Entry
Name
Glycine, serine and threonine metabolism - Xenorhabdus bovienii SS-2004
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:
M00020 ], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:
M00018 ].
Class
Metabolism; Amino acid metabolism
BRITE hierarchy
Pathway map
xbo00260 Glycine, serine and threonine metabolism
Ortholog table
Module
Other DBs
Organism
Xenorhabdus bovienii SS-2004 [GN:
xbo ]
Gene
XBJ1_3515 thrA; bifunctional: aspartokinase I (N-terminal); homoserine dehydrogenase I (C-terminal), threonine sensitive [KO:K12524 ] [EC:2.7.2.4 1.1.1.3 ]
XBJ1_4276 metL; bifunctional: aspartokinase II (N-terminal); homoserine dehydrogenase II (C-terminal), methionine sensitive [KO:K12525 ] [EC:2.7.2.4 1.1.1.3 ]
XBJ1_3434 gcvP; glycine cleavage complex protein P, glycine decarboxylase, PLP-dependent [KO:K00281 ] [EC:1.4.4.2 ]
XBJ1_3436 gcvT; glycine cleavage complex protein T, aminomethyltransferase, tetrahydrofolate-dependent [KO:K00605 ] [EC:2.1.2.10 ]
XBJ1_3453 lpd; dihydrolipoamide dehydrogenase, FAD/NAD(P)-binding, component of the 2-oxoglutarate dehydrogenase and the pyruvate dehydrogenase complexes [KO:K00382 ] [EC:1.8.1.4 ]
XBJ1_3435 gcvH; glycine cleavage complex protein H, carrier of aminomethyl moiety via covalently bound lipoyl cofactor [KO:K02437 ]
XBJ1_3251 pssA; phosphatidylserine synthase (CDP-diacylglycerol-serine O-phosphatidyltransferase) [KO:K00998 ] [EC:2.7.8.8 ]
Compound
C00143 5,10-Methylenetetrahydrofolate
C00441 L-Aspartate 4-semialdehyde
C01242 [Protein]-S8-aminomethyldihydrolipoyllysine
C03508 L-2-Amino-3-oxobutanoic acid
C06442 N(gamma)-Acetyldiaminobutyrate
C19929 N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
Title
[Cellular Functions and Metabolic Maps] (In Japanese)
Journal
Tokyo Kagaku Dojin (1997)
Reference
Authors
Kuhlmann AU, Bremer E.
Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
Journal
Reference
Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
Journal
Reference
Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
Journal
Reference
Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
Journal
Reference
Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
Journal
Reference
Authors
Rees WD, Hay SM
Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
Journal
Reference
Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
Journal
Reference
Authors
Chen X, Jhee KH, Kruger WD
Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
Journal
Related pathway
xbo00250 Alanine, aspartate and glutamate metabolism
xbo00270 Cysteine and methionine metabolism
xbo00290 Valine, leucine and isoleucine biosynthesis
xbo00330 Arginine and proline metabolism
xbo00630 Glyoxylate and dicarboxylate metabolism
KO pathway
LinkDB
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