Entry
Name
Melanogenesis - Rousettus aegyptiacus (Egyptian rousette)
Description
Cutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory control by multiple agents. The most important positive regulator of melanogenesis is the MC1 receptor with its ligands melanocortic peptides. MC1R activates the cyclic AMP (cAMP) response-element binding protein (CREB). Increased expression of MITF and its activation by phosphorylation (P) stimulate the transcription of tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), and dopachrome tautomerase (DCT), which produce melanin. Melanin synthesis takes place within specialized intracellular organelles named melanosomes. Melanin-containing melanosomes then move from the perinuclear region to the dendrite tips and are transferred to keratinocytes by a still not well-characterized mechanism.
Class
Organismal Systems; Endocrine system
BRITE hierarchy
Pathway map
Ortholog table
Organism
Rousettus aegyptiacus (Egyptian rousette) [GN:
ray ]
Gene
107500067 GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632 ]
107505169 CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870 ]
107509179 CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048 ]
107502779 CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048 ]
107511864 CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048 ]
107510647 CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048 ]
107499057 CREB3L2; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048 ]
107509178 MITF; microphthalmia-associated transcription factor isoform X1 [KO:K09455 ]
107499654 GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534 ]
107517194 GNAQ; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634 ]
107507013 DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353 ]
107509513 DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353 ]
107510646 DVL1; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-1 [KO:K02353 ]
107519850 TYRP1; LOW QUALITY PROTEIN: 5,6-dihydroxyindole-2-carboxylic acid oxidase [KO:K00506 ] [EC:1.14.18.-]
107516134 GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630 ]
107518173 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
107513376 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
107506114 PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
107519930 PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
107497081 PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
107514464 PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
107510894 CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
107512385 CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
107497167 CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
107498266 CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference
Authors
Slominski A, Tobin DJ, Shibahara S, Wortsman J.
Title
Melanin pigmentation in mammalian skin and its hormonal regulation.
Journal
Reference
Authors
Busca R, Ballotti R.
Title
Cyclic AMP a key messenger in the regulation of skin pigmentation.
Journal
Reference
Authors
Imokawa G.
Title
Autocrine and paracrine regulation of melanocytes in human skin and in pigmentary disorders.
Journal
Reference
Authors
Wikberg JE, Muceniece R, Mandrika I, Prusis P, Lindblom J, Post C, Skottner A.
Title
New aspects on the melanocortins and their receptors.
Journal
Reference
Authors
Chin L.
Title
The genetics of malignant melanoma: lessons from mouse and man.
Journal
Reference
Authors
Miller AJ, Mihm MC Jr.
Title
Melanoma.
Journal
Reference
Authors
Saito H, Yasumoto K, Takeda K, Takahashi K, Yamamoto H, Shibahara S.
Title
Microphthalmia-associated transcription factor in the Wnt signaling pathway.
Journal
Reference
Authors
Imokawa G, Kobayashi T, Miyagishi M, Higashi K, Yada Y.
Title
The role of endothelin-1 in epidermal hyperpigmentation and signaling mechanisms of mitogenesis and melanogenesis.
Journal
Reference
Authors
Park HY, Gilchrest BA.
Title
Signaling pathways mediating melanogenesis.
Journal
Cell Mol Biol (Noisy-le-grand) 45:919-30 (1999)
Reference
Authors
Park HY, Perez JM, Laursen R, Hara M, Gilchrest BA.
Title
Protein kinase C-beta activates tyrosinase by phosphorylating serine residues in its cytoplasmic domain.
Journal
Reference
Authors
Sturm RA, Teasdale RD, Box NF.
Title
Human pigmentation genes: identification, structure and consequences of polymorphic variation.
Journal
Reference
Authors
Hearing VJ.
Title
The melanosome: the perfect model for cellular responses to the environment.
Journal
Reference
Authors
Molina DM, Grewal S, Bardwell L.
Title
Characterization of an ERK-binding domain in microphthalmia-associated transcription factor and differential inhibition of ERK2-mediated substrate phosphorylation.
Journal
Related pathway
KO pathway
LinkDB
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