KEGG   PATHWAY: sspl00053
Entry
sspl00053                   Pathway                                
Name
Ascorbate and aldarate metabolism - Salvia splendens (scarlet sage)
Class
Metabolism; Carbohydrate metabolism
Pathway map
sspl00053  Ascorbate and aldarate metabolism
sspl00053

Module
sspl_M00114  Ascorbate biosynthesis, plants, fructose-6P => ascorbate [PATH:sspl00053]
Other DBs
GO: 0019852 0019577 0019572
Organism
Salvia splendens (scarlet sage) [GN:sspl]
Gene
121745188  UDP-glucose 6-dehydrogenase 1-like [KO:K00012] [EC:1.1.1.22]
121771699  UDP-glucose 6-dehydrogenase 1 [KO:K00012] [EC:1.1.1.22]
121787613  UDP-glucose 6-dehydrogenase 3-like [KO:K00012] [EC:1.1.1.22]
121762563  UDP-glucose 6-dehydrogenase 3-like [KO:K00012] [EC:1.1.1.22]
121765233  UDP-glucose 6-dehydrogenase 3-like [KO:K00012] [EC:1.1.1.22]
121741842  UDP-glucose 6-dehydrogenase 1-like [KO:K00012] [EC:1.1.1.22]
121754923  UDP-glucose 6-dehydrogenase 1-like [KO:K00012] [EC:1.1.1.22]
121768604  UDP-glucose 6-dehydrogenase 1-like [KO:K00012] [EC:1.1.1.22]
121785967  UDP-sugar pyrophosphorylase-like [KO:K12447] [EC:2.7.7.64]
121783004  UDP-sugar pyrophosphorylase-like [KO:K12447] [EC:2.7.7.64]
121810605  UDP-sugar pyrophosphorylase-like [KO:K12447] [EC:2.7.7.64]
121749043  glucuronokinase 1-like [KO:K16190] [EC:2.7.1.43]
121750932  glucuronokinase 1-like [KO:K16190] [EC:2.7.1.43]
121790148  inositol oxygenase 4-like [KO:K00469] [EC:1.13.99.1]
121748886  inositol oxygenase 4-like [KO:K00469] [EC:1.13.99.1]
121749437  inositol oxygenase 1-like isoform X1 [KO:K00469] [EC:1.13.99.1]
121792363  inositol oxygenase 1-like isoform X1 [KO:K00469] [EC:1.13.99.1]
121753178  inositol oxygenase 4-like [KO:K00469] [EC:1.13.99.1]
121766550  inositol oxygenase 1-like [KO:K00469] [EC:1.13.99.1]
121761172  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
121761186  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
121796850  aldose reductase-like [KO:K00002] [EC:1.1.1.2]
121764871  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
121792117  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
121778219  L-gulonolactone oxidase 3-like [KO:K00103] [EC:1.1.3.8]
121780982  L-gulonolactone oxidase 3-like [KO:K00103] [EC:1.1.3.8]
121767404  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
121782090  L-gulonolactone oxidase 3-like [KO:K00103] [EC:1.1.3.8]
121773719  GDP-mannose 3,5-epimerase 2 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
121777196  GDP-mannose 3,5-epimerase 2-like [KO:K10046] [EC:5.1.3.18 5.1.3.-]
121777197  GDP-mannose 3,5-epimerase 2-like [KO:K10046] [EC:5.1.3.18 5.1.3.-]
121806859  GDP-mannose 3,5-epimerase 2-like [KO:K10046] [EC:5.1.3.18 5.1.3.-]
121759063  GDP-L-galactose phosphorylase 2-like [KO:K14190] [EC:2.7.7.69]
121773226  GDP-L-galactose phosphorylase 1-like [KO:K14190] [EC:2.7.7.69]
121787388  GDP-L-galactose phosphorylase 1-like [KO:K14190] [EC:2.7.7.69]
121775762  GDP-L-galactose phosphorylase 1-like [KO:K14190] [EC:2.7.7.69]
121783267  GDP-L-galactose phosphorylase 2-like isoform X1 [KO:K14190] [EC:2.7.7.69]
121755827  GDP-L-galactose phosphorylase 2-like [KO:K14190] [EC:2.7.7.69]
121773348  inositol monophosphatase 3-like [KO:K10047] [EC:3.1.3.25 3.1.3.93]
121788306  inositol monophosphatase 3-like isoform X1 [KO:K10047] [EC:3.1.3.25 3.1.3.93]
121789369  inositol monophosphatase 3-like isoform X1 [KO:K10047] [EC:3.1.3.25 3.1.3.93]
121777073  inositol monophosphatase 3-like [KO:K10047] [EC:3.1.3.25 3.1.3.93]
121804509  inositol monophosphatase 3-like [KO:K10047] [EC:3.1.3.25 3.1.3.93]
121749700  bifunctional phosphatase IMPL2, chloroplastic-like [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
121753114  bifunctional phosphatase IMPL2, chloroplastic-like [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
121805512  L-galactose dehydrogenase-like [KO:K17744] [EC:1.1.1.316]
121809633  L-galactose dehydrogenase-like isoform X1 [KO:K17744] [EC:1.1.1.316]
121749499  L-galactono-1,4-lactone dehydrogenase, mitochondrial-like [KO:K00225] [EC:1.3.2.3]
121753111  L-galactono-1,4-lactone dehydrogenase, mitochondrial-like [KO:K00225] [EC:1.3.2.3]
121784605  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
121799395  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
121799841  UDP-glucuronate 4-epimerase 6-like [KO:K08679] [EC:5.1.3.6]
121748330  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
121762126  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
121749147  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
121762427  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
121791982  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
121763771  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
121792580  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
121751883  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
121779459  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
121752480  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
121753229  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
121781125  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
121795740  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
121796102  UDP-glucuronate 4-epimerase 6-like [KO:K08679] [EC:5.1.3.6]
121796393  UDP-glucuronate 4-epimerase 4-like [KO:K08679] [EC:5.1.3.6]
121809330  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
121798253  D-galacturonate reductase-like [KO:K19642] [EC:1.1.1.365]
121793704  D-galacturonate reductase-like [KO:K19642] [EC:1.1.1.365]
121807646  D-galacturonate reductase-like isoform X1 [KO:K19642] [EC:1.1.1.365]
121799065  monodehydroascorbate reductase-like [KO:K08232] [EC:1.6.5.4]
121771818  monodehydroascorbate reductase, chloroplastic/mitochondrial-like [KO:K08232] [EC:1.6.5.4]
121786129  monodehydroascorbate reductase-like [KO:K08232] [EC:1.6.5.4]
121748521  monodehydroascorbate reductase-like [KO:K08232] [EC:1.6.5.4]
121762614  monodehydroascorbate reductase [KO:K08232] [EC:1.6.5.4]
121780374  monodehydroascorbate reductase 4, peroxisomal-like [KO:K08232] [EC:1.6.5.4]
121782312  monodehydroascorbate reductase 4, peroxisomal-like [KO:K08232] [EC:1.6.5.4]
121795507  monodehydroascorbate reductase-like [KO:K08232] [EC:1.6.5.4]
121769430  monodehydroascorbate reductase, chloroplastic/mitochondrial-like isoform X1 [KO:K08232] [EC:1.6.5.4]
121785033  putative L-ascorbate peroxidase 6 [KO:K00434] [EC:1.11.1.11]
121745414  L-ascorbate peroxidase 1, cytosolic-like [KO:K00434] [EC:1.11.1.11]
121786877  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
121748480  L-ascorbate peroxidase 3-like isoform X1 [KO:K00434] [EC:1.11.1.11]
121750417  putative L-ascorbate peroxidase 6 [KO:K00434] [EC:1.11.1.11]
121764629  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
121779838  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial isoform X1 [KO:K00434] [EC:1.11.1.11]
121752419  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
121742289  L-ascorbate peroxidase 1, cytosolic-like [KO:K00434] [EC:1.11.1.11]
121795610  L-ascorbate peroxidase, cytosolic-like [KO:K00434] [EC:1.11.1.11]
121782989  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial isoform X1 [KO:K00434] [EC:1.11.1.11]
121786266  glutathione S-transferase DHAR3, chloroplastic-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
121760121  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
121763473  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
121765800  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
121783291  glutathione S-transferase DHAR3, chloroplastic-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
121757384  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
121746770  L-ascorbate oxidase-like [KO:K00423] [EC:1.10.3.3]
121786430  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
121787522  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
121789464  L-ascorbate oxidase-like [KO:K00423] [EC:1.10.3.3]
121749749  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
121763006  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
121778707  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
121751746  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
121765060  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
121781115  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
121783798  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
121769907  glutaredoxin-C3 [KO:K00128] [EC:1.2.1.3]
121811165  aldehyde dehydrogenase-like [KO:K00128] [EC:1.2.1.3]
121756856  aldehyde dehydrogenase family 3 member F1-like [KO:K00128] [EC:1.2.1.3]
121758725  aldehyde dehydrogenase-like [KO:K00128] [EC:1.2.1.3]
121786119  aldehyde dehydrogenase-like [KO:K00128] [EC:1.2.1.3]
121787403  benzaldehyde dehydrogenase, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
121801245  benzaldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
121774679  aldehyde dehydrogenase family 3 member F1-like [KO:K00128] [EC:1.2.1.3]
121801869  aldehyde dehydrogenase-like [KO:K00128] [EC:1.2.1.3]
121748310  benzaldehyde dehydrogenase, mitochondrial-like isoform X1 [KO:K00128] [EC:1.2.1.3]
121762588  aldehyde dehydrogenase family 2 member B4, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
121777234  aldehyde dehydrogenase family 3 member F1-like isoform X1 [KO:K00128] [EC:1.2.1.3]
121767169  glutaredoxin-C3-like [KO:K00128] [EC:1.2.1.3]
121781063  aldehyde dehydrogenase-like [KO:K00128] [EC:1.2.1.3]
121755808  aldehyde dehydrogenase-like [KO:K00128] [EC:1.2.1.3]
121772143  aldehyde dehydrogenase family 7 member B4-like [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
121801193  aldehyde dehydrogenase family 7 member B4-like isoform X1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
121789974  aldehyde dehydrogenase family 7 member B4-like [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
121797122  aldehyde dehydrogenase family 7 member B4-like isoform X1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
121769176  aldehyde dehydrogenase family 7 member B4-like [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00216  D-Arabinose
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00558  D-Tagaturonate
C00617  UDP-D-galacturonate
C00618  3-Dehydro-L-gulonate
C00652  D-Arabinono-1,4-lactone
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00878  D-Arabinonate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03033  beta-D-Glucuronoside
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03826  2-Dehydro-3-deoxy-D-xylonate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04037  1-Phospho-alpha-D-galacturonate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C06316  Dehydro-D-arabinono-1,4-lactone
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
C21955  L-Galactono-1,5-lactone
Reference
PMID:17222174
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
PMID:15564123
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
PMID:10517845
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
PMID:16595667
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
PMID:17462988
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
PMID:14996803
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
PMID:12644495
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003
Related
pathway
sspl00020  Citrate cycle (TCA cycle)
sspl00040  Pentose and glucuronate interconversions
sspl00051  Fructose and mannose metabolism
sspl00520  Amino sugar and nucleotide sugar metabolism
sspl00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00053   
LinkDB

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