KEGG PATHWAY: sgre00260

PATHWAY: sgre00260

Entry

sgre00260                   Pathway

Name

Glycine, serine and threonine metabolism - Schistocerca gregaria (desert locust)

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

sgre00260

Glycine, serine and threonine metabolism

Module

sgre_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:sgre00260]

sgre_M00338

Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:sgre00260]

sgre_M00621

Glycine cleavage system [PATH:sgre00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Schistocerca gregaria (desert locust) [GN:sgre]

Gene

126334613

uncharacterized protein LOC126334613 isoform X1 [KO:K01620] [EC:4.1.2.48]

126295024

serine hydroxymethyltransferase, mitochondrial-like [KO:K00600] [EC:2.1.2.1]

126297764

serine hydroxymethyltransferase, mitochondrial-like [KO:K00600] [EC:2.1.2.1]

126316752

serine hydroxymethyltransferase 2-like [KO:K00600] [EC:2.1.2.1]

126325353

serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]

126327203

uncharacterized protein LOC126327203 [KO:K00600] [EC:2.1.2.1]

126353750

alanine--glyoxylate aminotransferase-like [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]

126355828

alanine--glyoxylate aminotransferase-like [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]

126355964

alanine--glyoxylate aminotransferase-like [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]

126335274

glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]

126278316

glycerate kinase [KO:K11529] [EC:2.7.1.165]

126315365

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase-like [KO:K01834] [EC:5.4.2.11]

126267012

phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]

126295405

D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

126316771

D-3-phosphoglycerate dehydrogenase-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]

126293368

phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

126349907

phosphoserine phosphatase isoform X1 [KO:K01079] [EC:3.1.3.3]

126365930

2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]

126266872

2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial-like isoform X1 [KO:K00639] [EC:2.3.1.29]

126297581

5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]

126335010

amine oxidase [flavin-containing]-like [KO:K00274] [EC:1.4.3.4]

126298909

glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]

126293404

aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]

126279031

dihydrolipoyl dehydrogenase, mitochondrial-like [KO:K00382] [EC:1.8.1.4]

126297520

dihydrolipoyl dehydrogenase, mitochondrial-like isoform X1 [KO:K00382] [EC:1.8.1.4]

126316432

dihydrolipoyl dehydrogenase, mitochondrial-like [KO:K00382] [EC:1.8.1.4]

126267350

glycine cleavage system H protein, mitochondrial [KO:K02437]

126281672

D-aspartate oxidase isoform X1 [KO:K00273] [EC:1.4.3.3]

126354727

alanine--glyoxylate aminotransferase 2, mitochondrial-like isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]

126354731

alanine--glyoxylate aminotransferase 2, mitochondrial-like isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]

126350022

alpha-aminoadipic semialdehyde dehydrogenase-like [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]

126266840

alpha-aminoadipic semialdehyde dehydrogenase-like [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]

126354127

betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]

126299609

sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]

126291779

glycine N-methyltransferase isoform X1 [KO:K00552] [EC:2.1.1.20]

126330208

cystathionine beta-synthase-like isoform X1 [KO:K01697] [EC:4.2.1.22]

126313300

cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]

126299553

cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]

126328062

cystathionine gamma-lyase-like [KO:K01758] [EC:4.4.1.1]

126298221

L-threonine ammonia-lyase isoform X1 [KO:K01754] [EC:4.3.1.19]

126266599

L-serine dehydratase/L-threonine deaminase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]

126282115

D-threo-3-hydroxyaspartate dehydratase-like isoform X1 [KO:K20498] [EC:4.3.1.18]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721