KEGG   PATHWAY: sbq04612
Entry
sbq04612                    Pathway                                
Name
Antigen processing and presentation - Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
Class
Organismal Systems; Immune system
Pathway map
sbq04612  Antigen processing and presentation
sbq04612

Other DBs
GO: 0019885 0019886 0042591
Organism
Saimiri boliviensis boliviensis (Bolivian squirrel monkey) [GN:sbq]
Gene
101033464  IFNG; interferon gamma [KO:K04687]
101031357  TNF; tumor necrosis factor isoform X2 [KO:K03156]
101053918  PSME1; proteasome activator complex subunit 1 isoform X2 [KO:K06696]
101050066  PSME2; proteasome activator complex subunit 2 [KO:K06697]
101035032  PSME3; proteasome activator complex subunit 3 isoform X1 [KO:K06698]
101049152  HSPA1A; heat shock 70 kDa protein 1A/1B [KO:K03283]
101049467  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
101032912  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
101050736  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
101052310  HSPA2; heat shock-related 70 kDa protein 2 [KO:K26598]
101033095  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
101033641  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
101035124  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
101039180  heat shock protein HSP 90-beta [KO:K04079]
101051018  heat shock protein 90 homolog [KO:K04079]
101028609  LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like [KO:K04079]
101042893  LOW QUALITY PROTEIN: saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101043856  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
101046108  HLA class I histocompatibility antigen, B-27 alpha chain-like [KO:K06751]
104650390  class I histocompatibility antigen, B alpha chain-like [KO:K06751]
104650398  putative HLA class I histocompatibility antigen, alpha chain H [KO:K06751]
101032412  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
101040674  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
101041111  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
101033054  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
101040568  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
101040877  class I histocompatibility antigen, Gogo-C*0202 alpha chain-like isoform X1 [KO:K06751]
101044935  LOW QUALITY PROTEIN: popy class I histocompatibility antigen, alpha chain E [KO:K06751]
101050220  LOW QUALITY PROTEIN: saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101050865  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
101050180  HSPA5; 78 kDa glucose-regulated protein [KO:K09490] [EC:3.6.4.10]
101030099  CANX; calnexin [KO:K08054]
101047890  B2M; beta-2-microglobulin isoform X2 [KO:K08055]
101042173  PDIA3; LOW QUALITY PROTEIN: protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
101043082  CALR; calreticulin [KO:K08057]
101044016  TAPBP; tapasin [KO:K08058]
101050206  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
101052015  TAP2; LOW QUALITY PROTEIN: antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
101045342  CD8A; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
101044254  CD8B; T-cell surface glycoprotein CD8 beta chain isoform X3 [KO:K06459]
101031681  uncharacterized protein LOC101031681 [KO:K10785]
101053728  killer cell immunoglobulin-like receptor 3DL3 isoform X1 [KO:K07980]
101036624  killer cell immunoglobulin-like receptor 3DL2 isoform X1 [KO:K07980]
101035987  killer cell immunoglobulin-like receptor 3DL2 [KO:K07980]
101046418  killer cell immunoglobulin-like receptor 3DL1 [KO:K07980]
104650262  LOW QUALITY PROTEIN: putative killer cell immunoglobulin-like receptor-like protein KIR3DX1 [KO:K07980]
101046441  KLRC1; NKG2-A/NKG2-B type II integral membrane protein isoform X1 [KO:K06541]
101047280  NKG2-C type II integral membrane protein isoform X2 [KO:K24233]
101045904  KLRD1; natural killer cells antigen CD94 [KO:K06516]
101036510  IFI30; gamma-interferon-inducible lysosomal thiol reductase [KO:K08059]
101041065  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
101047879  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
101053828  HLA class II histocompatibility antigen, DQ beta 1 chain-like isoform X2 [KO:K06752]
101054155  HLA class II histocompatibility antigen, DQ alpha 1 chain-like [KO:K06752]
101053201  HLA class II histocompatibility antigen, DQ beta 1 chain isoform X4 [KO:K06752]
101054478  HLA class II histocompatibility antigen, DQ alpha 2 chain isoform X1 [KO:K06752]
101052879  HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752]
101034517  HLA class II histocompatibility antigen, DRB1-4 beta chain-like isoform X1 [KO:K06752]
101041326  HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752]
101034208  HLA class II histocompatibility antigen, DRB1-9 beta chain-like [KO:K06752]
101041640  mamu class II histocompatibility antigen, DR alpha chain [KO:K06752]
101038711  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
104650606  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
101039757  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
101039220  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
101040088  HLA class II histocompatibility antigen, DP alpha 1 chain isoform X1 [KO:K06752]
101052651  HLA class II histocompatibility antigen, DQ beta 2 chain-like [KO:K06752]
101052977  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
101042292  CD74; HLA class II histocompatibility antigen gamma chain isoform X2 [KO:K06505]
101030077  CTSL; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
101051131  LOW QUALITY PROTEIN: putative cathepsin L-like protein 6 [KO:K01365] [EC:3.4.22.15]
101044698  CTSS; cathepsin S isoform X1 [KO:K01368] [EC:3.4.22.27]
101028824  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
101049282  CIITA; MHC class II transactivator isoform X1 [KO:K08060] [EC:2.7.11.1]
101038197  RFX5; DNA-binding protein RFX5 isoform X2 [KO:K08061]
101044361  RFXANK; DNA-binding protein RFXANK isoform X1 [KO:K08062]
101027776  RFXAP; regulatory factor X-associated protein [KO:K08063]
101034085  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
101031634  NFYA; nuclear transcription factor Y subunit alpha isoform X1 [KO:K08064]
101040468  NFYB; nuclear transcription factor Y subunit beta [KO:K08065]
101032445  NFYC; nuclear transcription factor Y subunit gamma isoform X2 [KO:K08066]
Reference
PMID:15771591
  Authors
Trombetta ES, Mellman I.
  Title
Cell biology of antigen processing in vitro and in vivo.
  Journal
Annu Rev Immunol 23:975-1028 (2005)
DOI:10.1146/annurev.immunol.22.012703.104538
Reference
PMID:15814328
  Authors
Inaba K, Inaba M.
  Title
Antigen recognition and presentation by dendritic cells.
  Journal
Int J Hematol 81:181-7 (2005)
DOI:10.1532/IJH97.04200
Reference
PMID:11905820
  Authors
Heath WR, Carbone FR.
  Title
Cross-presentation in viral immunity and self-tolerance.
  Journal
Nat Rev Immunol 1:126-34 (2001)
DOI:10.1038/35100512
Reference
PMID:15304636
  Authors
Abele R, Tampe R.
  Title
The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing.
  Journal
Physiology (Bethesda) 19:216-24 (2004)
DOI:10.1152/physiol.00002.2004
Reference
PMID:16200082
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
PMID:12776207
  Authors
Honey K, Rudensky AY.
  Title
Lysosomal cysteine proteases regulate antigen presentation.
  Journal
Nat Rev Immunol 3:472-82 (2003)
DOI:10.1038/nri1110
Reference
PMID:12974477
  Authors
Sercarz EE, Maverakis E.
  Title
Mhc-guided processing: binding of large antigen fragments.
  Journal
Nat Rev Immunol 3:621-9 (2003)
DOI:10.1038/nri1149
Reference
PMID:15224093
  Authors
Ackerman AL, Cresswell P.
  Title
Cellular mechanisms governing cross-presentation of exogenous antigens.
  Journal
Nat Immunol 5:678-84 (2004)
DOI:10.1038/ni1082
Reference
PMID:16181333
  Authors
Cresswell P, Ackerman AL, Giodini A, Peaper DR, Wearsch PA.
  Title
Mechanisms of MHC class I-restricted antigen processing and cross-presentation.
  Journal
Immunol Rev 207:145-57 (2005)
DOI:10.1111/j.0105-2896.2005.00316.x
Reference
PMID:15653312
  Authors
Zika E, Ting JP.
  Title
Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes.
  Journal
Curr Opin Immunol 17:58-64 (2005)
DOI:10.1016/j.coi.2004.11.008
Reference
PMID:11244040
  Authors
Reith W, Mach B.
  Title
The bare lymphocyte syndrome and the regulation of MHC expression.
  Journal
Annu Rev Immunol 19:331-73 (2001)
DOI:10.1146/annurev.immunol.19.1.331
Reference
PMID:15745856
  Authors
Lizee G, Basha G, Jefferies WA.
  Title
Tails of wonder: endocytic-sorting motifs key for exogenous antigen presentation.
  Journal
Trends Immunol 26:141-9 (2005)
DOI:10.1016/j.it.2005.01.005
Reference
PMID:15224094
  Authors
Watts C.
  Title
The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules.
  Journal
Nat Immunol 5:685-92 (2004)
DOI:10.1038/ni1088
Reference
PMID:15653315
  Authors
Kaufmann SH, Schaible UE.
  Title
Antigen presentation and recognition in bacterial infections.
  Journal
Curr Opin Immunol 17:79-87 (2005)
DOI:10.1016/j.coi.2004.12.004
Reference
PMID:20010787
  Authors
Groettrup M, Kirk CJ, Basler M
  Title
Proteasomes in immune cells: more than peptide producers?
  Journal
Nat Rev Immunol 10:73-8 (2010)
DOI:10.1038/nri2687
Related
pathway
sbq03050  Proteasome
sbq04650  Natural killer cell mediated cytotoxicity
sbq04660  T cell receptor signaling pathway
KO pathway
ko04612   
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