Structure of human cytoplasmic dynein-2 primed for its power stroke.
  Journal
Nature 518:435-438 (2015)
DOI:10.1038/nature14023
Reference
PMID:22398446 (PDB:3VKG 3VKH)
  Authors
Kon T, Oyama T, Shimo-Kon R, Imamula K, Shima T, Sutoh K, Kurisu G
  Title
The 2.8 A crystal structure of the dynein motor domain.
  Journal
Nature 484:345-50 (2012)
DOI:10.1038/nature10955
Reference
PMID:22997337 (PDB:3J1T 3J1U)
  Authors
Redwine WB, Hernandez-Lopez R, Zou S, Huang J, Reck-Peterson SL, Leschziner AE
  Title
Structural basis for microtubule binding and release by dynein.
  Journal
Science 337:1532-1536 (2012)
DOI:10.1126/science.1224151
Reference
PMID:26410600
  Authors
Gibbs KL, Greensmith L, Schiavo G
  Title
Regulation of Axonal Transport by Protein Kinases.
  Journal
Trends Biochem Sci 40:597-610 (2015)
DOI:10.1016/j.tibs.2015.08.003
Reference
PMID:28602352 (PDB:5NUG 5NVS 5NVU 5NW4)
  Authors
Zhang K, Foster HE, Rondelet A, Lacey SE, Bahi-Buisson N, Bird AW, Carter AP
  Title
Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated.
  Journal
Cell 169:1303-1314.e18 (2017)
DOI:10.1016/j.cell.2017.05.025
Reference
PMID:25814576 (PDB:5ADX 5AFR 5AFU)
  Authors
Urnavicius L, Zhang K, Diamant AG, Motz C, Schlager MA, Yu M, Patel NA, Robinson CV, Carter AP
  Title
The structure of the dynactin complex and its interaction with dynein.
  Journal
Science 347:1441-1446 (2015)
DOI:10.1126/science.aaa4080
Reference
PMID:29420470 (PDB:5OWO 6F1T 6F1U 6F1V 6F1Y 6F1Z 6F38 6F3A)
  Authors
Urnavicius L, Lau CK, Elshenawy MM, Morales-Rios E, Motz C, Yildiz A, Carter AP
  Title
Cryo-EM shows how dynactin recruits two dyneins for faster movement.
  Journal
Nature 554:202-206 (2018)
DOI:10.1038/nature25462
Reference
PMID:29662141
  Authors
Reck-Peterson SL, Redwine WB, Vale RD, Carter AP
  Title
The cytoplasmic dynein transport machinery and its many cargoes.
  Journal
Nat Rev Mol Cell Biol 19:382-398 (2018)
DOI:10.1038/s41580-018-0004-3
Reference
PMID:23434508 (PDB:3J2U)
  Authors
Asenjo AB, Chatterjee C, Tan D, DePaoli V, Rice WJ, Diaz-Avalos R, Silvestry M, Sosa H
  Title
Structural model for tubulin recognition and deformation by kinesin-13 microtubule depolymerases.
  Journal
Cell Rep 3:759-68 (2013)
DOI:10.1016/j.celrep.2013.01.030
Reference
PMID:10338210 (PDB:1B7T)
  Authors
Houdusse A, Kalabokis VN, Himmel D, Szent-Gyorgyi AG, Cohen C
  Title
Atomic structure of scallop myosin subfragment S1 complexed with MgADP: a novel conformation of the myosin head.
  Journal
Cell 97:459-70 (1999)
DOI:10.1016/s0092-8674(00)80756-4
Reference
PMID:9428521 (PDB:3KIN)
  Authors
Kozielski F, Sack S, Marx A, Thormahlen M, Schonbrunn E, Biou V, Thompson A, Mandelkow EM, Mandelkow E
  Title
The crystal structure of dimeric kinesin and implications for microtubule-dependent motility.
  Journal
Cell 91:985-94 (1997)
DOI:10.1016/s0092-8674(00)80489-4
Reference
PMID:8316857 (PDB:2MYS)
  Authors
Rayment I, Rypniewski WR, Schmidt-Base K, Smith R, Tomchick DR, Benning MM, Winkelmann DA, Wesenberg G, Holden HM
  Title
Three-dimensional structure of myosin subfragment-1: a molecular motor.
  Journal
Science 261:50-8 (1993)
DOI:10.1126/science.8316857
Reference
PMID:20428469
  Authors
Parker D, Bryant Z, Delp SL
  Title
Coarse-Grained Structural Modeling of Molecular Motors Using Multibody Dynamics.
  Journal
Cell Mol Bioeng 2:366-374 (2009)
DOI:10.1007/s12195-009-0084-4
Reference
PMID:21314430
  Authors
Dominguez R, Holmes KC
  Title
Actin structure and function.
  Journal
Annu Rev Biophys 40:169-86 (2011)
DOI:10.1146/annurev-biophys-042910-155359
Reference
PMID:31919429 (PDB:6KN7 6KN8)
  Authors
Yamada Y, Namba K, Fujii T
  Title
Cardiac muscle thin filament structures reveal calcium regulatory mechanism.
  Journal
Nat Commun 11:153 (2020)
DOI:10.1038/s41467-019-14008-1
Reference
PMID:33912943
  Authors
Kruppa AJ, Buss F
  Title
Motor proteins at the mitochondria-cytoskeleton interface.
  Journal
J Cell Sci 134:239092 (2021)
DOI:10.1242/jcs.226084
KO pathway
ko04814   
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