KEGG   PATHWAY: sanh03420
Entry
sanh03420                   Pathway                                
Name
Nucleotide excision repair - Sinocyclocheilus anshuiensis
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
Pathway map
sanh03420  Nucleotide excision repair
sanh03420

Other DBs
GO: 0006289
Organism
Sinocyclocheilus anshuiensis [GN:sanh]
Gene
107695112  RING-box protein 1-like [KO:K03868] [EC:2.3.2.32]
107672143  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
107664345  cullin-4B-like isoform X1 [KO:K10609]
107654650  cul4a; cullin-4A [KO:K10609]
107658014  cullin-4B [KO:K10609]
107681355  LOW QUALITY PROTEIN: DNA damage-binding protein 1-like [KO:K10610]
107681436  LOW QUALITY PROTEIN: DNA damage-binding protein 1-like [KO:K10610]
107686311  ddb2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
107669671  xpc; DNA repair protein complementing XP-C cells isoform X1 [KO:K10838]
107702626  UV excision repair protein RAD23 homolog B-like [KO:K10839]
107660841  UV excision repair protein RAD23 homolog B-like [KO:K10839]
107704496  UV excision repair protein RAD23 homolog B-like [KO:K10839]
107675389  UV excision repair protein RAD23 homolog A-like [KO:K10839]
107694545  UV excision repair protein RAD23 homolog B-like isoform X1 [KO:K10839]
107694827  UV excision repair protein RAD23 homolog A-like [KO:K10839]
107663123  caltractin-like [KO:K10840]
107657849  DNA excision repair protein ERCC-8-like [KO:K10570]
107700552  ercc8; DNA excision repair protein ERCC-8 isoform X1 [KO:K10570]
107673869  DNA excision repair protein ERCC-6-like [KO:K10841]
107668807  DNA excision repair protein ERCC-6-like isoform X1 [KO:K10841]
107679112  uvssa; UV-stimulated scaffold protein A [KO:K23720]
107665858  LOW QUALITY PROTEIN: DNA-directed RNA polymerase II subunit RPB1-like [KO:K03006] [EC:2.7.7.6]
107657282  polr2a; DNA-directed RNA polymerase II subunit RPB1 [KO:K03006] [EC:2.7.7.6]
107677351  DNA-directed RNA polymerase II subunit RPB2-like [KO:K03010] [EC:2.7.7.6]
107697614  DNA-directed RNA polymerase II subunit RPB2 [KO:K03010] [EC:2.7.7.6]
107674973  DNA-directed RNA polymerase II subunit RPB3-like [KO:K03011]
107667812  DNA-directed RNA polymerase II subunit RPB3 [KO:K03011]
107671554  DNA-directed RNA polymerase II subunit RPB4-like [KO:K03012]
107671669  DNA-directed RNA polymerase II subunit RPB4 [KO:K03012]
107655243  DNA-directed RNA polymerases I, II, and III subunit RPABC1 [KO:K03013]
107669821  DNA-directed RNA polymerases I, II, and III subunit RPABC1-like [KO:K03013]
107660381  DNA-directed RNA polymerases I, II, and III subunit RPABC1-like [KO:K03013]
107679479  polr2f; DNA-directed RNA polymerases I, II, and III subunit RPABC2 [KO:K03014]
107674489  DNA-directed RNA polymerases I, II, and III subunit RPABC2-like [KO:K03014]
107664727  DNA-directed RNA polymerase II subunit RPB7 [KO:K03015]
107662033  DNA-directed RNA polymerase II subunit RPB7-like [KO:K03015]
107668490  DNA-directed RNA polymerases I, II, and III subunit RPABC3 [KO:K03016]
107668663  DNA-directed RNA polymerases I, II, and III subunit RPABC3-like isoform X1 [KO:K03016]
107679009  DNA-directed RNA polymerase II subunit RPB9 [KO:K03017]
107684604  DNA-directed RNA polymerase II subunit RPB9 [KO:K03017]
107662297  DNA-directed RNA polymerases I, II, and III subunit RPABC5 [KO:K03007]
107685232  DNA-directed RNA polymerases I, II, and III subunit RPABC5 [KO:K03007]
107672846  polr2k; DNA-directed RNA polymerases I, II, and III subunit RPABC4 [KO:K03009]
107698637  DNA-directed RNA polymerases I, II, and III subunit RPABC4-like [KO:K03009]
107681903  DNA-directed RNA polymerase II subunit RPB11-a-like [KO:K03008]
107685871  DNA-directed RNA polymerase II subunit RPB11-a [KO:K03008]
107700427  DNA-directed RNA polymerase II subunit GRINL1A-like [KO:K21987]
107670778  DNA-directed RNA polymerase II subunit GRINL1A-like [KO:K21987]
107699696  cyclin-dependent kinase 7-like [KO:K02202] [EC:2.7.11.22 2.7.11.23]
107703229  cyclin-dependent kinase 7 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
107675563  LOW QUALITY PROTEIN: CDK-activating kinase assembly factor MAT1-like [KO:K10842]
107668823  CDK-activating kinase assembly factor MAT1-like [KO:K10842]
107660965  cyclin-H-like isoform X1 [KO:K06634]
107669504  ccnh; cyclin-H isoform X1 [KO:K06634]
107677608  TFIIH basal transcription factor complex helicase XPB subunit-like [KO:K10843] [EC:5.6.2.4]
107660024  TFIIH basal transcription factor complex helicase XPB subunit [KO:K10843] [EC:5.6.2.4]
107690444  TFIIH basal transcription factor complex helicase XPD subunit-like [KO:K10844] [EC:5.6.2.3]
107683824  TFIIH basal transcription factor complex helicase XPD subunit-like [KO:K10844] [EC:5.6.2.3]
107665362  general transcription factor IIH subunit 5 [KO:K10845]
107659223  general transcription factor IIH subunit 5-like [KO:K10845]
107701051  gtf2h1; general transcription factor IIH subunit 1 [KO:K03141]
107687272  general transcription factor IIH subunit 1-like [KO:K03141]
107672775  general transcription factor IIH subunit 2-like [KO:K03142]
107675954  gtf2h3; general transcription factor IIH subunit 3 isoform X1 [KO:K03143]
107677462  general transcription factor IIH subunit 4-like [KO:K03144]
107694324  general transcription factor IIH subunit 4-like [KO:K03144]
107665925  DNA repair protein complementing XP-A cells homolog [KO:K10847]
107664922  rpa1; replication protein A 70 kDa DNA-binding subunit [KO:K07466]
107685155  replication protein A 70 kDa DNA-binding subunit-like [KO:K07466]
107689153  rpa2; replication protein A 32 kDa subunit [KO:K10739]
107689013  replication protein A 32 kDa subunit-like [KO:K10739]
107672835  replication protein A 14 kDa subunit-like [KO:K10740]
107702426  replication protein A 14 kDa subunit-like [KO:K10740]
107702436  replication protein A 14 kDa subunit-like [KO:K10740]
107692079  DNA repair endonuclease XPF-like [KO:K10848] [EC:3.1.-.-]
107669240  DNA repair endonuclease XPF-like [KO:K10848] [EC:3.1.-.-]
107659901  ercc1; DNA excision repair protein ERCC-1 [KO:K10849]
107653418  DNA polymerase delta catalytic subunit-like [KO:K02327] [EC:2.7.7.7]
107690328  DNA polymerase delta catalytic subunit-like [KO:K02327] [EC:2.7.7.7]
107702813  pold2; DNA polymerase delta subunit 2 [KO:K02328]
107681526  DNA polymerase delta subunit 3-like [KO:K03504]
107681185  pold3; LOW QUALITY PROTEIN: DNA polymerase delta subunit 3 [KO:K03504]
107674245  DNA polymerase delta subunit 4-like [KO:K03505]
107664544  DNA polymerase delta subunit 4-like [KO:K03505]
107704563  LOW QUALITY PROTEIN: DNA polymerase epsilon catalytic subunit A-like [KO:K02324] [EC:2.7.7.7]
107668756  DNA polymerase epsilon catalytic subunit A-like [KO:K02324] [EC:2.7.7.7]
107660564  pole2; DNA polymerase epsilon subunit 2 [KO:K02325] [EC:2.7.7.7]
107691032  DNA polymerase epsilon subunit 3-like [KO:K02326] [EC:2.7.7.7]
107693859  DNA polymerase epsilon subunit 3-like [KO:K02326] [EC:2.7.7.7]
107680508  DNA polymerase epsilon subunit 4-like [KO:K03506] [EC:2.7.7.7]
107685140  DNA polymerase epsilon subunit 4-like [KO:K03506] [EC:2.7.7.7]
107658578  proliferating cell nuclear antigen [KO:K04802]
107688976  proliferating cell nuclear antigen-like [KO:K04802]
107700290  replication factor C subunit 1-like [KO:K10754]
107671924  rfc1; replication factor C subunit 1 isoform X1 [KO:K10754]
107693531  replication factor C subunit 2-like isoform X1 [KO:K10755]
107669364  replication factor C subunit 2-like [KO:K10755]
107693018  rfc4; replication factor C subunit 4 [KO:K10755]
107704514  replication factor C subunit 5-like isoform X1 [KO:K10756]
107686217  rfc3; replication factor C subunit 3 [KO:K10756]
107691679  replication factor C subunit 3-like isoform X1 [KO:K10756]
107668751  replication factor C subunit 5 [KO:K10756]
107659894  DNA ligase 1-like isoform X1 [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
107692877  DNA ligase 1-like isoform X1 [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
Reference
PMID:11436314
  Authors
Sugasawa K.
  Title
[Molecular mechanism of mammalian nucleotide excision repair]
  Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
PMID:11436316
  Authors
Nakatsu Y.
  Title
[Transcription-coupled repair and Cockayne syndrome]
  Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
PMID:11436323
  Authors
Nakagawa N, Masui R, Kuramitsu S.
  Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
  Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
PMID:17276014
  Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
  Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
  Journal
Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020
Reference
PMID:17884153
  Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
  Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
  Journal
Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043
Reference
PMID:16922398
  Authors
Sugasawa K.
  Title
[DNA repair pathways involving Cul4A ubiquitin ligases]
  Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
PMID:18018633
  Authors
Ito S, Ando D, Tanaka K.
  Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
  Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related
pathway
sanh03020  RNA polymerase
sanh04120  Ubiquitin mediated proteolysis
KO pathway
ko03420   
LinkDB

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