KEGG   PATHWAY: ssia00230
Entry
ssia00230                   Pathway                                
Name
Purine metabolism - Streptomyces alfalfae
Class
Metabolism; Nucleotide metabolism
Pathway map
ssia00230  Purine metabolism
ssia00230

Module
ssia_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:ssia00230]
ssia_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:ssia00230]
ssia_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:ssia00230]
ssia_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:ssia00230]
ssia_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:ssia00230]
ssia_M00546  Purine degradation, xanthine => urea [PATH:ssia00230]
ssia_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:ssia00230]
ssia_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:ssia00230]
Other DBs
GO: 0006163 0042278
Organism
Streptomyces alfalfae [GN:ssia]
Gene
A7J05_21100  ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
A7J05_18755  amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
A7J05_18660  phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
A7J05_14525  phosphoribosylglycinamide formyltransferase [KO:K11175] [EC:2.1.2.2]
A7J05_18730  phosphoribosylformylglycinamidine synthase II [KO:K23269] [EC:6.3.5.3]
A7J05_18720  phosphoribosylformylglycinamidine synthase subunit PurS [KO:K23264] [EC:6.3.5.3]
A7J05_18725  phosphoribosylformylglycinamidine synthase I [KO:K23265] [EC:6.3.5.3 3.5.1.2]
A7J05_18760  phosphoribosylformylglycinamidine cyclo-ligase [KO:K01933] [EC:6.3.3.1]
A7J05_21600  5-(carboxyamino)imidazole ribonucleotide synthase [KO:K01589] [EC:6.3.4.18]
A7J05_21605  5-(carboxyamino)imidazole ribonucleotide mutase [KO:K01588] [EC:5.4.99.18]
A7J05_18675  phosphoribosylaminoimidazolesuccinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
A7J05_32015  adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
A7J05_14520  bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
A7J05_29520  adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
A7J05_19130  bifunctional metallophosphatase/5'-nucleotidase [KO:K01081] [EC:3.1.3.5]
A7J05_22625  HAD family hydrolase [KO:K02566] [EC:3.1.3.5]
A7J05_14035  purine-nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
A7J05_26480  laccase [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
A7J05_02395  rihB; ribonucleoside hydrolase [KO:K25589] [EC:3.2.2.2 3.2.2.3]
A7J05_16315  hypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
A7J05_14725  inosine 5-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
A7J05_14730  IMP dehydrogenase [KO:K00088] [EC:1.1.1.205]
A7J05_24025  nucleoside-diphosphate kinase [KO:K00940] [EC:2.7.4.6]
A7J05_22415  non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family [KO:K01519] [EC:3.6.1.66]
A7J05_35000  xanthine dehydrogenase small subunit [KO:K13481] [EC:1.17.1.4]
A7J05_34995  xanthine dehydrogenase molybdopterin binding subunit [KO:K13482] [EC:1.17.1.4]
A7J05_31795  oxidoreductase [KO:K11177] [EC:1.17.1.4]
A7J05_02240  xanthine dehydrogenase [KO:K11177] [EC:1.17.1.4]
A7J05_31790  molybdopterin dehydrogenase [KO:K11178] [EC:1.17.1.4]
A7J05_02235  molybdopterin dehydrogenase [KO:K11178] [EC:1.17.1.4]
A7J05_31785  (2Fe-2S)-binding protein [KO:K13483]
A7J05_02230  oxidoreductase [KO:K13483]
A7J05_14650  glutamine-hydrolyzing GMP synthase [KO:K01951] [EC:6.3.5.2]
A7J05_29740  inosine 5-monophosphate dehydrogenase [KO:K26110] [EC:1.7.1.7]
A7J05_22515  hypothetical protein [KO:K01487] [EC:3.5.4.3]
A7J05_29685  guanylate kinase [KO:K00942] [EC:2.7.4.8]
A7J05_12550  ribonucleoside-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
A7J05_10050  ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [KO:K00525] [EC:1.17.4.1]
A7J05_12555  ribonucleoside-diphosphate reductase [KO:K00526] [EC:1.17.4.1]
A7J05_24690  deoxyguanosinetriphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
A7J05_29525  GTP pyrophosphokinase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
A7J05_10110  kinase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
A7J05_06100  hypothetical protein [KO:K01524] [EC:3.6.1.11 3.6.1.40]
A7J05_21255  exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
A7J05_16060  exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
A7J05_13980  adenylate cyclase [KO:K01768] [EC:4.6.1.1]
A7J05_17160  adenylosuccinate synthase [KO:K01939] [EC:6.3.4.4]
A7J05_26085  ribokinase [KO:K00856] [EC:2.7.1.20]
A7J05_15150  adenosine deaminase [KO:K01488] [EC:3.5.4.4]
A7J05_14110  adenosine deaminase [KO:K01488] [EC:3.5.4.4]
A7J05_24340  adenosine deaminase [KO:K21053] [EC:3.5.4.2]
A7J05_26850  bifunctional metallophosphatase/5'-nucleotidase [KO:K01119] [EC:3.1.4.16 3.1.3.6]
A7J05_14925  adenylate kinase [KO:K00939] [EC:2.7.4.3]
A7J05_25885  metallophosphoesterase [KO:K03651] [EC:3.1.4.53]
A7J05_29440  HIT family hydrolase [KO:K19710] [EC:2.7.7.53]
A7J05_08460  adenylyl-sulfate kinase [KO:K00860] [EC:2.7.1.25]
A7J05_08470  sulfate adenylyltransferase [KO:K00956] [EC:2.7.7.4]
A7J05_08465  sulfate adenylyltransferase small subunit [KO:K00957] [EC:2.7.7.4]
A7J05_07840  urate oxidase [KO:K00365] [EC:1.7.3.3]
A7J05_17010  dimethylaniline monooxygenase [KO:K22879] [EC:1.14.13.113]
A7J05_07845  hydroxyisourate hydrolase [KO:K07127] [EC:3.5.2.17]
A7J05_07850  2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K16840] [EC:4.1.1.97]
A7J05_14300  hypothetical protein [KO:K16840] [EC:4.1.1.97]
A7J05_07670  allantoinase [KO:K01466] [EC:3.5.2.5]
A7J05_07665  allantoicase [KO:K01477] [EC:3.5.3.4]
A7J05_34275  urease subunit alpha [KO:K01428] [EC:3.5.1.5]
A7J05_11185  urease subunit alpha [KO:K01428] [EC:3.5.1.5]
A7J05_32145  urease subunit alpha [KO:K01428] [EC:3.5.1.5]
A7J05_32140  urease subunit beta [KO:K01429] [EC:3.5.1.5]
A7J05_32135  urease subunit gamma [KO:K01430] [EC:3.5.1.5]
A7J05_34280  hypothetical protein [KO:K14048] [EC:3.5.1.5]
A7J05_11190  urease subunit gamma [KO:K14048] [EC:3.5.1.5]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
ssia00030  Pentose phosphate pathway
ssia00220  Arginine biosynthesis
ssia00250  Alanine, aspartate and glutamate metabolism
ssia00260  Glycine, serine and threonine metabolism
ssia00340  Histidine metabolism
ssia00630  Glyoxylate and dicarboxylate metabolism
ssia00730  Thiamine metabolism
ssia00740  Riboflavin metabolism
ssia00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

DBGET integrated database retrieval system