KEGG   PATHWAY: sfh00260
Entry
sfh00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Sinorhizobium fredii HH103
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
sfh00260  Glycine, serine and threonine metabolism
sfh00260

Module
sfh_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:sfh00260]
sfh_M00555  Betaine biosynthesis, choline => betaine [PATH:sfh00260]
sfh_M00621  Glycine cleavage system [PATH:sfh00260]
sfh_M00919  Ectoine degradation, ectoine => aspartate [PATH:sfh00260]
sfh_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:sfh00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Sinorhizobium fredii HH103 [GN:sfh]
Gene
SFHH103_02584  lysC; aspartokinase, alpha and beta subunits [KO:K00928] [EC:2.7.2.4]
SFHH103_03469  putative aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
SFHH103_01301  thrA; thrA [KO:K00003] [EC:1.1.1.3]
SFHH103_06563  hom; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
SFHH103_00590  thrB; homoserine kinase [KO:K02204] [EC:2.7.1.39]
SFHH103_06566  thrB; homoserine kinase [KO:K02204] [EC:2.7.1.39]
SFHH103_00598  thrC; thrC [KO:K01733] [EC:4.2.3.1]
SFHH103_02880  putative low-specificity l-threonine aldolase [KO:K01620] [EC:4.1.2.48]
SFHH103_00889  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SFHH103_02473  sgaA; serine-glyoxylate aminotransferase-related [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
SFHH103_06180  putative D-isomer specific 2-hydroxyacid dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
SFHH103_03651  putative 2-hydroxyacid dehydrogenase protein [KO:K12972] [EC:1.1.1.79 1.1.1.81]
SFHH103_05192  putative glycerate kinase [KO:K11529] [EC:2.7.1.165]
SFHH103_03446  Hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
SFHH103_03661  gpm; Phosphoglycerate mutase 1 family protein [KO:K01834] [EC:5.4.2.11]
SFHH103_02740  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
SFHH103_05471  putative phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
SFHH103_03417  putative D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
SFHH103_02741  serC; serC [KO:K00831] [EC:2.6.1.52]
SFHH103_02128  kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
SFHH103_02127  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
SFHH103_03095  hemA; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
SFHH103_05259  hemA; 5-aminolevulinic acid synthase HemA [KO:K00643] [EC:2.3.1.37]
SFHH103_01441  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
SFHH103_01443  gcvt3; glycine cleavage system protein T2 [KO:K00605] [EC:2.1.2.10]
SFHH103_01173  lpda1; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SFHH103_03001  lpdA2; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SFHH103_03154  lpda3; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SFHH103_01442  gcvH; Glycine cleavage system H protein [KO:K02437]
SFHH103_00804  pssA; pssA [KO:K17103] [EC:2.7.8.8]
SFHH103_00638  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
SFHH103_00639  betB; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
SFHH103_03026  putative betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
SFHH103_00550  Rieske 2Fe-2S family protein [KO:K00479] [EC:1.14.13.251]
SFHH103_02484  Rieske 2Fe-2S family protein [KO:K00479] [EC:1.14.13.251]
SFHH103_02483  ferredoxin oxidoreductase protein [KO:K21832] [EC:1.14.13.251]
SFHH103_00551  oxidoreductase [KO:K21832] [EC:1.14.13.251]
SFHH103_02078  FAD dependent oxidoreductase [KO:K00315] [EC:1.5.8.4]
SFHH103_02910  soxA1; sarcosine oxidase, alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]
SFHH103_02912  soxB1; sarcosine oxidase, beta subunit [KO:K00303] [EC:1.5.3.24 1.5.3.1]
SFHH103_02909  soxG1; sarcosine oxidase, gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
SFHH103_02911  soxD1; sarcosine oxidase, delta subunit [KO:K00304] [EC:1.5.3.24 1.5.3.1]
SFHH103_01129  sdaA; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
SFHH103_01380  ilvA2; ilvA2 [KO:K01754] [EC:4.3.1.19]
SFHH103_02498  ilvA; ilvA [KO:K01754] [EC:4.3.1.19]
SFHH103_049155  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
SFHH103_02874  putative threonine dehydratase [KO:K01754] [EC:4.3.1.19]
SFHH103_06578  tdcB; putative threonine dehydratase [KO:K01754] [EC:4.3.1.19]
SFHH103_06609  putative threonine dehydratase [KO:K01754] [EC:4.3.1.19]
SFHH103_03609  putative L-serine ammonia-lyase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
SFHH103_03528  trpA; trpA [KO:K01695] [EC:4.2.1.20]
SFHH103_03527  trpB; Tryptophan synthase, beta chain [KO:K01696] [EC:4.2.1.20]
SFHH103_03484  ectC; Ectoine synthase [KO:K06720] [EC:4.2.1.108]
SFHH103_04917  putative dipeptidase [KO:K15783] [EC:3.5.4.44]
SFHH103_04918  putative succinylglutamate desuccinylase/aspartoacylase family protein [KO:K15784] [EC:3.5.1.125]
SFHH103_04905  conserved hypothetical protein [KO:K15785] [EC:2.6.1.76]
SFHH103_06584  bioA; hypothetical protein [KO:K15785] [EC:2.6.1.76]
SFHH103_04907  putative succinate-semialdehyde dehydrogenase [NAD(P)+] [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
sfh00010  Glycolysis / Gluconeogenesis
sfh00020  Citrate cycle (TCA cycle)
sfh00230  Purine metabolism
sfh00250  Alanine, aspartate and glutamate metabolism
sfh00270  Cysteine and methionine metabolism
sfh00290  Valine, leucine and isoleucine biosynthesis
sfh00300  Lysine biosynthesis
sfh00330  Arginine and proline metabolism
sfh00460  Cyanoamino acid metabolism
sfh00470  D-Amino acid metabolism
sfh00564  Glycerophospholipid metabolism
sfh00600  Sphingolipid metabolism
sfh00620  Pyruvate metabolism
sfh00630  Glyoxylate and dicarboxylate metabolism
sfh00640  Propanoate metabolism
sfh00680  Methane metabolism
sfh00860  Porphyrin metabolism
sfh00920  Sulfur metabolism
KO pathway
ko00260   
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