KEGG   PATHWAY: salp00480
Entry
salp00480                   Pathway                                
Name
Glutathione metabolism - Salvelinus sp. IW2-2015 (Arctic char)
Class
Metabolism; Metabolism of other amino acids
Pathway map
salp00480  Glutathione metabolism
salp00480

Module
salp_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:salp00480]
Other DBs
GO: 0006749
Organism
Salvelinus sp. IW2-2015 (Arctic char) [GN:salp]
Gene
111976700  ggt7; glutathione hydrolase 7 [KO:K00681] [EC:2.3.2.2 3.4.19.13]
111971930  glutathione hydrolase 7-like [KO:K00681] [EC:2.3.2.2 3.4.19.13]
111971432  uncharacterized protein LOC111971432 [KO:K00681] [EC:2.3.2.2 3.4.19.13]
111981561  glutathione hydrolase 5 proenzyme-like isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
111973818  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
111961483  glutathione hydrolase 1 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
111961484  glutathione hydrolase 5 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
111975079  glutathione hydrolase 5 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
111964720  gamma-glutamylcyclotransferase-like [KO:K00682] [EC:4.3.2.9]
112068927  gamma-glutamylcyclotransferase-like [KO:K00682] [EC:4.3.2.9]
111964926  ggct; gamma-glutamylcyclotransferase [KO:K00682] [EC:4.3.2.9]
111956202  gamma-glutamylcyclotransferase [KO:K00682] [EC:4.3.2.9]
111953559  glutathione-specific gamma-glutamylcyclotransferase 1 [KO:K07232] [EC:4.3.2.7]
111963024  chac1; glutathione-specific gamma-glutamylcyclotransferase 1 [KO:K07232] [EC:4.3.2.7]
112075959  glutathione-specific gamma-glutamylcyclotransferase 1-like [KO:K07232] [EC:4.3.2.7]
112076305  chac2; glutathione-specific gamma-glutamylcyclotransferase 2 [KO:K07232] [EC:4.3.2.7]
111969021  glutathione-specific gamma-glutamylcyclotransferase 1-like [KO:K07232] [EC:4.3.2.7]
111972804  oplah; 5-oxoprolinase [KO:K01469] [EC:3.5.2.9]
111978043  glutamate--cysteine ligase catalytic subunit isoform X1 [KO:K11204] [EC:6.3.2.2]
111968105  glutamate--cysteine ligase catalytic subunit [KO:K11204] [EC:6.3.2.2]
111972193  glutamate--cysteine ligase regulatory subunit isoform X1 [KO:K11205]
111975829  glutamate--cysteine ligase regulatory subunit [KO:K11205]
111966463  gss; glutathione synthetase [KO:K21456] [EC:6.3.2.3]
111974503  putative aminopeptidase W07G4.4 [KO:K01255] [EC:3.4.11.1]
111957516  putative aminopeptidase W07G4.4 [KO:K01255] [EC:3.4.11.1]
111974354  putative aminopeptidase W07G4.4 [KO:K01255] [EC:3.4.11.1]
111952186  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
111962384  aminopeptidase N [KO:K11140] [EC:3.4.11.2]
111962256  anpep; aminopeptidase N isoform X1 [KO:K11140] [EC:3.4.11.2]
112071358  glutathione S-transferase Mu 3-like [KO:K00799] [EC:2.5.1.18]
111963770  gstt2b; glutathione S-transferase theta-2B [KO:K00799] [EC:2.5.1.18]
111977807  glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
111958036  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
111974560  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
111979654  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
111968802  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
111956690  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
111965550  mgst2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
111955053  glutathione S-transferase A [KO:K00799] [EC:2.5.1.18]
112072913  LOW QUALITY PROTEIN: glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
111968110  glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
112078759  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
112078760  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
111978328  gsto1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
111965855  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
111967603  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
111967604  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
111964845  gstk1; glutathione S-transferase kappa 1 [KO:K13299] [EC:2.5.1.18]
111973822  hpgds; hematopoietic prostaglandin D synthase isoform X1 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
111960781  lancl1; LOW QUALITY PROTEIN: lanC-like protein 1 [KO:K25210] [EC:2.5.1.18]
111977091  N-acetyltransferase 8 [KO:K20838] [EC:2.3.1.80 2.3.1.-]
112074940  probable N-acetyltransferase CML1 [KO:K20838] [EC:2.3.1.80 2.3.1.-]
111970525  N-acetyltransferase 8 [KO:K20838] [EC:2.3.1.80 2.3.1.-]
111965909  gsr; glutathione reductase, mitochondrial isoform X1 [KO:K00383] [EC:1.8.1.7]
111953090  LOW QUALITY PROTEIN: isocitrate dehydrogenase [NADP], mitochondrial-like [KO:K00031] [EC:1.1.1.42]
111962433  LOW QUALITY PROTEIN: isocitrate dehydrogenase [NADP], mitochondrial-like [KO:K00031] [EC:1.1.1.42]
112070136  isocitrate dehydrogenase [NADP] cytoplasmic-like isoform X1 [KO:K00031] [EC:1.1.1.42]
111976757  isocitrate dehydrogenase [NADP] cytoplasmic [KO:K00031] [EC:1.1.1.42]
111966486  pgd; 6-phosphogluconate dehydrogenase, decarboxylating [KO:K00033] [EC:1.1.1.44 1.1.1.343]
111966245  glucose-6-phosphate 1-dehydrogenase isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
111976507  glucose-6-phosphate 1-dehydrogenase isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
111966825  LOW QUALITY PROTEIN: glucose-6-phosphate 1-dehydrogenase-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
112070295  txndc12; thioredoxin domain-containing protein 12 [KO:K05360] [EC:1.8.4.2]
111952959  phospholipid hydroperoxide glutathione peroxidase, mitochondrial-like isoform X1 [KO:K05361] [EC:1.11.1.12]
111957159  phospholipid hydroperoxide glutathione peroxidase, mitochondrial-like [KO:K05361] [EC:1.11.1.12]
111975698  phospholipid hydroperoxide glutathione peroxidase, mitochondrial-like isoform X1 [KO:K05361] [EC:1.11.1.12]
112070983  probable glutathione peroxidase 8 [KO:K00432] [EC:1.11.1.9]
111976084  gpx7; glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
111966020  glutathione peroxidase 3-like [KO:K00432] [EC:1.11.1.9]
111970316  glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
111967176  glutathione peroxidase 3-like [KO:K00432] [EC:1.11.1.9]
111963264  glutathione peroxidase 6 [KO:K00432] [EC:1.11.1.9]
112071104  gpx8; probable glutathione peroxidase 8 [KO:K00432] [EC:1.11.1.9]
111968757  gpx2; glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
111956686  peroxiredoxin-6 isoform X1 [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
111972265  peroxiredoxin-6 [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
111968602  ornithine decarboxylase 1 [KO:K01581] [EC:4.1.1.17]
111963390  ornithine decarboxylase 1 [KO:K01581] [EC:4.1.1.17]
111966479  srm; spermidine synthase [KO:K00797] [EC:2.5.1.16]
111950654  spermine synthase [KO:K00802] [EC:2.5.1.22]
111964261  spermine synthase isoform X1 [KO:K00802] [EC:2.5.1.22]
111980701  ribonucleoside-diphosphate reductase large subunit isoform X1 [KO:K10807] [EC:1.17.4.1]
111950589  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
111954357  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
111972586  rrm2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
salp00220  Arginine biosynthesis
salp00250  Alanine, aspartate and glutamate metabolism
salp00270  Cysteine and methionine metabolism
salp00430  Taurine and hypotaurine metabolism
KO pathway
ko00480   
LinkDB

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