Entry
Name
Ribosome biogenesis in eukaryotes - Triticum aestivum (bread wheat)
Description
Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage.
Class
Genetic Information Processing; Translation
BRITE hierarchy
Pathway map
Ortholog table
Organism
Triticum aestivum (bread wheat) [GN:
taes ]
Gene
543426 U3 small nucleolar ribonucleoprotein protein MPP10 [KO:K14559 ]
123120459 U3 small nucleolar ribonucleoprotein protein MPP10-like [KO:K14559 ]
123103083 U3 small nucleolar ribonucleoprotein protein MPP10-like [KO:K14559 ]
123046978 U3 small nucleolar ribonucleoprotein protein IMP3-like [KO:K14560 ]
123190652 U3 small nucleolar ribonucleoprotein protein IMP3-like [KO:K14560 ]
123054809 U3 small nucleolar ribonucleoprotein protein IMP3-like [KO:K14560 ]
123147344 U3 small nucleolar ribonucleoprotein protein IMP4-like [KO:K14561 ]
123166557 U3 small nucleolar ribonucleoprotein protein IMP4-like [KO:K14561 ]
123159149 U3 small nucleolar ribonucleoprotein protein IMP4-like [KO:K14561 ]
123093336 uncharacterized protein LOC123093336 isoform X1 [KO:K14563 ] [EC:2.1.1.-]
123129055 rRNA 2'-O-methyltransferase fibrillarin 1-like [KO:K14563 ] [EC:2.1.1.-]
123146227 rRNA 2'-O-methyltransferase fibrillarin 1-like [KO:K14563 ] [EC:2.1.1.-]
123165498 rRNA 2'-O-methyltransferase fibrillarin 1-like [KO:K14563 ] [EC:2.1.1.-]
123139921 rRNA 2'-O-methyltransferase fibrillarin 1-like [KO:K14563 ] [EC:2.1.1.-]
123159877 rRNA 2'-O-methyltransferase fibrillarin 1-like [KO:K14563 ] [EC:2.1.1.-]
123044066 H/ACA ribonucleoprotein complex subunit 4-like [KO:K11131 ] [EC:5.4.99.-]
123044067 H/ACA ribonucleoprotein complex subunit 4-like [KO:K11131 ] [EC:5.4.99.-]
123187822 H/ACA ribonucleoprotein complex subunit 4-like [KO:K11131 ] [EC:5.4.99.-]
123187823 H/ACA ribonucleoprotein complex subunit 4-like [KO:K11131 ] [EC:5.4.99.-]
123051941 H/ACA ribonucleoprotein complex subunit 4-like [KO:K11131 ] [EC:5.4.99.-]
123051942 H/ACA ribonucleoprotein complex subunit 4-like [KO:K11131 ] [EC:5.4.99.-]
123128270 H/ACA ribonucleoprotein complex subunit 2-like protein [KO:K11129 ]
123145367 H/ACA ribonucleoprotein complex subunit 2-like protein [KO:K11129 ]
123138118 H/ACA ribonucleoprotein complex subunit 2-like protein [KO:K11129 ]
123058638 putative H/ACA ribonucleoprotein complex subunit 1-like protein 1 [KO:K11128 ]
123079348 putative H/ACA ribonucleoprotein complex subunit 1-like protein 1 [KO:K11128 ]
123097243 putative H/ACA ribonucleoprotein complex subunit 1-like protein 1 [KO:K11128 ]
123065747 putative H/ACA ribonucleoprotein complex subunit 1-like protein 1 [KO:K11128 ]
123086038 putative H/ACA ribonucleoprotein complex subunit 1-like protein 1 [KO:K11128 ]
123091807 putative H/ACA ribonucleoprotein complex subunit 1-like protein 1 [KO:K11128 ]
123137490 H/ACA ribonucleoprotein complex subunit 3-like protein [KO:K11130 ]
123127759 H/ACA ribonucleoprotein complex subunit 3-like protein [KO:K11130 ]
123144844 H/ACA ribonucleoprotein complex subunit 3-like protein [KO:K11130 ]
123098409 RNA cytidine acetyltransferase 1-like isoform X1 [KO:K14521 ] [EC:2.3.1.-]
123110665 probable RNA 3'-terminal phosphate cyclase-like protein [KO:K11108 ]
123046165 probable RNA 3'-terminal phosphate cyclase-like protein [KO:K11108 ]
123117608 probable RNA 3'-terminal phosphate cyclase-like protein [KO:K11108 ]
123119669 probable RNA 3'-terminal phosphate cyclase-like protein [KO:K11108 ]
123102512 probable RNA 3'-terminal phosphate cyclase-like protein [KO:K11108 ]
123087779 probable RNA 3'-terminal phosphate cyclase-like protein isoform X1 [KO:K11108 ]
123110650 probable RNA 3'-terminal phosphate cyclase-like protein [KO:K11108 ]
123062223 small RNA degrading nuclease 5 isoform X1 [KO:K14570 ] [EC:3.1.-.-]
123079919 5'-3' exoribonuclease 3-like isoform X1 [KO:K12619 ] [EC:3.1.13.-]
Reference
Authors
Freed EF, Bleichert F, Dutca LM, Baserga SJ
Title
When ribosomes go bad: diseases of ribosome biogenesis.
Journal
Reference
Authors
Perez-Fernandez J, Roman A, De Las Rivas J, Bustelo XR, Dosil M
Title
The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism.
Journal
Reference
Authors
Strunk BS, Karbstein K
Title
Powering through ribosome assembly.
Journal
Reference
Authors
Granneman S, Baserga SJ
Title
Ribosome biogenesis: of knobs and RNA processing.
Journal
Reference
Authors
Kressler D, Hurt E, Bassler J
Title
Driving ribosome assembly.
Journal
Related pathway
KO pathway
LinkDB
All DBs