KEGG   PATHWAY: rphi00480
Entry
rphi00480                   Pathway                                
Name
Glutathione metabolism - Ruditapes philippinarum (Manila clam)
Class
Metabolism; Metabolism of other amino acids
Pathway map
rphi00480  Glutathione metabolism
rphi00480

Module
rphi_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:rphi00480]
Other DBs
GO: 0006749
Organism
Ruditapes philippinarum (Manila clam) [GN:rphi]
Gene
132734866  glutathione hydrolase 7-like [KO:K00681] [EC:2.3.2.2 3.4.19.13]
132741793  glutathione hydrolase-like YwrD proenzyme [KO:K00681] [EC:2.3.2.2 3.4.19.13]
132732922  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
132737731  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
132738396  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
132727957  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
132727959  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
132729018  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
132717326  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
132715286  gamma-glutamylcyclotransferase-like [KO:K00682] [EC:4.3.2.9]
132723830  putative glutathione-specific gamma-glutamylcyclotransferase 2 [KO:K07232] [EC:4.3.2.7]
132713794  putative glutathione-specific gamma-glutamylcyclotransferase 2 [KO:K07232] [EC:4.3.2.7]
132713795  putative glutathione-specific gamma-glutamylcyclotransferase 2 [KO:K07232] [EC:4.3.2.7]
132715397  5-oxoprolinase-like [KO:K01469] [EC:3.5.2.9]
132757496  glutamate--cysteine ligase catalytic subunit-like [KO:K11204] [EC:6.3.2.2]
132755630  glutamate--cysteine ligase regulatory subunit-like [KO:K11205]
132747858  glutathione synthetase-like [KO:K21456] [EC:6.3.2.3]
132723695  glutathione synthetase-like [KO:K21456] [EC:6.3.2.3]
132731580  glutathione synthetase-like isoform X1 [KO:K21456] [EC:6.3.2.3]
132735553  cytosol aminopeptidase-like [KO:K11142] [EC:3.4.11.1 3.4.11.5]
132749416  putative aminopeptidase W07G4.4 isoform X1 [KO:K01255] [EC:3.4.11.1]
132725179  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
132755792  aminopeptidase Ey-like isoform X1 [KO:K11140] [EC:3.4.11.2]
132713241  aminopeptidase N-like isoform X1 [KO:K11140] [EC:3.4.11.2]
132713457  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
132744589  aminopeptidase N-like isoform X1 [KO:K11140] [EC:3.4.11.2]
132747544  microsomal glutathione S-transferase 2-like [KO:K00799] [EC:2.5.1.18]
132747546  microsomal glutathione S-transferase 2-like [KO:K00799] [EC:2.5.1.18]
132734618  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
132734623  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
132734624  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
132734636  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
132734837  glutathione S-transferase 1-1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
132749096  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
132723386  pyrimidodiazepine synthase-like [KO:K00799] [EC:2.5.1.18]
132736910  microsomal glutathione S-transferase 2-like [KO:K00799] [EC:2.5.1.18]
132751562  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
132738935  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
132753979  probable glutathione S-transferase 7 isoform X1 [KO:K00799] [EC:2.5.1.18]
132726475  pyrimidodiazepine synthase-like isoform X1 [KO:K00799] [EC:2.5.1.18]
132726477  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
132755093  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
132713089  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
132727262  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
132727263  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
132727264  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
132727267  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
132755938  glutathione S-transferase Mu 3-like [KO:K00799] [EC:2.5.1.18]
132755940  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
132755941  glutathione S-transferase Mu 4-like [KO:K00799] [EC:2.5.1.18]
132755942  glutathione S-transferase Mu 4-like [KO:K00799] [EC:2.5.1.18]
132713612  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
132713613  glutathione S-transferase Mu 4-like [KO:K00799] [EC:2.5.1.18]
132756838  glutathione S-transferase 2-like [KO:K00799] [EC:2.5.1.18]
132743480  probable glutathione S-transferase 9 [KO:K00799] [EC:2.5.1.18]
132757180  glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
132757793  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
132729856  glutathione S-transferase class-mu 28 kDa isozyme-like [KO:K00799] [EC:2.5.1.18]
132758687  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
132745077  probable glutathione S-transferase 7 [KO:K00799] [EC:2.5.1.18]
132759988  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
132759990  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
132732263  glutathione S-transferase 3, mitochondrial-like [KO:K00799] [EC:2.5.1.18]
132747129  glutathione S-transferase 3, mitochondrial-like isoform X1 [KO:K00799] [EC:2.5.1.18]
132720216  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
132720217  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
132739157  glutathione S-transferase P 1-like [KO:K23790] [EC:2.5.1.18]
132760502  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
132721786  glutathione S-transferase kappa 1-like [KO:K13299] [EC:2.5.1.18]
132723000  S-crystallin SL11-like isoform X1 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
132724275  probable glutathione S-transferase 9 isoform X1 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
132756837  S-crystallin SL11-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
132743760  uncharacterized protein LOC132743760 isoform X1 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
132736668  glutathione reductase, mitochondrial-like [KO:K00383] [EC:1.8.1.7]
132734268  isocitrate dehydrogenase [NADP] cytoplasmic-like [KO:K00031] [EC:1.1.1.42]
132722469  isocitrate dehydrogenase [NADP], mitochondrial-like [KO:K00031] [EC:1.1.1.42]
132753910  6-phosphogluconate dehydrogenase, decarboxylating-like [KO:K00033] [EC:1.1.1.44 1.1.1.343]
132719941  glucose-6-phosphate 1-dehydrogenase X-like isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
132732954  glucose-6-phosphate 1-dehydrogenase X-like isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
132727301  thioredoxin domain-containing protein 12-like [KO:K05360] [EC:1.8.4.2]
132750097  glutathione peroxidase-like isoform X1 [KO:K05361] [EC:1.11.1.12]
132751933  glutathione peroxidase-like [KO:K00432] [EC:1.11.1.9]
132751934  glutathione peroxidase-like [KO:K00432] [EC:1.11.1.9]
132739433  glutathione peroxidase 2-like [KO:K00432] [EC:1.11.1.9]
132739435  glutathione peroxidase 2-like [KO:K00432] [EC:1.11.1.9]
132730895  glutathione peroxidase 7-like [KO:K00432] [EC:1.11.1.9]
132728259  peroxiredoxin-6-like [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
132757302  peroxiredoxin-6-like [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
132719644  ornithine decarboxylase 1-like [KO:K01581] [EC:4.1.1.17]
132740673  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
132740682  antizyme inhibitor 2-like isoform X1 [KO:K01581] [EC:4.1.1.17]
132755592  LOW QUALITY PROTEIN: ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
132755595  ornithine decarboxylase 1-like [KO:K01581] [EC:4.1.1.17]
132755597  ornithine decarboxylase 1-like [KO:K01581] [EC:4.1.1.17]
132712977  spermidine synthase-like [KO:K00797] [EC:2.5.1.16]
132731361  spermidine synthase-like [KO:K00797] [EC:2.5.1.16]
132760025  LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
132745300  LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
rphi00220  Arginine biosynthesis
rphi00250  Alanine, aspartate and glutamate metabolism
rphi00270  Cysteine and methionine metabolism
rphi00430  Taurine and hypotaurine metabolism
KO pathway
ko00480   
LinkDB

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