KEGG   PATHWAY: vcrb04141
Entry
vcrb04141                   Pathway                                
Name
Protein processing in endoplasmic reticulum - Vespa crabro (European hornet)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
vcrb04141  Protein processing in endoplasmic reticulum
vcrb04141

Other DBs
GO: 0030433 0034976
Organism
Vespa crabro (European hornet) [GN:vcrb]
Gene
124430668  protein transport protein Sec61 subunit alpha [KO:K10956]
124423970  protein transport protein Sec61 subunit beta [KO:K09481]
124428681  protein transport protein Sec61 subunit gamma [KO:K07342]
124424642  translocation protein SEC62 [KO:K12275]
124429014  translocation protein SEC63 homolog [KO:K09540]
124425803  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [KO:K12666]
124423414  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667]
124430502  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
124424793  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
124428292  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
124431040  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B isoform X1 [KO:K07151] [EC:2.4.99.18]
124433082  tumor suppressor candidate 3 [KO:K19478]
124432900  oligosaccharyltransferase complex subunit ostc-B [KO:K26501]
124421730  transmembrane protein 258 [KO:K26502]
124422441  mannosyl-oligosaccharide glucosidase GCS1 [KO:K01228] [EC:3.2.1.106]
124428960  nucleotide exchange factor Sil1 [KO:K14001]
124422716  hypoxia up-regulated protein 1 isoform X1 [KO:K09486]
124428702  endoplasmic reticulum chaperone BiP isoform X1 [KO:K09490] [EC:3.6.4.10]
124422079  dnaJ homolog shv [KO:K09517]
124430750  dnaJ homolog subfamily C member 1-like [KO:K09521]
124424400  dnaJ homolog subfamily C member 3 [KO:K09523]
124430511  dnaJ homolog subfamily C member 10-like isoform X1 [KO:K09530] [EC:1.8.4.-]
124430725  endoplasmin [KO:K09487]
124428016  neutral alpha-glucosidase AB [KO:K05546] [EC:3.2.1.207]
124428017  neutral alpha-glucosidase AB-like [KO:K05546] [EC:3.2.1.207]
124432416  glucosidase 2 subunit beta [KO:K08288]
124427147  calnexin-like isoform X1 [KO:K08054]
124425941  protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
124427966  calreticulin [KO:K08057]
124424923  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA-like isoform X1 [KO:K01230] [EC:3.2.1.113]
124431711  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase [KO:K23741] [EC:3.2.1.209]
124428543  vesicular integral-membrane protein VIP36 [KO:K10082]
124427606  protein ERGIC-53 [KO:K10080]
124422462  prolactin regulatory element-binding protein [KO:K14003]
124429056  GTP-binding protein SAR1 [KO:K07953] [EC:3.6.5.-]
124424106  protein SEC13 homolog [KO:K14004]
124423349  protein transport protein Sec31A isoform X1 [KO:K14005]
124425989  protein transport protein Sec23A isoform X1 [KO:K14006]
124421869  protein transport protein Sec24A [KO:K14007]
124424509  protein transport protein Sec24C [KO:K14007]
124428749  UDP-glucose:glycoprotein glucosyltransferase isoform X1 [KO:K11718] [EC:2.4.1.-]
124430505  ER degradation-enhancing alpha-mannosidase-like protein 2 [KO:K10085]
124431879  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [KO:K10086]
124428956  protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
124426633  protein disulfide-isomerase A6 homolog [KO:K09584] [EC:5.3.4.1]
124427126  endoplasmic reticulum resident protein 29 [KO:K09586]
124424736  thioredoxin domain-containing protein 5 homolog [KO:K13984] [EC:5.3.4.1]
124431506  ero1-like protein [KO:K10950] [EC:1.8.4.-]
124426311  endoplasmic reticulum lectin 1 isoform X1 [KO:K14008]
124432764  translocon-associated protein subunit alpha isoform X1 [KO:K13249]
124425264  translocon-associated protein subunit beta [KO:K13250]
124425517  translocon-associated protein subunit gamma [KO:K13251]
124426829  translocon-associated protein subunit delta [KO:K04571]
124421526  B-cell receptor-associated protein 31 [KO:K14009]
124424753  translocating chain-associated membrane protein 1 isoform X1 [KO:K14010]
124432765  derlin-1 [KO:K11519]
124427267  derlin-2 isoform X1 [KO:K13989]
124428254  UBX domain-containing protein 1 [KO:K24348]
124428336  UBX domain-containing protein 4-like [KO:K24348]
124424705  UBX domain-containing protein 6 [KO:K14011]
124432128  NSFL1 cofactor p47 [KO:K14012]
124427341  small VCP/p97-interacting protein [KO:K14014]
124432940  transitional endoplasmic reticulum ATPase TER94 [KO:K13525]
124429489  nuclear protein localization protein 4 homolog isoform X1 [KO:K14015]
124432178  ubiquitin fusion degradation protein 1 homolog isoform X1 [KO:K14016]
124425724  heat shock 70 kDa protein cognate 4-like [KO:K03283]
124423907  heat shock protein 68-like [KO:K03283]
124425053  heat shock 70 kDa protein cognate 4 [KO:K03283]
124432254  dnaJ homolog subfamily A member 1 [KO:K09502]
124432208  dnaJ protein homolog 1 [KO:K09507]
124424358  dnaJ homolog subfamily B member 12 [KO:K09518]
124428871  dnaJ homolog subfamily C member 5-like isoform X1 [KO:K09525]
124428069  heat shock protein 83 [KO:K04079]
124430589  heat shock protein 83-like [KO:K04079]
124429271  97 kDa heat shock protein isoform X1 [KO:K09485]
124424622  BAG family molecular chaperone regulator 2 isoform X1 [KO:K09556]
124421942  hsp70-binding protein 1-like [KO:K09562]
124425607  protein lethal(2)essential for life-like [KO:K09542]
124429862  protein lethal(2)essential for life-like [KO:K09542]
124430572  protein lethal(2)essential for life-like [KO:K09542]
124430794  protein lethal(2)essential for life-like [KO:K09542]
124430795  protein lethal(2)essential for life-like [KO:K09542]
124430796  protein lethal(2)essential for life-like [KO:K09542]
124431707  protein lethal(2)essential for life-like isoform X1 [KO:K09542]
124430011  ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
124430768  phospholipase A-2-activating protein [KO:K14018]
124430219  UV excision repair protein RAD23 homolog A [KO:K10839]
124432184  ubiquilin-1 [KO:K04523]
124430583  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase [KO:K01456] [EC:3.5.1.52]
124430595  ataxin-3-like isoform X1 [KO:K11863] [EC:3.4.22.-]
124426705  ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
124429807  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
124423056  activating transcription factor of chaperone isoform X1 [KO:K04374]
124429481  cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
124428539  wolframin isoform X1 [KO:K14020]
124431210  membrane-bound transcription factor site-1 protease isoform X1 [KO:K08653] [EC:3.4.21.112]
124422003  membrane-bound transcription factor site-2 protease isoform X1 [KO:K07765] [EC:3.4.24.85]
124423231  X-box-binding protein 1 [KO:K09027]
124424821  serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
124432768  mitogen-activated protein kinase kinase kinase 15 isoform X1 [KO:K04426] [EC:2.7.11.25]
124423335  dual specificity mitogen-activated protein kinase kinase 7-like isoform X1 [KO:K04431] [EC:2.7.12.2]
124429643  stress-activated protein kinase JNK isoform X1 [KO:K04440] [EC:2.7.11.24]
124424873  E3 ubiquitin-protein ligase MARCHF6 isoform X1 [KO:K10661] [EC:2.3.2.27]
124426366  ubiquitin-conjugating enzyme E2 J1-like [KO:K10578] [EC:2.3.2.23]
124428341  ubiquitin-conjugating enzyme E2 J2 isoform X1 [KO:K04554] [EC:2.3.2.23]
124429771  ubiquitin-conjugating enzyme E2 G1 isoform X1 [KO:K10575] [EC:2.3.2.23]
124433008  ubiquitin-conjugating enzyme E2 G2 isoform X1 [KO:K04555] [EC:2.3.2.23]
124424145  E3 ubiquitin-protein ligase synoviolin A isoform X1 [KO:K10601] [EC:2.3.2.27]
124429350  E3 ubiquitin-protein ligase RNF185-like [KO:K10666] [EC:2.3.2.27]
124423735  uncharacterized protein LOC124423735 [KO:K14025]
124425797  protein sel-1 homolog 1 [KO:K14026]
124430500  E3 ubiquitin-protein ligase AMFR-like [KO:K10636] [EC:2.3.2.36]
124423039  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
124427076  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
124432748  E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
124431779  RING-box protein 1A isoform X1 [KO:K03868] [EC:2.3.2.32]
124427639  cullin-1 isoform X1 [KO:K03347]
124432509  S-phase kinase-associated protein 1 [KO:K03094]
124431334  F-box only protein 44-like [KO:K10100]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
vcrb00510  N-Glycan biosynthesis
vcrb03050  Proteasome
vcrb03060  Protein export
KO pathway
ko04141   
LinkDB

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