KEGG PATHWAY: smuc00270

PATHWAY: smuc00270

Entry

smuc00270                   Pathway

Name

Cysteine and methionine metabolism - Skermanella mucosa

Description

Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].

Class

Metabolism; Amino acid metabolism

Pathway map

smuc00270

Cysteine and methionine metabolism

Module

smuc_M00017

Methionine biosynthesis, aspartate => homoserine => methionine [PATH:smuc00270]

smuc_M00021

Cysteine biosynthesis, serine => cysteine [PATH:smuc00270]

Other DBs

GO:	0006534 0006555

Organism

Skermanella mucosa [GN:smuc]

Gene

JL100_026430

cysE; serine O-acetyltransferase [KO:K00640] [EC:2.3.1.30]

JL100_017905

cysE; serine O-acetyltransferase [KO:K00640] [EC:2.3.1.30]

JL100_029810

cysK; cysteine synthase A [KO:K01738] [EC:2.5.1.47]

JL100_032530

cysteine synthase family protein [KO:K01738] [EC:2.5.1.47]

JL100_012025

cysteine synthase A [KO:K01738] [EC:2.5.1.47]

JL100_019245

metC; cystathionine beta-lyase [KO:K01760] [EC:4.4.1.13]

JL100_005340

metH; methionine synthase [KO:K00548] [EC:2.1.1.13]

JL100_028515

metK; methionine adenosyltransferase [KO:K00789] [EC:2.5.1.6]

JL100_015965

5'-methylthioadenosine/adenosylhomocysteine nucleosidase [KO:K01243] [EC:3.2.2.9]

JL100_026240

mtnK; S-methyl-5-thioribose kinase [KO:K00899] [EC:2.7.1.100]

JL100_004460

pgeF; peptidoglycan editing factor PgeF [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]

JL100_018510

amidohydrolase family protein [KO:K12960] [EC:3.5.4.31 3.5.4.28]

JL100_002840

mtnA; S-methyl-5-thioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]

JL100_012545

GAF domain-containing protein [KO:K08968] [EC:1.8.4.14]

JL100_005865

DNA cytosine methyltransferase [KO:K00558] [EC:2.1.1.37]

JL100_011335

ahcY; adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]

JL100_021875

aspartate kinase [KO:K00928] [EC:2.7.2.4]

JL100_025925

aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

JL100_004070

aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

JL100_010035

homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

JL100_030805

homoserine O-acetyltransferase [KO:K00641] [EC:2.3.1.31 2.3.1.46]

JL100_012575

alpha/beta fold hydrolase [KO:K00641] [EC:2.3.1.31 2.3.1.46]

JL100_016765

homoserine O-acetyltransferase [KO:K00641] [EC:2.3.1.31 2.3.1.46]

JL100_013640

PLP-dependent aspartate aminotransferase family protein [KO:K01739] [EC:2.5.1.48]

JL100_020435

O-acetylhomoserine aminocarboxypropyltransferase [KO:K01740] [EC:2.5.1.49]

JL100_024080

O-acetylhomoserine aminocarboxypropyltransferase [KO:K01740] [EC:2.5.1.49]

JL100_026440

PLP-dependent transferase [KO:K01740] [EC:2.5.1.49]

JL100_029715

metZ; O-succinylhomoserine sulfhydrylase [KO:K10764] [EC:2.5.1.-]

JL100_026600

aminotransferase class IV [KO:K00826] [EC:2.6.1.42]

JL100_036060

aminotransferase class IV [KO:K00826] [EC:2.6.1.42]

JL100_004550

branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]

JL100_017445

branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]

JL100_020330

glutamate--cysteine ligase [KO:K01919] [EC:6.3.2.2]

JL100_029060

gshB; glutathione synthase [KO:K01920] [EC:6.3.2.3]

JL100_020855

aspartate transaminase [KO:K00812] [EC:2.6.1.1]

JL100_012015

sseA; 3-mercaptopyruvate sulfurtransferase [KO:K01011] [EC:2.8.1.1 2.8.1.2]

JL100_003690

L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]

JL100_013875

3-phosphoglycerate dehydrogenase [KO:K16843] [EC:1.1.1.310]

JL100_025420

mdh; malate dehydrogenase [KO:K00024] [EC:1.1.1.37]

JL100_026650

L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]

JL100_005710

hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

JL100_007785

C-terminal binding protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]

JL100_010870

serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

JL100_014870

serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

JL100_010865

phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]

Compound

C00019

S-Adenosyl-L-methionine

C00021

S-Adenosyl-L-homocysteine

C00022

Pyruvate

C00041

L-Alanine

C00049

L-Aspartate

C00051

Glutathione

C00059

Sulfate

C00065

L-Serine

C00073

L-Methionine

C00094

Sulfite

C00097

L-Cysteine

C00109

2-Oxobutanoate

C00155

L-Homocysteine

C00170

5'-Methylthioadenosine

C00197

3-Phospho-D-glycerate

C00263

L-Homoserine

C00283

Hydrogen sulfide

C00409

Methanethiol

C00441

L-Aspartate 4-semialdehyde

C00491

L-Cystine

C00506

L-Cysteate

C00606

3-Sulfino-L-alanine

C00793

D-Cysteine

C00957

Mercaptopyruvate

C00979

O-Acetyl-L-serine

C01005

O-Phospho-L-serine

C01077

O-Acetyl-L-homoserine

C01118

O-Succinyl-L-homoserine

C01137

S-Adenosylmethioninamine

C01180

4-Methylthio-2-oxobutanoic acid

C01234

1-Aminocyclopropane-1-carboxylate

C01817

L-Homocystine

C01962

Thiocysteine

C02218

Dehydroalanine

C02291

L-Cystathionine

C02356

(S)-2-Aminobutanoate

C02989

L-Methionine S-oxide

C03082

4-Phospho-L-aspartate

C03089

5-Methylthio-D-ribose

C03145

N-Formylmethionine

C03232

3-Phosphonooxypyruvate

C03431

S-Inosyl-L-homocysteine

C03539

S-Ribosyl-L-homocysteine

C04188

S-Methyl-5-thio-D-ribose 1-phosphate

C04582

S-Methyl-5-thio-D-ribulose 1-phosphate

C05324

Nicotianamine

C05524

Aminoacyl-L-methionine

C05526

S-Glutathionyl-L-cysteine

C05527

3-Sulfinylpyruvate

C05528

3-Sulfopyruvate

C05823

3-Mercaptolactate

C05824

S-Sulfo-L-cysteine

C06547

Ethylene

C08276

3-(Methylthio)propanoate

C09306

Sulfur dioxide

C11437

1-Deoxy-D-xylulose 5-phosphate

C11481

HSO3-

C11499

(S)-3-Sulfolactate

C11537

(2R)-3-Sulfolactate

C15606

1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one

C15650

2,3-Diketo-5-methylthiopentyl-1-phosphate

C15651

2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate

C18049

N-Acyl-L-homoserine lactone

C19787

5'-S-Methyl-5'-thioinosine

C21015

gamma-L-Glutamyl-L-2-aminobutyrate

C21016

Ophthalmate

C22359

S-Methyl-1-thio-D-xylulose 5-phosphate

Reference

PMID:15102328

Authors

Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A

Title

Bacterial variations on the methionine salvage pathway.

Journal

BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9

Reference

PMID:14551435

Authors

Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.

Title

A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.

Journal

Science 302:286-90 (2003)
DOI:10.1126/science.1086997

Reference

PMID:12022921

Authors

Sekowska A, Danchin A.

Title

The methionine salvage pathway in Bacillus subtilis.

Journal

BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8

Reference

PMID:12670965

Authors

Berger BJ, English S, Chan G, Knodel MH.

Title

Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.

Journal

J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003

Reference

PMID:17169919

Authors

Goyer A, Collakova E, Shachar-Hill Y, Hanson AD

Title

Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.

Journal

Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055

Reference

PMID:17030798

Authors

Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S

Title

Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.

Journal

Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103

Reference

PMID:18625006

Authors

Pirkov I, Norbeck J, Gustafsson L, Albers E

Title

A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.

Journal

FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x

Reference

PMID:18391471

Authors

Ashida H, Saito Y, Kojima C, Yokota A

Title

Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.

Journal

Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651

Reference

PMID:10613873

Authors

Kitabatake M, So MW, Tumbula DL, Soll D

Title

Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?

Journal

J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000

Reference

PMID:12644499

Authors

Mino K, Ishikawa K

Title

Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.

Journal

J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003

Reference

PMID:18520135

Authors

Tanabe S

Title

Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.

Journal

Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:19270684

Authors