KEGG   PATHWAY: sma00630
Entry
sma00630                    Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Streptomyces avermitilis
Class
Metabolism; Carbohydrate metabolism
Pathway map
sma00630  Glyoxylate and dicarboxylate metabolism
sma00630

Module
sma_M00012  Glyoxylate cycle [PATH:sma00630]
sma_M00621  Glycine cleavage system [PATH:sma00630]
sma_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:sma00630]
Other DBs
GO: 0046487 0043648
Organism
Streptomyces avermitilis [GN:sma]
Gene
SAVERM_2043  aceA; putative isocitrate lyase [KO:K01637] [EC:4.1.3.1]
SAVERM_4599  acsA1; putative acetyl-CoA synthetase [KO:K01895] [EC:6.2.1.1]
SAVERM_2031  acsA4; putative acetyl-CoA synthetase [KO:K01895] [EC:6.2.1.1]
SAVERM_2044  aceB2; putative malate synthase [KO:K01638] [EC:2.3.3.9]
SAVERM_2000  aceB1; putative malate synthase [KO:K01638] [EC:2.3.3.9]
SAVERM_3436  mdh; putative malate/lactate dehydrogenase [KO:K00024] [EC:1.1.1.37]
SAVERM_2427  citA3; putative citrate synthase [KO:K01647] [EC:2.3.3.1]
SAVERM_5330  citA1; putative citrate synthase [KO:K01647] [EC:2.3.3.1]
SAVERM_3859  citA2; putative citrate synthase [KO:K01647] [EC:2.3.3.1]
SAVERM_2428  putative citrate synthase-like protein [KO:K01647] [EC:2.3.3.1]
SAVERM_2258  acnA; putative aconitase [KO:K01681] [EC:4.2.1.3]
SAVERM_1384  fadA5; putative 3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
SAVERM_2856  fadA1; putative 3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
SAVERM_1681  fadA4; putative 3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
SAVERM_1242  putative nonspecific lipid-transfer protein [KO:K00626] [EC:2.3.1.9]
SAVERM_5842  fadA7; putative 3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
SAVERM_3512  fadA2; putative 3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
SAVERM_6199  fadA3; putative 3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
SAVERM_414  pteB; putative dehydrogenase [KO:K14446] [EC:1.3.1.85]
SAVERM_2857  hypothetical protein [KO:K05606] [EC:5.1.99.1]
SAVERM_1912  meaA1; putative methylmalonyl-CoA mutase, coenzyme B12-dependent alpha subunit [KO:K14447] [EC:5.4.99.63]
SAVERM_3337  accA3; putative acyl-CoA carboxylase, alpha subunit [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.3.4.14]
SAVERM_3331  accD4; putative acyl-CoA carboxylase, beta subunit [KO:K27094] [EC:6.4.1.3 6.4.1.- 2.1.3.15]
SAVERM_3332  putative secreted protein [KO:K27095]
SAVERM_2040  meaA2; putative methylmalonyl-CoA mutase, coenzyme B12-dependent alpha subunit [KO:K01847] [EC:5.4.99.2]
SAVERM_2039  mcmB; putative methylmalonyl-CoA mutase, beta subunit [KO:K01847] [EC:5.4.99.2]
SAVERM_3382  mcmA2; putative methylmalonyl-CoA mutase, alpha subunit [KO:K01848] [EC:5.4.99.2]
SAVERM_5151  glcD2; putative (S)-2-hydroxy-acid oxidase [KO:K00104] [EC:1.1.99.14]
SAVERM_1386  glcD1; putative (S)-2-hydroxy-acid oxidase [KO:K00104] [EC:1.1.99.14]
SAVERM_348  katB; putative catalase [KO:K03781] [EC:1.11.1.6]
SAVERM_2026  katA3; putative catalase [KO:K03781] [EC:1.11.1.6]
SAVERM_3052  katA1; putative catalase [KO:K03781] [EC:1.11.1.6]
SAVERM_3224  katA2; putative catalase [KO:K03781] [EC:1.11.1.6]
SAVERM_3908  putative hydrolase [KO:K01091] [EC:3.1.3.18]
SAVERM_6725  glnA4; putative glutamine synthetase [KO:K01915] [EC:6.3.1.2]
SAVERM_5954  glnA1; putative glutamine synthetase [KO:K01915] [EC:6.3.1.2]
SAVERM_5997  glnA2; putative glutamine synthetase [KO:K01915] [EC:6.3.1.2]
SAVERM_6005  glnA3; putative glutamine synthetase [KO:K01915] [EC:6.3.1.2]
SAVERM_2775  glyA1; putative serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SAVERM_3419  glyA3; putative serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SAVERM_2908  glyA2; putative serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SAVERM_6987  gcvP; putative glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
SAVERM_2773  gcvT; putative glycine cleavage system protein T (aminomethyltransferase) [KO:K00605] [EC:2.1.2.10]
SAVERM_6024  lpdA1; putative dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SAVERM_2154  lpdA2; putative dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SAVERM_2774  gcvH; putative glycine cleavage system protein H [KO:K02437]
SAVERM_2028  gcl; putative glyoxylate carboligase [KO:K01608] [EC:4.1.1.47]
SAVERM_2024  gip; putative hydroxypyruvate isomerase [KO:K01816] [EC:5.3.1.22]
SAVERM_2025  garR; putative 2-hydroxy-3-oxopropionate reductase [KO:K00042] [EC:1.1.1.60]
SAVERM_1918  glxK; putative glycerate kinase [KO:K00865] [EC:2.7.1.165]
SAVERM_5878  kdgA; putative 2-keto-3-deoxygluconate 6-phosphate aldolase and 2-keto-4-hydroxyglutarate aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
SAVERM_2972  sucA; putative 2-oxoglutarate dehydrogenase [KO:K01616] [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
SAVERM_1941  fdh; putative NAD-dependent formate dehydrogenase [KO:K00122] [EC:1.17.1.9]
SAVERM_3846  purU; putative formyltetrahydrofolate deformylase [KO:K01433] [EC:3.5.1.10]
SAVERM_1820  frc; putative formyl-coenzyme A transferase [KO:K07749] [EC:2.8.3.16]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
sma00010  Glycolysis / Gluconeogenesis
sma00020  Citrate cycle (TCA cycle)
sma00030  Pentose phosphate pathway
sma00053  Ascorbate and aldarate metabolism
sma00071  Fatty acid degradation
sma00230  Purine metabolism
sma00250  Alanine, aspartate and glutamate metabolism
sma00260  Glycine, serine and threonine metabolism
sma00620  Pyruvate metabolism
sma00710  Carbon fixation by Calvin cycle
sma00750  Vitamin B6 metabolism
sma00910  Nitrogen metabolism
KO pathway
ko00630   
LinkDB

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