Entry
Name
ABC transporters - Ursus americanus (American black bear)
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Ursus americanus (American black bear) [GN:
uar ]
Gene
123781247 ABCA1; phospholipid-transporting ATPase ABCA1 isoform X1 [KO:K05641 ]
123796329 ABCA2; ATP-binding cassette sub-family A member 2 isoform X1 [KO:K05642 ]
123783732 LOW QUALITY PROTEIN: phospholipid-transporting ATPase ABCA3-like [KO:K05643 ]
123795197 ABCA4; LOW QUALITY PROTEIN: retinal-specific phospholipid-transporting ATPase ABCA4 [KO:K05644 ]
123794026 ABCA7; phospholipid-transporting ATPase ABCA7 isoform X1 [KO:K05645 ]
123802947 ABCA8; ABC-type organic anion transporter ABCA8 isoform X1 [KO:K05650 ]
123802981 ABCA9; ATP-binding cassette sub-family A member 9 isoform X1 [KO:K05651 ]
123803172 LOW QUALITY PROTEIN: ATP-binding cassette sub-family A member 10-like [KO:K05652 ]
123788780 ABCB8; mitochondrial potassium channel ATP-binding subunit isoform X1 [KO:K05655 ]
123782875 ABCB10; ATP-binding cassette sub-family B member 10, mitochondrial [KO:K05657 ]
123789586 ABCB5; LOW QUALITY PROTEIN: ATP-binding cassette sub-family B member 5 [KO:K05660 ]
123796203 ABCB7; iron-sulfur clusters transporter ABCB7, mitochondrial isoform X1 [KO:K05662 ]
123776813 ABCC3; ATP-binding cassette sub-family C member 3 isoform X1 [KO:K05667 ]
123801027 ABCC4; ATP-binding cassette sub-family C member 4 isoform X1 [KO:K05673 ]
123778950 ABCC5; ATP-binding cassette sub-family C member 5 isoform X1 [KO:K05668 ]
123778602 ABCC6; ATP-binding cassette sub-family C member 6 isoform X1 [KO:K05669 ]
123794752 ABCC10; LOW QUALITY PROTEIN: ATP-binding cassette sub-family C member 10 [KO:K05674 ]
123798381 ABCC11; ATP-binding cassette sub-family C member 11 isoform X1 [KO:K05671 ]
123791679 ABCC8; ATP-binding cassette sub-family C member 8 isoform X1 [KO:K05032 ]
123801628 ABCC9; ATP-binding cassette sub-family C member 9 isoform X1 [KO:K05033 ]
123777472 ABCG1; ATP-binding cassette sub-family G member 1 isoform X1 [KO:K05679 ]
123788319 ABCG2; broad substrate specificity ATP-binding cassette transporter ABCG2 isoform X1 [KO:K05681 ]
Compound
C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference
Authors
Tomii K, Kanehisa M.
Title
A comparative analysis of ABC transporters in complete microbial genomes.
Journal
Reference
Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal
Reference
Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal
Reference
Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal
Reference
Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal
Reference
Authors
Richard-Fogal CL, Frawley ER, Kranz RG
Title
Topology and function of CcmD in cytochrome c maturation.
Journal
Reference
Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal
Reference
Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal
Reference
Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal
Reference
Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal
KO pathway
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