KEGG   PATHWAY: rro03083
Entry
rro03083                    Pathway                                
Name
Polycomb repressive complex - Rhinopithecus roxellana (golden snub-nosed monkey)
Class
Genetic Information Processing; Chromosome
Pathway map
rro03083  Polycomb repressive complex
rro03083

Organism
Rhinopithecus roxellana (golden snub-nosed monkey) [GN:rro]
Gene
104680126  EZH1; histone-lysine N-methyltransferase EZH1 isoform X1 [KO:K17451] [EC:2.1.1.356]
104667012  EZH2; histone-lysine N-methyltransferase EZH2 isoform X1 [KO:K11430] [EC:2.1.1.356]
104656412  EED; polycomb protein EED isoform X2 [KO:K11462]
104669869  SUZ12; polycomb protein SUZ12 isoform X1 [KO:K11463]
104654858  RBBP4; histone-binding protein RBBP4 [KO:K10752]
104667071  RBBP7; histone-binding protein RBBP7 isoform X1 [KO:K11659]
104657965  PHF1; PHD finger protein 1 isoform X1 [KO:K11467]
104679509  MTF2; metal-response element-binding transcription factor 2 isoform X3 [KO:K11485]
104669130  PHF19; PHD finger protein 19 isoform X2 [KO:K11486]
104674876  EPOP; elongin BC and Polycomb repressive complex 2-associated protein [KO:K26259]
104682823  LCOR; ligand-dependent corepressor isoform X5 [KO:K26260]
104668331  AEBP2; zinc finger protein AEBP2 isoform X1 [KO:K17452]
104672583  JARID2; protein Jumonji isoform X1 [KO:K11478]
104663707  BAP1; ubiquitin carboxyl-terminal hydrolase BAP1 isoform X1 [KO:K08588] [EC:3.4.19.12]
104677885  ASXL2; putative Polycomb group protein ASXL2 isoform X1 [KO:K11471]
104675864  ASXL3; putative Polycomb group protein ASXL3 [KO:K11471]
104653706  ASXL1; putative Polycomb group protein ASXL1 isoform X2 [KO:K11471]
104664903  OGT; UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1 [KO:K09667] [EC:2.4.1.255]
104661167  HCFC1; host cell factor 1 isoform X3 [KO:K14966]
104654514  YY1; transcriptional repressor protein YY1 [KO:K09201]
104658120  MBD5; methyl-CpG-binding domain protein 5 isoform X1 [KO:K23219]
104682358  MBD6; methyl-CpG-binding domain protein 6 isoform X1 [KO:K26585]
104668116  FOXK1; forkhead box protein K1 [KO:K09404]
104655021  FOXK2; LOW QUALITY PROTEIN: forkhead box protein K2 [KO:K09404]
104666819  RNF2; E3 ubiquitin-protein ligase RING2 [KO:K10695] [EC:2.3.2.27]
104658081  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RING2-like [KO:K10695] [EC:2.3.2.27]
104657979  RING1; E3 ubiquitin-protein ligase RING1 [KO:K10695] [EC:2.3.2.27]
104674875  PCGF2; polycomb group RING finger protein 2 isoform X1 [KO:K11460]
104665676  BMI1; polycomb complex protein BMI-1 [KO:K11459]
104670522  CBX2; LOW QUALITY PROTEIN: chromobox protein homolog 2 [KO:K11451]
104670513  CBX4; E3 SUMO-protein ligase CBX4 isoform X1 [KO:K11452] [EC:2.3.2.-]
104682579  CBX6; chromobox protein homolog 6 isoform X1 [KO:K11453]
104682549  CBX7; chromobox protein homolog 7 isoform X1 [KO:K11454]
104670493  CBX8; chromobox protein homolog 8 isoform X1 [KO:K11455]
104672840  PHC1; polyhomeotic-like protein 1 isoform X1 [KO:K11456]
104677305  PHC2; polyhomeotic-like protein 2 isoform X7 [KO:K11457]
104671999  PHC3; polyhomeotic-like protein 3 isoform X1 [KO:K11458]
104679871  SCML1; sex comb on midleg-like protein 1 isoform X1 [KO:K11464]
104661308  SCML2; sex comb on midleg-like protein 2 isoform X1 [KO:K11465]
104654907  SCMH1; polycomb protein SCMH1 isoform X1 [KO:K11461]
104682659  SFMBT2; scm-like with four MBT domains protein 2 isoform X1 [KO:K26269]
104663686  SFMBT1; scm-like with four MBT domains protein 1 [KO:K26269]
104661685  AURKB; aurora kinase B isoform X2 [KO:K11479] [EC:2.7.11.1]
104662319  UBE2D3; ubiquitin-conjugating enzyme E2 D3 [KO:K06689] [EC:2.3.2.23]
104665619  UBE2D1; ubiquitin-conjugating enzyme E2 D1 [KO:K06689] [EC:2.3.2.23]
104671133  UBE2D4; ubiquitin-conjugating enzyme E2 D4 isoform X1 [KO:K06689] [EC:2.3.2.23]
104677399  ubiquitin-conjugating enzyme E2 D2-like [KO:K06689] [EC:2.3.2.23]
104681746  UBE2D2; ubiquitin-conjugating enzyme E2 D2 isoform X1 [KO:K06689] [EC:2.3.2.23]
104663651  USP16; ubiquitin carboxyl-terminal hydrolase 16 isoform X1 [KO:K11844] [EC:3.4.19.12]
104665778  USP45; ubiquitin carboxyl-terminal hydrolase 45 isoform X1 [KO:K11844] [EC:3.4.19.12]
104680162  RYBP; RING1 and YY1-binding protein [KO:K11469]
104672380  YAF2; YY1-associated factor 2 isoform X1 [KO:K11468]
104674821  PCGF1; polycomb group RING finger protein 1 [KO:K11487]
104664750  KDM2A; lysine-specific demethylase 2A isoform X1 [KO:K10276] [EC:1.14.11.27]
104666275  KDM2B; lysine-specific demethylase 2B isoform X1 [KO:K10276] [EC:1.14.11.27]
104662191  BCOR; BCL-6 corepressor isoform X1 [KO:K23215]
104674201  BCL-6 corepressor-like [KO:K23215]
115895681  LOW QUALITY PROTEIN: BCL-6 corepressor-like [KO:K23215]
104655376  BCORL1; BCL-6 corepressor-like protein 1 isoform X1 [KO:K26199]
104659810  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
104677263  S-phase kinase-associated protein 1-like [KO:K03094]
104678381  USP7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
104671719  PCGF3; polycomb group RING finger protein 3 [KO:K11488]
104662503  PCGF5; polycomb group RING finger protein 5 isoform X1 [KO:K11489]
104661923  CSNK2B; casein kinase II subunit beta isoform X1 [KO:K03115]
104672938  AUTS2; autism susceptibility gene 2 protein isoform X1 [KO:K23214]
104661594  FBRS; LOW QUALITY PROTEIN: probable fibrosin-1 [KO:K26253]
104674326  FBRSL1; fibrosin-1-like protein isoform X1 [KO:K26254]
104675471  DCAF7; DDB1- and CUL4-associated factor 7 [KO:K11805]
104670809  TEX10; testis-expressed protein 10 [KO:K14827]
104673260  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
104672289  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
104656537  PCGF6; polycomb group RING finger protein 6 [KO:K11470]
104675189  E2F6; transcription factor E2F6 isoform X1 [KO:K09390]
104671369  transcription factor Dp-1 isoform X1 [KO:K04683]
115894564  transcription factor Dp-1-like [KO:K04683]
115895835  transcription factor Dp-1-like [KO:K04683]
115892000  transcription factor Dp-1-like [KO:K04683]
104678435  MAX; protein max isoform X1 [KO:K04453]
104666906  MGA; MAX gene-associated protein isoform X2 [KO:K23399]
115892743  lethal(3)malignant brain tumor-like protein 2 [KO:K24387]
104678889  L3MBTL1; lethal(3)malignant brain tumor-like protein 1 isoform X1 [KO:K24387]
104655291  L3MBTL3; lethal(3)malignant brain tumor-like protein 3 isoform X2 [KO:K24387]
104672853  L3MBTL2; lethal(3)malignant brain tumor-like protein 2 isoform X1 [KO:K24387]
104670216  L3MBTL4; lethal(3)malignant brain tumor-like protein 4 isoform X1 [KO:K24387]
104656827  CBX3; chromobox protein homolog 3 isoform X1 [KO:K11586]
115897719  chromobox protein homolog 3-like [KO:K11586]
104669711  WDR5; WD repeat-containing protein 5 isoform X1 [KO:K14963]
104667922  WDR5B; WD repeat-containing protein 5B [KO:K14963]
104654770  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
104677352  histone deacetylase 1-like [KO:K06067] [EC:3.5.1.98]
104657112  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
Reference
  Authors
Richly H, Aloia L, Di Croce L
  Title
Roles of the Polycomb group proteins in stem cells and cancer.
  Journal
Cell Death Dis 2:e204 (2011)
DOI:10.1038/cddis.2011.84
Reference
  Authors
Chittock EC, Latwiel S, Miller TC, Muller CW
  Title
Molecular architecture of polycomb repressive complexes.
  Journal
Biochem Soc Trans 45:193-205 (2017)
DOI:10.1042/BST20160173
Reference
  Authors
Geng Z, Gao Z
  Title
Mammalian PRC1 Complexes: Compositional Complexity and Diverse Molecular Mechanisms.
  Journal
Int J Mol Sci 21:ijms21228594 (2020)
DOI:10.3390/ijms21228594
Reference
  Authors
Kim JJ, Kingston RE
  Title
Context-specific Polycomb mechanisms in development.
  Journal
Nat Rev Genet 23:680-695 (2022)
DOI:10.1038/s41576-022-00499-0
Reference
  Authors
Dong GJ, Xu JL, Qi YR, Yuan ZQ, Zhao W
  Title
Critical Roles of Polycomb Repressive Complexes in Transcription and Cancer.
  Journal
Int J Mol Sci 23:ijms23179574 (2022)
DOI:10.3390/ijms23179574
Reference
  Authors
Ryan CW, Peirent ER, Regan SL, Guxholli A, Bielas SL
  Title
H2A monoubiquitination: insights from human genetics and animal models.
  Journal
Hum Genet 10.1007/s00439-023-02557-x (2023)
DOI:10.1007/s00439-023-02557-x
KO pathway
ko03083   
LinkDB

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