KEGG   PATHWAY: rlu00260
Entry
rlu00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Rhizobium leguminosarum bv. trifolii CB782
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
rlu00260  Glycine, serine and threonine metabolism
rlu00260

Module
rlu_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:rlu00260]
rlu_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:rlu00260]
rlu_M00555  Betaine biosynthesis, choline => betaine [PATH:rlu00260]
rlu_M00621  Glycine cleavage system [PATH:rlu00260]
rlu_M00919  Ectoine degradation, ectoine => aspartate [PATH:rlu00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Rhizobium leguminosarum bv. trifolii CB782 [GN:rlu]
Gene
RLEG12_29060  aspartate kinase [KO:K00928] [EC:2.7.2.4]
RLEG12_31125  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
RLEG12_19185  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
RLEG12_09690  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
RLEG12_09670  homoserine kinase [KO:K02204] [EC:2.7.1.39]
RLEG12_14385  homoserine kinase [KO:K02204] [EC:2.7.1.39]
RLEG12_14505  threonine synthase [KO:K01733] [EC:4.2.3.1]
RLEG12_09750  threonine aldolase [KO:K01620] [EC:4.1.2.48]
RLEG12_28010  threonine aldolase [KO:K01620] [EC:4.1.2.48]
RLEG12_16930  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
RLEG12_08615  D-2-hydroxyacid dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
RLEG12_32230  2-hydroxyacid dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
RLEG12_05275  D-2-hydroxyacid dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
RLEG12_09655  D-2-hydroxyacid dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
RLEG12_18455  TtuD3 hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
RLEG12_21365  phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
RLEG12_32180  phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
RLEG12_27445  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
RLEG12_11060  dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
RLEG12_27450  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
RLEG12_23805  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
RLEG12_24705  2-amino-3-ketobutyrate CoA ligase [KO:K00639] [EC:2.3.1.29]
RLEG12_24700  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
RLEG12_29565  5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
RLEG12_02080  monoamine oxidase [KO:K00274] [EC:1.4.3.4]
RLEG12_20770  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
RLEG12_20760  aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
RLEG12_01975  aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
RLEG12_02035  aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
RLEG12_05220  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
RLEG12_29810  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
RLEG12_19520  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
RLEG12_20765  glycine cleavage system protein H [KO:K02437]
RLEG12_16475  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
RLEG12_15230  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
RLEG12_10550  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
RLEG12_15235  4-trimethylaminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
RLEG12_14115  Rieske (2Fe-2S) protein [KO:K00479] [EC:1.14.13.251]
RLEG12_10965  (Fe-S)-binding protein [KO:K00479] [EC:1.14.13.251]
RLEG12_10960  FAD/NAD/ferredoxin protein [KO:K21832] [EC:1.14.13.251]
RLEG12_28200  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
RLEG12_28210  sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
RLEG12_28195  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
RLEG12_28205  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
RLEG12_20610  serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
RLEG12_09735  eutB; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
RLEG12_09810  TdcB [KO:K01754] [EC:4.3.1.19]
RLEG12_27850  serine/threonine dehydratase [KO:K01754] [EC:4.3.1.19]
RLEG12_04765  eutB; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
RLEG12_18250  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
RLEG12_31080  serine dehydratase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
RLEG12_05700  amino acid deaminase [KO:K01753] [EC:4.3.1.18]
RLEG12_31385  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
RLEG12_31380  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
RLEG12_14220  ectoine synthase [KO:K06720] [EC:4.2.1.108]
RLEG12_04775  X-Pro dipeptidase [KO:K15783] [EC:3.5.4.44]
RLEG12_04780  deacylase [KO:K15784] [EC:3.5.1.125]
RLEG12_09700  aminotransferase [KO:K15785] [EC:2.6.1.76]
RLEG12_04720  aminotransferase [KO:K15785] [EC:2.6.1.76]
RLEG12_04725  aldehyde dehydrogenase [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
rlu00010  Glycolysis / Gluconeogenesis
rlu00020  Citrate cycle (TCA cycle)
rlu00230  Purine metabolism
rlu00250  Alanine, aspartate and glutamate metabolism
rlu00270  Cysteine and methionine metabolism
rlu00290  Valine, leucine and isoleucine biosynthesis
rlu00300  Lysine biosynthesis
rlu00330  Arginine and proline metabolism
rlu00460  Cyanoamino acid metabolism
rlu00470  D-Amino acid metabolism
rlu00564  Glycerophospholipid metabolism
rlu00600  Sphingolipid metabolism
rlu00620  Pyruvate metabolism
rlu00630  Glyoxylate and dicarboxylate metabolism
rlu00640  Propanoate metabolism
rlu00680  Methane metabolism
rlu00860  Porphyrin metabolism
rlu00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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