KEGG   PATHWAY: vlg03013
Entry
vlg03013                    Pathway                                
Name
Nucleocytoplasmic transport - Vulpes lagopus (Arctic fox)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
vlg03013  Nucleocytoplasmic transport
vlg03013

Other DBs
GO: 0050658
Organism
Vulpes lagopus (Arctic fox) [GN:vlg]
Gene
121471401  [KO:K12160]
121471812  NUP35; nucleoporin NUP35 [KO:K14313]
121471928  [KO:K14303]
121472097  [KO:K12877]
121472586  [KO:K10577]
121472589  KPNA2; importin subunit alpha-1 [KO:K15043]
121473062  NUP214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
121473298  TMEM33; transmembrane protein 33 isoform X1 [KO:K20724]
121473408  KPNB1; importin subunit beta-1 [KO:K14293]
121473422  NUP188; nucleoporin NUP188 isoform X1 [KO:K14311]
121473667  CASC3; protein CASC3 [KO:K14323]
121473929  NUP85; nuclear pore complex protein Nup85 [KO:K14304]
121473938  SUMO2; small ubiquitin-related modifier 2 [KO:K12160]
121474034  ALYREF; THO complex subunit 4 [KO:K12881]
121474121  [KO:K18723]
121474161  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
121474495  XPO5; exportin-5 isoform X1 [KO:K14289]
121474692  TNPO3; transportin-3 isoform X1 [KO:K15436]
121474835  NUP42; nucleoporin NUP42 isoform X1 [KO:K14321]
121475381  THOC5; THO complex subunit 5 homolog isoform X1 [KO:K13174]
121475819  RAN; GTP-binding nuclear protein Ran [KO:K07936]
121476050  IPO7; importin-7 isoform X1 [KO:K20223]
121476255  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
121476631  NUP43; nucleoporin Nup43 [KO:K14305]
121476799  [KO:K12160]
121476865  UPF3A; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
121476981  KPNA3; importin subunit alpha-4 [KO:K23583]
121476996  IPO5; importin-5 [KO:K20222]
121477308  KPNA4; importin subunit alpha-3 isoform X1 [KO:K23583]
121477416  NMD3; 60S ribosomal export protein NMD3 isoform X1 [KO:K07562]
121477508  SENP2; sentrin-specific protease 2 isoform X1 [KO:K03345] [EC:3.4.22.68]
121478110  CSE1L; exportin-2 isoform X1 [KO:K18423]
121478296  EEF1A2; elongation factor 1-alpha 2 [KO:K03231]
121478354  RAE1; mRNA export factor [KO:K14298]
121478450  NXT1; NTF2-related export protein 1 [KO:K14285]
121478851  [KO:K15043]
121479074  [KO:K14324]
121479402  SUMO3; small ubiquitin-related modifier 3 [KO:K12160]
121479842  [KO:K12160]
121479897  IPO8; importin-8 isoform X1 [KO:K18755]
121480109  AAAS; aladin isoform X1 [KO:K14320]
121480265  MAGOHB; protein mago nashi homolog 2 [KO:K12877]
121480678  SUMO1; small ubiquitin-related modifier 1 [KO:K12160]
121481076  [KO:K13176]
121481273  IPO13; importin-13 [KO:K25202]
121481340  [KO:K12877]
121481580  NUP37; nucleoporin Nup37 [KO:K14302]
121481877  [KO:K14284]
121482460  [KO:K12160]
121482609  NCBP2L; nuclear cap-binding protein subunit 2-like [KO:K12883]
121482676  [KO:K14284]
121482691  [KO:K03231]
121482747  [KO:K12160]
121482808  THOC2; THO complex subunit 2 isoform X1 [KO:K12879]
121482818  UPF3B; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
121482982  [KO:K03231]
121483192  [KO:K03231]
121483223  NUP62CL; nucleoporin-62 C-terminal-like protein isoform X1 [KO:K14306]
121483409  [KO:K14284]
121483425  [KO:K14284]
121483609  NXT2; NTF2-related export protein 2 [KO:K14285]
121484203  [KO:K07936]
121484371  NUP62; nuclear pore glycoprotein p62 [KO:K14306]
121484664  [KO:K13175]
121484728  NUP210L; nuclear pore membrane glycoprotein 210-like isoform X1 [KO:K14314]
121485100  KPNA5; importin subunit alpha-6 [KO:K15042]
121485768  SNUPN; snurportin-1 isoform X1 [KO:K13151]
121486134  THOC3; THO complex subunit 3 [KO:K12880]
121486629  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
121486837  XPO6; exportin-6 isoform X1 [KO:K25204]
121487318  POM121C; nuclear envelope pore membrane protein POM 121C [KO:K14316]
121487610  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
121487656  KPNA7; importin subunit alpha-8 isoform X1 [KO:K15043]
121487908  RANBP17; ran-binding protein 17 isoform X1 [KO:K24115]
121487974  NUP133; nuclear pore complex protein Nup133 [KO:K14300]
121488065  NUP155; nuclear pore complex protein Nup155 [KO:K14312]
121488089  THOC6; THO complex subunit 6 homolog [KO:K13175]
121488174  AHCTF1; protein ELYS isoform X1 [KO:K25129]
121488786  [KO:K20223]
121488813  [KO:K03231]
121488928  THOC1; THO complex subunit 1 [KO:K12878]
121488939  [KO:K15043]
121489390  [KO:K13171]
121489495  [KO:K12160]
121489826  [KO:K12160]
121490178  NUP205; nuclear pore complex protein Nup205 [KO:K14310]
121490610  [KO:K03231]
121490751  RANBP2; E3 SUMO-protein ligase RanBP2 isoform X1 [KO:K12172] [EC:2.3.2.-]
121490795  TPR; nucleoprotein TPR isoform X1 [KO:K09291]
121490821  KPNA1; importin subunit alpha-5 [KO:K23940]
121490950  XPO1; exportin-1 [KO:K14290]
121491112  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
121491303  NUP50; nuclear pore complex protein Nup50 [KO:K14295]
121491640  RANGAP1; ran GTPase-activating protein 1 [KO:K14319]
121491932  XPOT; exportin-T isoform X1 [KO:K14288]
121491959  [KO:K15043]
121492105  PYM1; partner of Y14 and mago [KO:K14294]
121492170  NUP107; nuclear pore complex protein Nup107 isoform X1 [KO:K14301]
121492476  [KO:K15043]
121492692  [KO:K03231]
121492722  [KO:K12160]
121492894  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
121492983  IPO4; importin-4 isoform X1 [KO:K20221]
121493279  IPO9; importin-9 [KO:K20224]
121493606  PNN; pinin [KO:K13114]
121493632  NUP54; nucleoporin p54 isoform X1 [KO:K14308]
121493788  [KO:K12160]
121493857  [KO:K03231]
121494455  UPF1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
121494727  NUP210; nuclear pore membrane glycoprotein 210 isoform X1 [KO:K14314]
121495108  DDX39B; spliceosome RNA helicase DDX39B isoform X1 [KO:K12812] [EC:5.6.2.7]
121495217  [KO:K03231]
121495386  TNPO2; transportin-2 isoform X1 [KO:K18727]
121495460  NCBP1; nuclear cap-binding protein subunit 1 [KO:K12882]
121495489  SEC13; protein SEC13 homolog [KO:K14004]
121495888  THOC7; THO complex subunit 7 homolog isoform X1 [KO:K13176]
121496024  PHAX; phosphorylated adapter RNA export protein isoform X1 [KO:K14291]
121496271  [KO:K03231]
121496338  SEH1L; nucleoporin SEH1 isoform X1 [KO:K14299]
121496745  XPO7; exportin-7 isoform X1 [KO:K18460]
121496928  TNPO1; transportin-1 isoform X1 [KO:K18752]
121497098  SRRM1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
121497242  UPF2; regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
121497298  KPNA6; importin subunit alpha-7 [KO:K15042]
121497349  NUP58; nucleoporin p58/p45 isoform X1 [KO:K14307]
121497372  IPO11; importin-11 [KO:K25201]
121497483  [KO:K03231]
121497572  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
121497624  NUP93; nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
121497834  [KO:K13171]
121498218  XPO4; exportin-4 isoform X1 [KO:K25203]
121498606  NCBP2; nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883]
121499530  MAGOH; protein mago nashi homolog [KO:K12877]
121499883  POM121L2; LOW QUALITY PROTEIN: POM121-like protein 2 [KO:K14316]
121499978  NUP153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
121500134  DDX19B; ATP-dependent RNA helicase DDX19B isoform X1 [KO:K18655] [EC:5.6.2.7]
121500209  [KO:K03231]
121500429  NUP88; nuclear pore complex protein Nup88 isoform X1 [KO:K14318]
121500497  NDC1; nucleoporin NDC1 [KO:K14315]
121500524  [KO:K18655] [EC:5.6.2.7]
121500632  [KO:K15043]
121501530  NXF1; nuclear RNA export factor 1 [KO:K14284]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
vlg03015  mRNA surveillance pathway
KO pathway
ko03013   

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