KEGG   PATHWAY: slx00230
Entry
slx00230                    Pathway                                
Name
Purine metabolism - Streptomyces lavendulae subsp. lavendulae
Class
Metabolism; Nucleotide metabolism
Pathway map
slx00230  Purine metabolism
slx00230

Module
slx_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:slx00230]
slx_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:slx00230]
slx_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:slx00230]
slx_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:slx00230]
slx_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:slx00230]
slx_M00546  Purine degradation, xanthine => urea [PATH:slx00230]
slx_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:slx00230]
slx_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:slx00230]
Other DBs
GO: 0006163 0042278
Organism
Streptomyces lavendulae subsp. lavendulae [GN:slx]
Gene
SLAV_40120  prs2; Ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
SLAV_22430  prs1; Ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
SLAV_18295  purF; Amidophosphoribosyltransferase precursor [KO:K00764] [EC:2.4.2.14]
SLAV_18380  purD; Phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
SLAV_15375  purN; Phosphoribosylglycinamide formyltransferase [KO:K11175] [EC:2.1.2.2]
SLAV_18320  purL; Phosphoribosylformylglycinamidine synthase 2 [KO:K23269] [EC:6.3.5.3]
SLAV_18330  phosphoribosylformylglycinamidine synthase subunit PurS [KO:K23264] [EC:6.3.5.3]
SLAV_18325  purQ; Phosphoribosylformylglycinamidine synthase 1 [KO:K23265] [EC:6.3.5.3 3.5.1.2]
SLAV_18290  purM; Phosphoribosylformylglycinamidine cyclo-ligase [KO:K01933] [EC:6.3.3.1]
SLAV_22750  purK; N5-carboxyaminoimidazole ribonucleotide synthase [KO:K01589] [EC:6.3.4.18]
SLAV_22755  purE; N5-carboxyaminoimidazole ribonucleotide mutase [KO:K01588] [EC:5.4.99.18]
SLAV_18365  purC; Phosphoribosylaminoimidazole-succinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
SLAV_31210  purB; Adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
SLAV_15370  purH; Bifunctional purine biosynthesis protein PurH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
SLAV_29930  apt; Adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
SLAV_05045  yhcR1; Endonuclease YhcR precursor [KO:K01081] [EC:3.1.3.5]
SLAV_17915  yhcR2; Endonuclease YhcR precursor [KO:K01081] [EC:3.1.3.5]
SLAV_03165  surE; 5'-nucleotidase SurE [KO:K03787] [EC:3.1.3.5 3.1.3.6]
SLAV_23685  nagD; Ribonucleotide monophosphatase NagD [KO:K02566] [EC:3.1.3.5]
SLAV_14955  punA; Purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
SLAV_26830  yfiH; Laccase domain protein YfiH [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
SLAV_35165  rihA; Pyrimidine-specific ribonucleoside hydrolase RihA [KO:K25589] [EC:3.2.2.2 3.2.2.3]
SLAV_21000  hpt; Hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
SLAV_27360  guaB4; Inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
SLAV_15580  putative oxidoreductase [KO:K00088] [EC:1.1.1.205]
SLAV_15585  guaB3; Inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
SLAV_24525  ndkA; Nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
SLAV_23490  rdgB; dITP/XTP pyrophosphatase [KO:K01519] [EC:3.6.1.66]
SLAV_05140  ndhF1; Nicotinate dehydrogenase FAD-subunit [KO:K13481] [EC:1.17.1.4]
SLAV_05145  xdhA1; Xanthine dehydrogenase molybdenum-binding subunit [KO:K13482] [EC:1.17.1.4]
SLAV_15515  guaA; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
SLAV_30360  guaB5; Inosine-5'-monophosphate dehydrogenase [KO:K26110] [EC:1.7.1.7]
SLAV_21930  guaD2; Guanine deaminase [KO:K01487] [EC:3.5.4.3]
SLAV_30130  gmk; Guanylate kinase [KO:K00942] [EC:2.7.4.8]
SLAV_10880  nrdJ; Vitamin B12-dependent ribonucleotide reductase [KO:K00525] [EC:1.17.4.1]
SLAV_13475  nrdZ; Ribonucleoside-diphosphate reductase NrdZ [KO:K00525] [EC:1.17.4.1]
SLAV_13480  nrdB; Ribonucleoside-diphosphate reductase subunit beta [KO:K00526] [EC:1.17.4.1]
SLAV_25045  dgt; Deoxyguanosinetriphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
SLAV_29935  relA2; Bifunctional (p)ppGpp synthase/hydrolase relA [KO:K01139] [EC:2.7.6.5 3.1.7.2]
SLAV_10935  relA1; Bifunctional (p)ppGpp synthase/hydrolase relA [KO:K01139] [EC:2.7.6.5 3.1.7.2]
SLAV_21360  ppx; Exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
SLAV_22595  gppA; Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
SLAV_14900  pH-sensitive adenylate cyclase [KO:K01768] [EC:4.6.1.1]
SLAV_20385  purA; Adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
SLAV_09145  adoK1; Adenosine kinase [KO:K00856] [EC:2.7.1.20]
SLAV_40460  adoK3; Adenosine kinase [KO:K00856] [EC:2.7.1.20]
SLAV_26435  adoK2; Adenosine kinase [KO:K00856] [EC:2.7.1.20]
SLAV_15035  Adenine deaminase [KO:K01488] [EC:3.5.4.4]
SLAV_16060  Aminodeoxyfutalosine deaminase [KO:K01488] [EC:3.5.4.4]
SLAV_27515  cpdB; 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor [KO:K01119] [EC:3.1.4.16 3.1.3.6]
SLAV_09040  adk1; Adenylate kinase [KO:K00939] [EC:2.7.4.3]
SLAV_15830  adk2; Adenylate kinase [KO:K00939] [EC:2.7.4.3]
SLAV_06015  cpdA; 3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA [KO:K03651] [EC:3.1.4.53]
SLAV_29845  AP-4-A phosphorylase [KO:K19710] [EC:2.7.7.53]
SLAV_09565  sat_cysC1; putative bifunctional SAT/APS kinase [KO:K00860] [EC:2.7.1.25]
SLAV_39775  sat_cysC2; putative bifunctional SAT/APS kinase [KO:K00860] [EC:2.7.1.25]
SLAV_09575  cysNC1; Bifunctional enzyme CysN/CysC [KO:K00956] [EC:2.7.7.4]
SLAV_39765  cysNC2; Bifunctional enzyme CysN/CysC [KO:K00956] [EC:2.7.7.4]
SLAV_09570  cysD1; Sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
SLAV_39770  cysD2; Sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
SLAV_08750  uox1; Uricase [KO:K00365] [EC:1.7.3.3]
SLAV_19850  uox2; Uricase [KO:K00365] [EC:1.7.3.3]
SLAV_08755  hiuH; 5-hydroxyisourate hydrolase precursor [KO:K07127] [EC:3.5.2.17]
SLAV_08760  pucL; Uric acid degradation bifunctional protein PucL [KO:K16840] [EC:4.1.1.97]
SLAV_15185  OHCU decarboxylase [KO:K16840] [EC:4.1.1.97]
SLAV_08655  allB; Allantoinase [KO:K01466] [EC:3.5.2.5]
SLAV_08650  alc; allantoicase [KO:K01477] [EC:3.5.3.4]
SLAV_12080  ureC1; Urease subunit alpha [KO:K01428] [EC:3.5.1.5]
SLAV_31295  ureC2; Urease subunit alpha [KO:K01428] [EC:3.5.1.5]
SLAV_31290  ureB; Urease subunit beta [KO:K01429] [EC:3.5.1.5]
SLAV_31285  ureA2; Urease subunit gamma [KO:K01430] [EC:3.5.1.5]
SLAV_12085  ureA1; Urease subunit alpha [KO:K14048] [EC:3.5.1.5]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
slx00030  Pentose phosphate pathway
slx00220  Arginine biosynthesis
slx00250  Alanine, aspartate and glutamate metabolism
slx00260  Glycine, serine and threonine metabolism
slx00340  Histidine metabolism
slx00630  Glyoxylate and dicarboxylate metabolism
slx00730  Thiamine metabolism
slx00740  Riboflavin metabolism
slx00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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