KEGG   PATHWAY: saqi00270
Entry
saqi00270                   Pathway                                
Name
Cysteine and methionine metabolism - Silvanigrella aquatica
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
saqi00270  Cysteine and methionine metabolism
saqi00270

Other DBs
GO: 0006534 0006555
Organism
Silvanigrella aquatica [GN:saqi]
Gene
AXG55_11805  cystathionine beta-lyase [KO:K01738] [EC:2.5.1.47]
AXG55_13415  cystathionine gamma-synthase [KO:K01758] [EC:4.4.1.1]
AXG55_01115  hypothetical protein [KO:K14155] [EC:4.4.1.13]
AXG55_05300  methionine synthase [KO:K00548] [EC:2.1.1.13]
AXG55_05310  bifunctional homocysteine S-methyltransferase/methylenetetrahydrofolate reductase [KO:K24042] [EC:2.1.1.13 1.5.1.54]
AXG55_13025  5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase [KO:K00549] [EC:2.1.1.14]
AXG55_00760  methionine adenosyltransferase [KO:K00789] [EC:2.5.1.6]
AXG55_09330  S-adenosylmethionine decarboxylase [KO:K01611] [EC:4.1.1.50]
AXG55_02285  spermidine synthase [KO:K00797] [EC:2.5.1.16]
AXG55_05045  hypothetical protein [KO:K00797] [EC:2.5.1.16]
AXG55_05175  hypothetical protein [KO:K00797] [EC:2.5.1.16]
AXG55_03445  methylthioadenosine phosphorylase [KO:K00772] [EC:2.4.2.28]
AXG55_01275  hypothetical protein [KO:K12960] [EC:3.5.4.31 3.5.4.28]
AXG55_03440  S-methyl-5-thioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
AXG55_03430  methylthioribulose-1-phosphate dehydratase [KO:K08964] [EC:4.2.1.109]
AXG55_03435  hypothetical protein [KO:K08965] [EC:5.3.2.5]
AXG55_06055  hypothetical protein [KO:K08968] [EC:1.8.4.14]
AXG55_13635  DNA (cytosine-5-)-methyltransferase [KO:K00558] [EC:2.1.1.37]
AXG55_13590  adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]
AXG55_03355  hypothetical protein [KO:K01505] [EC:3.5.99.7]
AXG55_12160  aspartate kinase [KO:K00928] [EC:2.7.2.4]
AXG55_12405  aspartate kinase [KO:K00928] [EC:2.7.2.4]
AXG55_07200  bifunctional aspartate kinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
AXG55_09465  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
AXG55_02795  hypothetical protein [KO:K00826] [EC:2.6.1.42]
AXG55_05640  hypothetical protein [KO:K00826] [EC:2.6.1.42]
AXG55_07970  hypothetical protein [KO:K01919] [EC:6.3.2.2]
AXG55_12955  hypothetical protein [KO:K01920] [EC:6.3.2.3]
AXG55_11010  hypothetical protein [KO:K00812] [EC:2.6.1.1]
AXG55_09690  hypothetical protein [KO:K11358] [EC:2.6.1.1]
AXG55_05235  malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
AXG55_05930  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
AXG55_12810  hypothetical protein [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
saqi00010  Glycolysis / Gluconeogenesis
saqi00250  Alanine, aspartate and glutamate metabolism
saqi00260  Glycine, serine and threonine metabolism
saqi00290  Valine, leucine and isoleucine biosynthesis
saqi00430  Taurine and hypotaurine metabolism
saqi00480  Glutathione metabolism
saqi00620  Pyruvate metabolism
saqi00640  Propanoate metabolism
saqi00770  Pantothenate and CoA biosynthesis
saqi00900  Terpenoid backbone biosynthesis
saqi00920  Sulfur metabolism
KO pathway
ko00270   
LinkDB

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