KEGG   PATHWAY: sce03440
Entry
sce03440                    Pathway                                
Name
Homologous recombination - Saccharomyces cerevisiae (budding yeast)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
sce03440  Homologous recombination
sce03440

Other DBs
GO: 0000724
Organism
Saccharomyces cerevisiae (budding yeast) [GN:sce]
Gene
YNL250W  RAD50; MRX complex DNA-binding subunit [KO:K10866] [EC:3.6.-.-]
YMR224C  MRE11; MRX complex nuclease subunit [KO:K10865]
YDR369C  XRS2; Xrs2p [KO:K10868]
YBL088C  TEL1; DNA-binding protein kinase TEL1 [KO:K04728] [EC:2.7.11.1]
YDR363W-A  SEM1; proteasome regulatory particle lid subunit SEM1 [KO:K10881]
YDR076W  RAD55; putative DNA-dependent ATPase RAD55 [KO:K10957]
YDR004W  RAD57; putative DNA-dependent ATPase RAD57 [KO:K10958]
YAR007C  RFA1; replication factor A subunit protein RFA1 [KO:K07466]
YNL312W  RFA2; Rfa2p [KO:K10739]
YER095W  RAD51; recombinase RAD51 [KO:K04482]
YML032C  RAD52; recombinase RAD52 [KO:K10873]
YDL059C  RAD59; Rad59p [KO:K10959]
YGL163C  RAD54; DNA-dependent ATPase RAD54 [KO:K10875] [EC:5.6.2.-]
YBR073W  RDH54; DNA-dependent ATPase RDH54 [KO:K10877] [EC:5.6.2.-]
YDL102W  POL3; DNA-directed DNA polymerase delta POL3 [KO:K02327] [EC:2.7.7.7]
YJR006W  POL31; DNA-directed DNA polymerase delta subunit POL31 [KO:K02328]
YJR043C  POL32; DNA polymerase delta subunit POL32 [KO:K03504]
YMR190C  SGS1; ATP-dependent DNA helicase SGS1 [KO:K10901] [EC:5.6.2.4]
YLR234W  TOP3; DNA topoisomerase 3 [KO:K03165] [EC:5.6.2.1]
YDR386W  MUS81; Mus81p [KO:K08991] [EC:3.1.22.-]
YBR098W  MMS4; Mms4p [KO:K10882] [EC:3.1.22.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   
LinkDB

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